Vascular Structure and Function in Aged Skeletal Muscle

老年骨骼肌的血管结构和功能

基本信息

批准号：
7232095
负责人：
Brad J Behnke
金额：
$ 4.88万
依托单位：
WEST VIRGINIA UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-04-01 至 2009-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7232095
关键词：
Acetylcholine Acute Address Adrenergic Receptor Age Age-Months Aging Animals Arteries Arts Attenuated Blood Vessels Blood capillaries Blood flow Bradykinin Caliber Condition Contracts Data Development Elderly Electromyography Endothelium Erythrocytes Exercise Exercise Tolerance Fellowship Functional disorder Gastrocnemius Muscle Growth Factor Heart Heart Rate Hindlimb Human Individual Invasive Link Location Measurement Measures Mediating Messenger RNA Metabolic Microcirculation Microspheres Modeling Molecular Muscle Muscle function Names Numbers Oxygen Pattern Physical Capacity Physical activity Population Prostaglandin-Endoperoxide Synthase Prostaglandins Proteins Protocols documentation Pulmonary Gas Exchange Radioactive Range Rate Rattus Receptors, Adrenergic, alpha-2 Relative (related person)Relaxation Resistance Resolution Rest Rodent Skeletal Muscle Smooth Muscle Soleus Muscle Structure Techniques Testing Thinking Time Vascular Endothelial Growth Factor Receptor Vascular Endothelial Growth Factors Vascular remodeling Vasodilation Work age effect age group age related aged alpha-adrenergic receptor analog arteriole base capillary cyclooxygenase 1 day density design desire feeding impaired driving performance mRNA Expression middle age oxygen transport protein expression receptor receptor density response shear stress uptake

项目摘要

DESCRIPTION (provided by applicant): Physical capacity and muscular function are reduced with aging. Age-associated reduction in muscle blood flow and its intravascular distribution within and between skeletal muscles is thought to be linked mechanistically to muscle dysfunction in older individuals. This is supported by the observation that pulmonary gas exchange dynamics are slowed with advancing age and it is now recognized that these changes are driven by impaired muscle oxygen exchange and result in elevated metabolic perturbations within contracting muscle that limit exercise tolerance. To date, however, key structural and functional relationships within young and aged skeletal muscle remain obscure. Dr. Delp's lab has assembled a unique combination of established and state-of-the art techniques to address this problem. I plan to test the broad hypothesis that aging induces microcirculatory dysfunction that impairs oxygen transport. This work will utilize the rat model of aging, a widely accepted analog of the human condition that has the major advantage of permitting very invasive studies. Development of effective strategies to attenuate the deleterious effects of aging on physical capacity is contingent upon resolution of the mechanistic bases for muscle dysfunction in this population.

描述（由申请人提供）：身体能力和肌肉功能随着年龄的增长而下降。与年龄相关的肌肉血流量及其在骨骼肌内和之间的血管内分布的减少被认为在机制上与老年人的肌肉功能障碍有关。观察结果支持了这一点，即肺部气体交换动力学随着年龄的增长而减慢，现在人们认识到这些变化是由肌肉氧交换受损驱动的，并导致收缩肌肉内的代谢扰动升高，从而限制了运动耐量。然而，迄今为止，年轻和老年骨骼肌内的关键结构和功能关系仍然不清楚。德尔普博士的实验室将现有的最先进技术进行了独特的组合来解决这个问题。我计划检验一个广泛的假设，即衰老会导致微循环功能障碍，从而损害氧气输送。这项工作将利用大鼠衰老模型，这是一种广泛接受的人类状况模拟模型，其主要优点是允许进行非常侵入性的研究。制定有效策略来减轻衰老对身体能力的有害影响取决于解决该人群肌肉功能障碍的机制基础。