New York Columbia Collaborative SPOTRIAS

纽约哥伦比亚合作 SPOTRIAS

• 批准号: 7259368
• 负责人: Randolph S Marshall
• 金额: $ 203.34万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-30 至 2009-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7259368
• 关键词: New; York; Columbia; Collaborative; SPOTRIAS

The New York Columbia Collaborative Specialized Program on Translational Research In Acute Stroke will involve key personnel from Columbia University and the NY Presbyterian Hospital. The overall goals are to enhance the delivery of acute stroke patient care with a focus on a high-risk disadvantaged population, train acute stroke translational researchers, and conduct 3 innovative acute stroke projects. The projects share subjects identified through the patient access core, and utilize blood and data management and statistics cores. Project 1 is a dose-escalation and pilot clinical trial to evaluate the effects of short-term early use of high-dose simvastatin therapy (Neu-START: Neuroprotection with Statin Therapy for Acute Recovery Trial). Simvastatin has been shown in rodent stroke models to reduce neuronal injury and infarct size primarily related to improving vascular flow and function rather than on a direct neuronal cytoprotective benefit. This translational project will randomize 60 acute strokes within 12 hours for phase IB and 90 within 6 hours for phase IIA and evaluate safety and surrogate measures of systemic inflammatory markers. Project 2 (Brain Plasticity in Acute Stroke: a Functional MRI Study) will investigate the unexplained variability in early stroke outcomes by evaluating the role of brain plasticity in the acute time period. To determine the network of contralesional brain regions after acute stroke that predicts good stroke recovery at 1 week and 3 months, we will recruit 100 acute stroke patients, and obtain fMRI scans at 24 to 48 hours. Project 3 (SWIFT: Stroke Warning Information and Faster Treatment) will be aimed at decreasing the delay in presentation of acute stroke patients to the hospital from a disadvantaged population. To evaluate the efficacy of a culturally sensitive, targeted educational/behavioral modification program performed over three interactive sessions, we will randomize 1400 strokeATIA survivors and 1200 community subjects and assess changes in stroke knowledge and behavior, as well as improvement in time to arrival to the ED.

纽约哥伦比亚急性中风转化研究专业计划将涉及哥伦比亚大学和纽约长老会医院的关键人员。总体目标是增强急性中风患者护理的交付，重点关注高危人群，火车急性中风翻译研究人员，并进行3个创新的急性中风项目。这些项目共享通过患者访问核心确定的主题，并利用血液，数据管理和统计核心。项目1是一项剂量降低和试验临床试验，可评估高剂量辛伐他汀治疗的短期早期使用的影响（NEU-Start：毒他汀类药物治疗的神经保护症进行急性恢复试验）。 辛伐他汀已在啮齿动物中风模型中显示，以减少神经元损伤和梗塞大小，主要与改善血管流量和功能相关，而不是直接神经元细胞保护益处。该翻译项目将在IA期内12小时内在12小时内在12小时内随机进行60次急性中风，并在6小时内进行90个急性中风，并评估系统性炎症标记的安全性和替代测量。项目2（急性中风中的大脑可塑性：一项功能性MRI研究）将通过评估急性时期脑可塑性的作用来研究早期中风结果中无法解释的变异性。为了确定急性中风后对侧大脑区域的网络，该网络可以预测1周零3个月的良好中风恢复 我们将招募100名急性中风患者，并在24至48小时以24至48小时的速度进行fMRI扫描。项目3（Swift：中风警告信息和更快的治疗速度）将旨在减少急性中风患者向医院的延迟延迟到处境不利的人群中。为了评估在三个互动会议上执行的具有文化敏感的，有针对性的教育/行为修改计划的疗效，我们将随机分配1400名Strokeatia幸存者和1200个社区受试者，并评估中风知识和行为的变化，以及时间改善到达ED。