Quality of life among breast cancer survivors

乳腺癌幸存者的生活质量

• 批准号: 7525196
• 负责人: Grace Yoo
• 金额: $ 20.46万
• 依托单位: SAN FRANCISCO STATE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7525196
• 关键词: African American; Asian Americans; Hispanic Americans; behavioral /social science research tag; breast neoplasms; caucasian American; clinical research; culture; depression; female; health disparity; health science research support; human subject; neoplasm /cancer remission /regression; quality of life; racial /ethnic difference; religion; social support network; women' s health

We propose to study the trajectory of quality of life for a two-year period in four distinct subgroups of breast cancer survivors: African-American, Asian-American, Latina, and white American women. The primary goal of our project is to study how being a breast cancer survivor affects the trajectory of quality of life in different race/ethnic groups, and how that relationship is modified by social support, depression, and spirituality. We aim to 1) to adjust and supplement existing measures of quality of life, social support, depression, and spirituality for breast cancer survivors in relation to racial/ethnic and cultural variation, 2) to study quantitatively trajectories of quality of life, social support, depression, and spirituality for two years using cross-culturally comparable quantitative measures and 3) to determine the degree to which social support, spirituality and depression explain and interpret the relationship between race/ethnicity and the trajectory of quality of life among breast cancer survivors, independently of differences in clinical prognosis at the end of treatment and/or stage of disease at diagnosis. These aims will be pursued in two samples of breast cancer survivors: 20 survivors, five from each race/ethnic group, who will participate in three depth interviews over the course of one year to provide the qualitative data to revise standard measures of quality of life, social support, spirituality, and depression to make them more suitable for comparisons between race and ethnic groups; 135 survivors in roughly equal numbers from each race/ethnic group who will be given a brief interview at intake and in four follow-up contacts over two years to provide culturally-comparable quantitative longitudinal data to test hypotheses about race/ethnic differentials in trajectories of quality of life and its determinants.

我们建议在四个不同的乳腺癌幸存者中研究两年的生活质量轨迹：非裔美国人，亚裔美国人，拉丁裔和美国白人妇女。我们项目的主要目标是研究乳腺癌幸存者如何影响不同种族/族裔群体生活质量的轨迹，以及如何通过社会支持，抑郁和灵性来改变这种关系。我们的目标是1）调整和补充现有的与种族/种族和文化变化有关的乳腺癌幸存者的生活质量，社会支持，抑郁和灵性的度量，2） 使用跨文化可比的定量措施和3）确定社会支持，精神和抑郁解释和解释乳腺癌幸存者生活质量的轨迹，在治疗和阶段诊断临床预测中的差异，在乳腺癌幸存者之间的差异和/或或诊断阶段的差异。这些目标将在两个乳腺癌幸存者样本中追求：20个幸存者，每个种族/族裔群体中有5个，他们将在一年的时间内参加三次深度访谈，以提供定性数据，以修改生活质量，社会支持，精神性，抑郁症的标准度量，使他们更适合于种族之间的比较。 和种族群体；与每个种族/族裔群体相比，135个幸存者将在摄入量中进行简短的访谈，并在两年内进行四次随访接触，以提供具有文化可靠的定量纵向数据，以测试有关种族/族裔差异的假设，以实现生活质量质量及其决定性的轨迹。