Novel Therapy to Treat Otitis Media

治疗中耳炎的新疗法

基本信息

批准号：
7482156
负责人：
Charles J Gauntt
金额：
$ 10.7万
依托单位：
BIOMEDICAL DEVELOPMENT CORPORATION
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-06-01 至 2010-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7482156
关键词：
2-cyclopentyl-5-(5-isoquinolylsulfonyl)-6-nitro-1H-benzo(D)imidazole Acute Age Animal Model Anti-Bacterial Agents Antibiotic Resistance Antibiotic Therapy Antibiotics Aspirate substance Bacteria Candida Childhood Chinchilla (genus)Chronic Clinical Collaborations Complex DNA Development Diagnosis Direct Costs Disease Disease remission Doctor of Philosophy Drug Formulations Effectiveness End Point Endotoxins Engineering Environment Evaluation Eye Fever Genome Goals Government Gram-Negative Bacteria Haemophilus influenzae Hour Immunology In Vitro Infection Inflammatory Iodine Lead Liquid substance Methods Microbial Biofilms Microbiology Modeling Molecular Moraxella (Branhamella) catarrhalis Mucous Membrane Nontypable Haemophilus influenza North Carolina Operative Surgical Procedures Oral mucous membrane structure Otitis Media Otitis Media with Effusion Pain Patients Penetration Persons Pharmacologic Substance Phase I Clinical Trials Play Principal Investigator Process Protocols documentation Public Health Purpose RNA Range Rate Rattus Research Personnel Resistance Resistance development Role Safety Scientist Skin Solutions Streptococcus pneumoniae Symptoms Technology Testing Toxic effect Treatment Efficacy Tympanic membrane Universities Virus Visit antimicrobial aqueous base chemical reaction cytotoxic design drug development experience forest hyperthermia treatment improved in vivo innovation medical schools microbial microbial community middle ear novel pathogen prescription document prescription procedure professor prototype treatment effect

项目摘要

DESCRIPTION (provided by applicant): Otitis media is a common childhood disease with annual direct costs estimated to exceed $3 billion. Otitis media is the most frequent cause of pediatric practitioner visits and results in more than 20 million antibiotic prescriptions annually. However, the pathogens associated with otitis media have become increasingly resistant to the prescribed antibiotics. Molecular examination of chronic cases of otitis media demonstrates the presence of bacteria encased in complex microbial communities known as biofilms. Antibiotic agents have proven to be ineffective against biofilm infections seen in chronic otitis media. A therapy that is effective against both chronic and acute otitis media, that does not induce microbial resistance, and that is effective against biofilms would be highly beneficial and have significant commercial potential. The goal of this project is to develop a unique, safe, and efficacious treatment for both acute and chronic otitis media. Prototype formulations will be tested in vitro and in an animal model of otitis media. The Specific Aims of the proposal are: Specific Aim 1. Formulate Iocide for use in treating otitis media Specific Aim 2. Evaluate Iocide for antibacterial activity on planktonic and biofilm bacteria in vitro Specific Aim 3. Demonstrate the effectiveness and safety of Iocide in an animal model of otitis media. PUBLIC HEALTH RELEVANCE: Otitis media is a common childhood disease with annual direct costs estimated to exceed $3 billion. Otitis media is the most frequent cause of pediatric practitioner visits and results in more than 20 million antibiotic prescriptions annually. Consequent to the widespread use of antibiotics, the pathogens associated otitis media have become increasingly resistant to antibiotic therapy.

描述（由申请人提供）：中耳炎是一种常见的儿童疾病，每年的直接费用估计超过 30 亿美元。中耳炎是儿科医生就诊的最常见原因，每年导致超过 2000 万张抗生素处方。然而，与中耳炎相关的病原体对处方抗生素的耐药性越来越强。对慢性中耳炎病例的分子检查表明，复杂的微生物群落（称为生物膜）中存在细菌。抗生素已被证明对慢性中耳炎中的生物膜感染无效。一种对慢性和急性中耳炎都有效、不诱导微生物耐药性、并且对生物膜有效的疗法将是非常有益的并且具有巨大的商业潜力。该项目的目标是开发一种独特、安全、有效的治疗急性和慢性中耳炎的方法。原型制剂将在体外和中耳炎动物模型中进行测试。该提案的具体目标是：具体目标 1. 配制 Iocide 用于治疗中耳炎具体目标 2. 评估 Iocide 对体外浮游细菌和生物膜细菌的抗菌活性具体目标 3. 证明 Iocide 在动物中的有效性和安全性中耳炎模型。公共卫生相关性：中耳炎是一种常见的儿童疾病，每年的直接费用估计超过 30 亿美元。中耳炎是儿科医生就诊的最常见原因，每年导致超过 2000 万张抗生素处方。由于抗生素的广泛使用，与中耳炎相关的病原体对抗生素治疗的耐药性越来越强。