Systems Biology Platform to Study the Influence of Nutrient Compounds on Cancer D

研究营养化合物对癌症 D 影响的系统生物学平台

基本信息

批准号：
7538045
负责人：
Yuri V. Nikolsky
金额：
$ 14.05万
依托单位：
GENEGO, INC.
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-01 至 2009-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7538045
关键词：
Academia Address Age of Onset Biological Biological Markers Blood Cancer Patient Cancer and Nutrition Categories Clinical Data Collaborations Collection Complex Mixtures Computer software Computers Computing Methodologies Data Data Analyses Data Set Data Sources Databases Descriptor Development Diagnostic Neoplasm Staging Diet Dietary Component Dietary Intervention Dimensions Disease Disease Progression Disease model Drug Receptors Foundations Gene Expression Gene Proteins Generations Genes Genetic Polymorphism Genetic Transcription Genome Health Hereditary Disease Human Imagery Industry Java Knowledge Leukocytes Link Malignant Neoplasms Marketing Metabolic Metabolic Pathway Molecular Monitor Nutrient Onset of illness Organ Outcome Pathway interactions Pharmacologic Substance Phase Phenotype Population Prevention Prostate-Specific Antigen Proteins Proteomics Public Health Published Database Publishing RNA Research Research Personnel Resources Risk Factors Running Sampling Science Signal Transduction Software Tools Statistically Significant System Systems Analysis Systems Biology Technology Tissues Today Transcript Variant Work base cancer prevention design disorder prevention gene interaction genetic association interest knowledge base metabolomics novel nutrition prevent programs protein protein interaction research study tool transcriptomics translational medicine

项目摘要

DESCRIPTION (provided by applicant): Early dietary intervention for preventing disease onset or progression requires an understanding of the molecular mechanisms of nutrient-gene interactions contributing to disease. To date, no database or set of analysis tools exists that sufficiently addresses these needs. We propose to develop a database and analysis platform specifically designed for investigating the influence of nutrients on the development and progression of human cancers, comprising i) a comprehensive database of nutrient-protein, nutrient-gene (and polymorphism) interactions, and indirect associations between nutrient compounds and cancer phenotypes such as age of onset, stage of cancer, and association with cancer biomarkers; ii) a comprehensive collection of nutrigenomics datasets (gene-expression, proteomics, metabolomics) and human white blood cell (lymphochip) gene expression experiments; iii) a set of software tools that will enable the analysis of systems biology datasets (including the ability to address different data types together) to construct nutrient-centered metabolic and signaling networks, pathways, and disease models, and to identify potential strategies and targets for nutritional intervention to reduce risk factors and augment treatment. The product will be unique in the marketplace and of great interest to academic researchers, foundations and pharmaceutical companies performing research into the association between diet and disease development. PUBLIC HEALTH RELEVANCE: This proposal aims to develop a knowledge-base and suite of data analysis tools specifically designed to facilitate the design and interpretation of nutrigenomic and nutrigenetic experiments investigating the link between dietary components and human cancer development.

描述（由申请人提供）：预防疾病发作或进展的早期饮食干预需要了解导致疾病的营养基因相互作用的分子机制。迄今为止，没有足够满足这些需求的数据库或一组分析工具。我们建议开发一个专门设计的数据库和分析平台，该数据库和分析平台旨在研究养分对人类癌症的发展和进展的影响，包括i）全面的养分 - 养分 - 养分 - 基因（和多态性）相互作用的数据库，以及养分和癌症现象与癌症现象之间的癌症和癌症的癌症，癌症和癌症的癌症和癌症的癌症，并与癌症之间的癌症，以及癌症的癌症，疾病，阶段，疾病和癌症之间的关联; ii）全面收集了营养学数据集（基因表达，蛋白质组学，代谢组学）和人类白细胞（淋巴机）基因表达实验的收集； iii）一组软件工具，将使系统生物学数据集分析（包括解决不同数据类型的能力），以构建以营养为中心的代谢网络和信号网络，途径和疾病模型，并确定营养干预的潜在策略和目标，以减少风险因素并增强风险因素。该产品将在市场上是独一无二的，并且对学术研究人员，基金会和制药公司非常感兴趣，该公司对饮食与疾病发展之间的关联进行研究。公共卫生相关性：该提案旨在开发一个知识库和一套数据分析工具，专门设计，旨在促进研究和解释营养小组和营养实验，研究饮食成分与人类癌症发展之间的联系。