The role of mTOR in Ras mediated gliomagenesis

mTOR 在 Ras 介导的胶质瘤发生中的作用

基本信息

批准号：
7494567
负责人：
Jean Nakamura
金额：
$ 12.72万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-08-04 至 2010-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7494567
关键词：
1-Phosphatidylinositol 3-Kinase Achievement Adult Advisory Committees Agar Astrocytes Award Brain Brain Neoplasms California Clinical Commit Comprehensive Cancer Center Databases Development Doctor of Medicine Doctor of Philosophy Glioma Gliomagenesis Human In Vitro Laboratories Laboratory Study Malignant Glioma Mediating Mentors Mentorship Messenger RNA Names National Cancer Institute Neurosurgical Procedures Pathway interactions Phosphoinositide-3-Kinase, Catalytic, Gamma Polypeptide Phosphotransferases Physicians Principal Investigator Program Development Radiation Oncology Research Residencies Resistance Resources Retroviridae Role San Francisco Scientist Signal Transduction Sirolimus Specialized Program of Research Excellence Testing Training Universities Upper arm base career cell transformation human FRAP1 protein in vivo inhibitor/antagonist instructor mTOR Inhibitor mutant professor programs small hairpin RNA therapeutic target tumorigenesis vector control

项目摘要

DESCRIPTION (provided by applicant): This proposal describes a five year program for the development of an academic career as a physician-scientist in Radiation Oncology. The principal investigator completed residency training in Radiation Oncology at the University of California, San Francisco, is serving as a Clinical Instructor in the Department of Radiation Oncology at UCSF, and will be promoted to Assistant Professor in July of 2005. The PI practices neuro-radiation oncology treating adults with malignant gliomas while pursuing laboratory studies in gliomagenesis under the mentorship of Dr. Russell O. Pieper. An experimental program examining the role of mTOR in Ras mediated gliomagenesis is combined with didactic studies and focused interactions with the UCSF Brain Tumor Research Center. The research plan tests the hypothesis that Ras mediated gliomagenesis occurs through the Ral signaling arm, resulting in activation of mTOR and its downstream effector elF4E. The translational targets upregulated by elF4E activity may represent important therapeutic targets in the treatment of malignant gliomas, and will be assessed. The outlined research plan and career development activities will occur at the UCSF Comprehensive Cancer Center, a designated National Cancer Institute research center, and the UCSF Brain Tumor Research Center (BTRC), an NCI named Specialized Program of Research Excellence (SPORE). Mentor Russell O. Pieper, Ph.D., Professor in the Department of Neurological Surgery, and co-mentor Mitchel Berger, M.D., Professor in the Department of Neurological Surgery and PI of UCSF's Brain SPORE program, will be joined by David A. Larson, Ph.D., M.D., Professor in the Department of Radiation Oncology, in forming an advisory committee guiding the PI's achievement throughout the award period. The UCSF Department of Radiation Oncology strongly supports the career development activities outlined and has committed clinical and laboratory resources to support the PI's transition to independence.

描述（由申请人提供）：该提案描述了一个为期五年的计划，以发展作为放射肿瘤学医师科学家的学术生涯。 The principal investigator completed residency training in Radiation Oncology at the University of California, San Francisco, is serving as a Clinical Instructor in the Department of Radiation Oncology at UCSF, and will be promoted to Assistant Professor in July of 2005. The PI practices neuro-radiation oncology treating adults with malignant gliomas while pursuing laboratory studies in gliomagenesis under the mentorship of Dr. Russell O.馅饼。一项实验计划，研究了MTOR在RAS介导的胶质作用中的作用，与教学研究和与UCSF脑肿瘤研究中心的相互作用相结合。研究计划检验了RAS介导的神经胶作用的假设是通过RAL信号传导组发生的，从而导致MTOR激活及其下游效应ELF4E。 ELF4E活性上调的翻译目标可能代表了治疗恶性神经胶质瘤的重要治疗靶标，并将评估。概述的研究计划和职业发展活动将在UCSF综合癌症中心，指定的国家癌症研究中心和UCSF脑肿瘤研究中心（BTRC）（BTRC），这是一个名为“专业研究卓越研究”（SPORE）的NCI。导师Russell O. Pieper博士，神经外科系教授和UCSF脑孢子计划的神经外科和PI教授的M.D. Co-Mitchel Berger，将由David A. D. D. David A.D.，M.D.，M.D.，整个委员会的委员会指导。 UCSF辐射肿瘤学部强烈支持概述的职业发展活动，并致力于临床和实验室资源，以支持PI向独立的过渡。