The Psychosocial & Genetic Basis of Estrogen Metabolism & Blood Pressure in Aging

社会心理

基本信息

批准号：
7479583
负责人：
CHRISTOPHER MAURICE MASI
金额：
$ 11.91万
依托单位：
UNIVERSITY OF CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-08-15 至 2012-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7479583
关键词：
17p Acute Address Adult Affect Age Aging Alcohol consumption Anger Animals Antihypertensive Agents Behavioral Behavioral Genetics Biological Markers Biology Black race Blood Blood Pressure Blood Vessels COMT gene CYP1B1 gene CYP3A4 gene Cardiovascular Diseases Cardiovascular system Catechol O-Methyltransferase Catecholamines Characteristics Chicago Chronic Cohort Studies Coronary Arteriosclerosis Coronary heart disease Data Demographic Aging Dietary Sodium Disease Education Elderly Endocrinology Ensure Enzymes Estradiol Estrogen Metabolism Estrogens Ethnic Origin Exercise Family history of Framingham Heart Study Funding Gender Gene Expression Genes Genetic Genetic Determinism Genetic Predisposition to Disease Geriatric Psychiatry Glucocorticoids Goals Health Hormones Hostility Human Hypertension Hypertension induced by pregnancy Incidence Individual Inherited Intake Life Link Loneliness Low income Marital Status Mediator of activation protein Menopausal Status Menopause Mental Depression Mentorship Mineralocorticoids Modeling Myocardial Infarction Netherlands Nucleotides Numbers Obesity Outcome Pathway interactions Pattern Pharmaceutical Preparations Population Postmenopause Prevalence Production Psychological Stress Psychosocial Factor Race Range Registries Research Research Personnel Risk Risk Factors Sampling Serum Single Nucleotide Polymorphism Smoking Stress Stroke Supplementation Syndrome Tobacco use Training Twin Multiple Birth Urine Vasodilation Woman Women&apos s Health age related base cardiovascular disorder risk cohort design diet and exercise dietary excess disability heart disease risk men middle age older men pressure programs psychologic psychosocial response social urinary young adult

项目摘要

DESCRIPTION (provided by applicant): Despite the declining prevalence of chronic disability among older individuals, age continues to be associated with risk of hypertension and hypertension-related diseases, including coronary artery disease and stroke. In this K08 application, the PI will aggressively explore the mechanisms underlying age-related hypertensive disease, especially among those at highest risk. The theoretical underpinnings of the proposed research are based upon data generated by the PI within the Chicago Health, Aging, and Social Relations Study (CHASRS). Funded by the NIA and directed by Dr. John Cacioppo, this study seeks to explain the effect of psychosocial factors, including loneliness, on age-related changes in systolic blood pressure (SBP). Recent data from CHASRS indicate that loneliness and hostility are associated with urinary estrogen metabolite concentrations and these concentrations are associated with SBP. Because diet, exercise, and stress hormones can influence estrogen metabolism, it is hypothesized that many risk factors for hypertension are associated with estrogen metabolism and that serum levels of estrogen metabolites are associated with SBP. The specific aims are designed to explore these hypotheses in the CHASRS cohort and validate them in a larger cohort from the Netherlands Twin Registry. Specific Aim 1 is to determine which serum estrogen metabolite or combination of serum estrogen metabolites best predicts systolic blood pressure in middle aged and older men and women. Specific Aim 2 is to determine the degree to which serum estrogen metabolite concentrations are correlated with urinary estrogen metabolite concentrations. Specific Aim 3 is to determine whether single nucleotide polymorphisms (SNP's) of genes which encode specific estrogen metabolizing enzymes predict the serum concentrations of the estrogen metabolites most closely associated with systolic blood pressure. Specific Aim 4 is to determine the extent to which estrogen metabolites explain the associations between established hypertension risk factors and systolic blood pressure in middle aged and older men and women. Completion of these aims, as well as mentorship by Dr. Cacioppo and additional training in psychology, geriatrics, endocrinology, vascular biology, and genetics, will ensure the PI develops into an independent clinician investigator with expertise in the demographic, psychosocial, and genetic determinants of estrogen metabolism and age-related blood pressure changes.

描述（由申请人提供）：尽管老年人慢性残疾的患病率下降，但年龄仍与高血压和高血压相关疾病（包括冠状动脉疾病和中风）的风险有关。在此K08应用中，PI将积极探索与年龄相关的高血压疾病的基本机制，尤其是在风险最高的人中。拟议研究的理论基础是基于PI在芝加哥健康，老龄化和社会关系研究（CHASR）中产生的数据。该研究由NIA资助，由John Cacioppo博士指导，旨在解释包括孤独感，包括孤独感，包括年龄相关的收缩压变化（SBP）的影响。 CHASR的最新数据表明，孤独和敌意与尿中雌激素代谢产物浓度有关，这些浓度与SBP有关。因为饮食，运动和压力激素会影响雌激素代谢，所以假设许多高血压危险因素与雌激素代谢有关，并且血清代谢物的血清水平与SBP有关。该特定目的旨在探索CHASRS队列中的这些假设，并在荷兰双胞胎登记中心的较大队列中验证它们。具体目的1是确定哪种血清雌激素代谢产物或血清雌激素代谢物的结合最能预测中年和老年男性和女性的收缩压。具体目标2是确定血清雌激素代谢产物与尿中雌激素代谢产物浓度相关的程度。具体目的3是确定编码特定雌激素代谢酶的基因的单核苷酸多态性（SNP）是否预测雌激素代谢物的血清浓度与收缩压最紧密相关。具体目的4是确定雌激素代谢物在多大程度上解释中年和年龄较大的男性和女性的已建立高血压风险因素与收缩压之间的关联。 Cacioppo博士的这些目标以及心理学，老年医学，内分泌学，血管生物学和遗传学的其他培训的完成，还将确保PI发展成为具有人口统计学，心理社会和遗传确定性的雌激素分类和年龄和年龄较高层次血液层状血液层状的独立临床研究者。