CLINICAL RESEARCH INFRASTRUCTURE

临床研究基础设施

• 批准号: 7493852
• 负责人: GARY Lee FRANCIS
• 金额: $ 23.92万
• 依托单位: CLEVELAND CLINIC LERNER COM-CWRU
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7493852
• 关键词: Administrator; Biochemistry; Blood; Blood Platelets; Classification; Clinic; Clinical; Clinical Data; Clinical Research; Computers; Coronary Arteriosclerosis; DNA analysis; Data; Databases; Family; Family Physicians; Functional disorder; Genes; Genetic; Goals; Human Resources; Leadership; Link; Longitudinal Studies; Molecular Genetics; Nursing Research; Patients; Physicians; Recruitment Activity; Research; Research Ethics Committees; Research Infrastructure; Resistance; Sampling; Scientist; Site; Thrombosis; Time; clinical phenotype; design; experience; follow-up; improved

The Clinical Infrastructure Core is an indispensable component of the SCCOR proposal. It is the unifying link that serves each Project in a very specific manner by providing blood for DNA analysis and assorted biochemistry determinations. Just as importantly, the Clinical Infrastructure Core collects, collates, files and retrieves all clinical data, thereby matching each scientific analysis to key clinical information. Moreover, the Clinical Infrastructure Core is responsible for recruiting patients, controls, and unique families for longitudinal study. It is also responsible for the systematic follow-up of these patients and their families. In reality, this is an enormous task, requiring the multiple interactions with patients, families, physicians, research nurses, scientists, IRBs and administrators. Hundreds of samples will be acquired, stored, retrieved and analyzed. An exceptionally large database of clinical, demographic, angiographic, electrocardiographic and echocardiographic material will be generated and maintained. The group at the Cleveland Clinic has already assembled such an organization on site in the form of GeneBank, GeneQuest, CHARISMA and carotid stenting. We have now several years of experience with these two large and important data repositories, generously maintained by strong institutional support. We have space and a large cadre of research nurses, computers, technicians and some physicians to operate this labor-intensive infrastructure. Over time, its operational aspects have improved, and important new data on genes and coronary artery disease are currently emerging. We now have an opportunity with the SCCOR to expand our research goals and further link our clinical phenotype information in the data banks to the genetic and molecular pathophysiology of coronary artery disease. The Clinical Infrastructure Core is clearly essential to this end. We believe that under the able leadership of Drs. Gary Francis and our many dedicated personnel, that we can leverage our unique experience with GeneBank and GeneQuest to focus on new and tightly integrated SCCOR projects designed to explore and better understand the genetics of thrombosis and resistance to anti-platelet agents.

临床基础设施核心是SCCOR建议的必不可少的组成部分。这是统一的链接 通过提供血液进行DNA分析和各种各样的血液，以非常具体的方式为每个项目提供服务 生物化学确定。同样重要的是，临床基础设施核心收集，整理，文件和 检索所有临床数据，从而将每个科学分析与关键临床信息匹配。而且， 临床基础设施核心负责招募纵向患者，对照和独特的家庭 学习。它还负责这些患者及其家人的系统随访。实际上，这是一个 巨大的任务，需要与患者，家庭，医师，研究护士，科学家， IRB和管理员。将获取，存储，检索和分析数百个样本。一个 临床，人口统计学，血管造影，心电图和超声心动图的极大数据库 材料将产生和维护。克利夫兰诊所的小组已经组装了这样的 以Genebank，Genequest，Charisma和Carotid支架的形式进行现场组织。我们现在有 这两个大型重要数据存储库的经验数年，慷慨地维护 强大的机构支持。我们有空间和大量的研究护士，计算机，技术人员和 一些医生经营这种劳动密集型基础设施。随着时间的流逝，其运营方面有所改善， 目前正在出现有关基因和冠状动脉疾病的重要新数据。我们现在有一个 SCCOR的机会扩大了我们的研究目标，并将我们的临床表型信息进一步联系 数据库是冠状动脉疾病的遗传和分子病理生理学。临床 基础架构核心显然至关重要。我们相信，在博士的能力领导下。加里 弗朗西斯（Francis）和我们的众多敬业人员，我们可以利用我们在Genebank和 Genequest专注于新的和紧密整合的SCCOR项目，旨在探索和更好地了解 血栓形成的遗传学和对抗血小板药物的抗性。