Effect of Medicinal Plants used by Tribes on Cancer and Bacteria

部落使用的药用植物对癌症和细菌的影响

• 批准号: 7457608
• 负责人: WIM Floris Albert STEELANT
• 金额: $ 20.97万
• 依托单位: NEW MEXICO INST OF MINING & TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7457608
• 关键词: Accounting; Anti-Bacterial Agents; Antineoplastic Agents; Bacteria; Bacterial Infections; Biochemical; Biological; Biological Factors; California; Cause of Death; Cessation of life; Chemical Structure; Disease; Drug Industry; Genus Ligusticum; Goals; Knowledge; Lead; Malignant Neoplasms; Mass Spectrum Analysis; Medicinal Plants; Native Americans; New Mexico; Plant Extracts; Plants; Public Health; Range; Research; Resistance; Resolution; Role; Screening procedure; Source; Staging; Structure; Techniques; Tribes; Work; cancer therapy; cytotoxicity test; interest; novel; pathogen

DESCRIPTION (provided by applicant): The ultimate goal of this proposed work is to find new naturally occurring active components against cancer and bacteria. Cancer is one of the major causes of death in the U.S. and accounts for 22% of all annual deaths. The discovery of new potential anti-cancer drugs and their mechanism of action can lead to significant progress in the treatment of cancer. Interest in the use of natural products as potential sources of antibacterial agents has increased over the last decade due to an urgent need to identify novel substances active towards pathogens with high resistance. The critical role of medicinal plants is being widely recognized in the biochemical and biomedical world as well as in the pharmaceutical industry. However, scientific knowledge concerning biologically active components in medicinal plants is still in its early stages. For centuries, Native American tribes have used medicinal plants to treat a broad range of diseases. Two plants in particular are currently being used by Native Americans in New Mexico, to treat various types of diseases, including cancer: Ligusticum porteri (Osha), and Anemopsis California (Yerba Manza). Significant research regarding Ligusticum porteri and Anemopsis California is extremely limited. The work proposed in this application focuses on I) screening for possible biologically active components against cancer and bacteria; ii) their structure determination. Soxhlet extractions, cytotoxicity tests, biological activity screening, chromatographic separations, NMR and Mass spectrometry, are techniques that will be utilized to scientifically explore these medicinal plants for anticancer and antibacterial components. Narrative Interest in the use of natural products as potential sources of anticancer and antibacterial agents has increased over the last decade due to an urgent need to identify novel substances active towards cancer and pathogens with high resistance. Biological active components of A. California and L. Porteri might be promising as anticancer and/or antitibiotic agents. PUBLIC HEALTH RELEVANCE: Interest in the use of natural products as potential sources of anticancer and antibacterial agents has increased over the last decade due to an urgent need to identify novel substances active towards cancer and pathogens with high resistance. Biological active components of A. Californica and L. Porteri might be promising as anticancer and/or antitibiotic agents.

描述（由申请人提供）：这项拟议工作的最终目标是发现针对癌症和细菌的新天然活性成分。癌症是美国死亡的主要原因之一，占所有年死亡的22％。发现新的潜在抗癌药物及其作用机理可以导致癌症治疗的重大进展。在过去的十年中，人们对使用天然产物作为抗菌剂的潜在来源的兴趣增加，因为迫切需要鉴定出对具有高耐药性病原体活跃的新型物质。药用植物的关键作用在生化和生物医学世界以及制药行业中广泛认可。但是，有关药用植物中生物活性成分的科学知识仍处于早期阶段。几个世纪以来，美国原住民部落一直使用药用植物来治疗广泛的疾病。目前，新墨西哥州原住民目前正在使用两种植物，以治疗各种类型的疾病，包括癌症：Porteri ligusticum Porteri（OSHA）和Anemopsis California（Yerba Manza）。关于齿状porteri和加利福尼亚州的Anemopsis的重大研究极为有限。本应用中提出的工作重点是i）筛选可能针对癌症和细菌的生物学活性成分； ii）它们的结构确定。索克斯提取物，细胞毒性测试，生物活性筛查，色谱分离，NMR和质谱法是将用于科学探索这些药用植物的抗癌和抗菌成分的技术。在过去的十年中，由于迫切需要鉴定出对具有高耐药性的癌症和病原体活跃的新型物质，因此在过去十年中，对使用天然产物作为抗癌和抗菌剂的潜在来源的叙事兴趣增加了。 A. california和L. porteri的生物活性成分可能是抗癌和/或抗生素剂。 公共卫生相关性：对使用天然产品作为抗癌和抗菌剂的潜在来源的兴趣在过去十年中有所增加，因为迫切需要鉴定出对具有高耐药性的癌症和病原体活跃的新型物质。 A. californica和L. porteri的生物活性成分可能是抗癌和/或抗生素剂。