Exercise Treatment for Depressed Youth

抑郁青少年的运动治疗

基本信息

批准号：
7532396
负责人：
CARROLL W HUGHES
金额：
$ 22.49万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-09-17 至 2011-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7532396
关键词：
Abbreviations Accounting Achievement Address Adherence Adolescence Adolescent Adult Adverse effects Advertisements Advocate Aerobic Aerobic Exercise Age Alcohols Ambulatory Care Facilities Antidepressive Agents Arts Attitude Behavior Body Image Cause of Death Child Childhood Clinical Cognitive Community Physician Condition Coronary Count Coupled DSM-IV Data Depressed mood Development Devices Diagnostic and Statistical Manual Disease Dose Drops Effectiveness of Interventions Energy Metabolism Exercise Exercise stress test Family Feasibility Studies Feedback Feeling Fluoxetine Future Gender Goals Heart Illicit Drugs Impairment Individual Institutes Internet Intervention Lead MCC protocol Major Depressive Disorder Manuals Measures Medical center Mental Depression Monitor Morbidity - disease rate NIH Program Announcements Nonparametric Statistics Numbers Online Systems Outcome Outcome Measure Outcome Study Outpatients Participant Patient Self-Report Patients Performance Pharmaceutical Preparations Physical activity Placebos Procedures Process Public Health Randomized Randomized Controlled Trials Rate Recovery Recruitment Activity Relative (related person)Research Project Grants Resistance Risk Role SAS Safety Schools Score Selective Serotonin Reuptake Inhibitor Services Severities Signal Transduction Social Adjustment Standards of Weights and Measures Statistical Models Stretching Suicide Techniques Testing Texas Time Training Week Wrist Writing Youth age group base career children&apos s depression rating scale compare effectiveness cost effective depressive symptoms design early onset functional outcomes impression improved mortality outcome forecast partial response preference prescription document prescription procedure psychosocial response size social therapy development tool treatment program unintended pregnancy

项目摘要

DESCRIPTION (provided by applicant): Major depressive disorder (MDD) is common in adolescents and results in significant morbidity and mortality. Adolescent suicides are the third leading cause of death for this age group typically accounted for by depression. There is a high rate of only partial response to the most commonly used group of antidepressants (SSRIs) and increased controversy regarding their use for this age group. These findings coupled with recent decreased SSRI prescription rates with concomitant increases in suicide, constitutes an important public health problem. And for adolescents, there is a lack of available safe, effective, and easy to use nonmedication treatment alternatives with controlled data. Aerobic exercise can provide a safe, effective, minimal side effect treatment intervention that may be more acceptable to patients and potentially cost effective. This study proposes to 1) develop a depressed adolescent exercise treatment manual based on the recent successful UT Southwestern depressed adult exercise study, 2) evaluate the feasibility of using a standardized aerobic exercise regime to treat nonmedicated clinically depressed adolescents based on adherence and completion rates, 3) establish effect sizes for the primary outcome (the CDRS-R and Actical [energy expenditure data] as well as selected secondary outcomes; [e.g., QIDS-A17, attitudes], and 4) determine whether exercise versus stretching activity leads to clinically meaningful reduction in depressive symptoms and/ or improved psychosocial functioning. The proposed study will consist of providing AEROBIC EXERCISE or PLACEBO STRETCH to mild to moderately depressed nonmedicated adolescents recruited from community physicians, advertisements, and UT Southwestern outpatient clinics. Sixty clinically depressed adolescents of both genders between the ages of 12 -17 years who meet criteria for DSM-IV major depression (CDRS-R = 36 =70 and CDI-S = 4) will be randomized to an aerobic dose exercise or a placebo stretch condition for 12 weeks. Based on current recruitment, and rates achieved in the UT Southwestern adult depression exercise study at the Cooper Institute in Dallas, we anticipate at least 60 will be randomized to the 12 weeks exploratory feasibility trial in the allotted time. Comprehensive state of the art processes for monitoring adherence with web-based tools and Actical 24/7 monitoring are coupled with motivational techniques for depressed youth to assure a successful completion rate.

描述（由申请人提供）：主要抑郁症（MDD）在青少年中很常见，并导致显着的发病率和死亡率。青少年自杀是该年龄段的第三大死亡原因，通常由抑郁症解释。对最常用的抗抑郁药（SSRI）组的部分反应率很高，并且在对该年龄段的使用情况下的争议增加了。这些发现以及最近的SSRI处方率下降，自杀的同时增加，这是一个重要的公共卫生问题。对于青少年来说，缺乏可用的安全，有效且易于使用的非医学处理替代方案。有氧运动可以提供安全，有效，最小的副作用治疗干预措施，该干预措施可能对患者更容易接受，并且可能具有成本效益。 This study proposes to 1) develop a depressed adolescent exercise treatment manual based on the recent successful UT Southwestern depressed adult exercise study, 2) evaluate the feasibility of using a standardized aerobic exercise regime to treat nonmedicated clinically depressed adolescents based on adherence and completion rates, 3) establish effect sizes for the primary outcome (the CDRS-R and Actical [energy expenditure data] as well as selected secondary outcomes; [拟议的研究将包括从社区医生，广告和UT西南门诊诊所招募的有氧运动或安慰剂延伸到轻度至中度抑郁的非受测青少年。符合DSM-IV重大抑郁症标准（CDRS-R = 36 = 70和CDI-S = 4）的两个年龄之间的两种性别的临床抑郁症患者将被随机分为有氧剂量运动或安慰剂伸展病持续12周。根据目前的招聘以及达拉斯库珀研究所的UT西南成人抑郁症运动研究的利率，我们预计在分配的时间内，至少有60个将随机分为12周的探索性可行性试验。通过基于Web的工具和行动24/7监测来监测依从性的全面状态，与沮丧的年轻人的动机技术相结合，以确保成功完成率。