Mechanical and Materials Assessment

机械和材料评估

基本信息

批准号：
7576883
负责人：
ADELE L BOSKEY
金额：
$ 17.3万
依托单位：
HOSPITAL FOR SPECIAL SURGERY
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-03-01 至 2011-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7576883
关键词：
Animal Experiments Animal Model Arts Behavior Biochemical Biological Biological Phenomena Biomedical Engineering Biomedical Research Bone and Cartilage Funding Cartilage Clinical Clinical assessments Collaborations Complement Consultations Development Device or Instrument Development Differential Scanning Calorimetry Discipline Disease Engineering Environment Equipment Evaluation Face Faculty Fourier Transform Goals Growth Histology Image Implant In Situ Institution Joints Knowledge Ligaments Materials Testing Mechanics Methodology Methods Molecular Musculoskeletal Natural regeneration Numbers Operative Surgical Procedures Organ Orthopedics Property Range Recombinants Recording of previous events Research Research Personnel Skeletal system Spatial Distribution Special Hospitals Stimulus Structure Students Support of Research System Techniques Technology Tendon structure Testing Tissue Engineering Tissues Training Universities Update base bone concept implant material in vivo in vivo Model investigator training kinematics multidisciplinary programs radiologist repaired research study response

项目摘要

The Mechanical and Material Assessment Core focuses on providing complementary techniques for determining mechanical properties and performing material characterization of native and engineered orthopaedic tissues, as well as providing in vivo models to study adaptation of these skeletal tissues to mechanical stimuli. Skeletal tissues include bone, cartilage, ligament, menicus and tendon, and accomplish their in vivo function through a wide range of material compositions and mechanical behavior. These tissues are responsive to their biophysical and biochemical environments, adapting their composition and structure. Skeletal function is dictated by the properties of the materials and the spatial distribution of the materials within the structure. Assessing function is fundamental to endeavors aimed at musculoskeletal repair and regeneration, because these attempts will only succeed if mechanical function can be restored. Therefore, the goals of the Mechanical and Material Assessment Core are to provide equipment and methodologies for mechanical testing and material characterization of musculoskeletal tissues and organs; to train investigators in the use and interpretation of these techniques; and, to develop new applications and methodologies to support the research programs of investigators within the Core Center's biomedical research base. New testing methodologies suitable to the biological approaches being used in current and planned experiments by cOre investigators have been developed, particularly for in vivo small animal experiments, to complement techniques (such as micro-CT, histology, and Fourier transform infrared imaging) available in the Center's other research cores. These efforts are periodically reviewed by user groups, which include biomedical engineers, clinicians, biologists, radiologists, chemists, and their students. The result has been an expansion of collaborations among the multidisciplinary biomedical research base and the introduction of new investigators to the capabilities of the core.

机械和材料评估核心重点是提供补充技术确定机械性能并执行本地和工程的材料表征骨科组织，并提供体内模型，以研究这些骨骼组织的适应机械刺激。骨骼组织包括骨骼，软骨，韧带，麦芽麦克林和肌腱，并完成它们的体内功能通过多种材料组成和机械行为。这些组织对它们的生物物理和生化环境有反应，以适应它们的组成和结构。骨骼功能取决于材料的特性和材料的空间分布在结构内。评估功能是旨在旨在肌肉骨骼修复和的努力的基础再生，因为这些尝试只有在可以恢复机械功能的情况下才能成功。所以，机械和材料评估核心的目标是为设备和方法提供肌肉骨骼组织和器官的机械测试和材料表征；培训调查人员在这些技术的使用和解释中；并且，开发新的应用程序和方法论支持核心中心生物医学研究基础中研究人员的研究计划。新的测试方法适用于当前和计划实验中使用的生物学方法已经开发了核心研究人员，特别是为了体内小动物实验，以补充中心的技术（例如微型CT，组织学和傅立叶变换红外成像）其他研究核心。这些努力由用户群体定期审查，其中包括生物医学工程师，临床医生，生物学家，放射科医生，化学家及其学生。结果是扩展多学科生物医学研究基础之间的合作以及新的调查人员掌握了核心能力。