Mucosal Immunology Core

粘膜免疫学核心

基本信息

批准号：
7480739
负责人：
Peter A Anton
金额：
$ 6.05万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-05-15 至 2013-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7480739
关键词：
AIDS prevention Acquired Immunodeficiency Syndrome Advertisements Applications Grants Area Awareness Biological Assay Biopsy Biostatistics Core Blood Blood Screening Blood specimen Books Cells Cervix Uteri Clinical Clinical Trials Colon, Rectum Communities Consent Forms Consult Consultations Core Facility Databases Development Epithelium Fostering Funding Gastroenterology Gastrointestinal tract structure Goals Grant HIV HIV Infections Human Immune response Immunologics Immunology Infection Institutes Knowledge Laboratories Link Lymphocyte Lymphoid Tissue Minority Mononuclear Mucous Membrane Operative Surgical Procedures Pathogenesis Patient Selection Patients Preparation Process Quality Control RNA Recruitment Activity Registries Research Research Design Research Ethics Committees Research Personnel Resources Sampling Seminal fluid Services Site Small Intestines Specimen Stomach Diseases Suspension substance Suspensions Techniques Technology Technology Transfer Testing Time Tissue Procurements Tissue Sample Tissues Tonsil Training United States National Institutes of Health Vaccines Validation Viral Load result Visit Woman chemokine cohort cytokine gastrointestinal innovation interest investigator training microbicide mucosal site novel rectum/anus research study response sample collection virology

项目摘要

The Mucosal Immunology Core Laboratory (MICL) was first proposed and funded in 1998 due to an emerging awareness that mucosal lymphoid tissues were critically important as a reservoir for HIV infection. To our knowledge, this was the first Core facility of its kind in CFAR and continues to be a unique resource nationally. Interested researchers had little access to freshly acquired tissue and there were no validated assays for quantifying tissue HIV viral burden as well as other relevant mucosal immunologic and virologic markers. Since the start of the most recent CFAR renewal 4.5 years ago, the MICL has collected over 8000 mucosal tissue biopsies for study from 362 subjects. An additional 407 MICL encounters include 235 subject visits for screening, blood or semen donation without biopsies and 172 tissue specimens received from collaborators for assays or tissue specimens received from the Tissue Procurement Core Laboratory (TPCL). Also the MICL has supported 21 researchers (8 non-UCLA), 21 grant applications (16 funded), and during the past 2 years the MICL has developed a Clinical Trial Registry of 317 potential subjects for proactive recruitment as needed. This resource in unmatched anywhere and is a very unique CFAR resource for HIV investigators.

粘膜免疫学核心实验室（MICL）于1998年首次提出并资助新兴的意识到，粘膜淋巴组织作为HIV感染的储层至关重要。据我们所知，这是CFAR中此类核心的第一个核心设施，它仍然是独特的资源全国。有兴趣的研究人员几乎无法使用新鲜获得的组织，没有经过验证量化组织HIV病毒负担以及其他相关粘膜免疫和病毒学的测定法标记。自最近4。5年前的CFAR续订开始以来，MICL已收集了8000多个来自362名受试者的研究粘膜组织活检。另外的407 MICL遭遇包括235个主题参观筛查，血液或精液捐赠，没有活检，并从中收到172个组织标本从组织采购核心实验室收到测定或组织标本的合作者（TPCL）。 MICL也支持21名研究人员（8个非核心），21个赠款申请（16个资助）和在过去的两年中根据需要积极招募。此资源在任何地方都无与伦比，是一个非常独特的CFAR 艾滋病毒研究者的资源。