Nutrition, GI and Metabolism

营养、胃肠道和新陈代谢

基本信息

批准号：
7676173
负责人：
Christine A Wanke
金额：
$ 28.38万
依托单位：
MIRIAM HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-07-01 至 2012-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7676173
关键词：
Abdomen Anthropometry Archives Area Binding Biopsy Body Composition Body Weight decreased Bone Density Boston Chest Child Nutrition Cities Cohort Studies Collaborations Communities Competence Complex Creatinine Cryptosporidium Cryptosporidium parvum Data Databases Depression screen Diarrhea Dietary Intervention Dietary intake Disease Drug Kinetics Drug user Dual-Energy X-Ray Absorptiometry Dyslipidemias Educational Activities Energy Metabolism Equilibrium Fatty acid glycerol esters Feces Food Food Access Frequencies Genotype Glucose tolerance test Gonadal Hormones HIV HIV Infections Health Hepatic Hepatitis C Hip region structure Hispanics Histidine Histology Hour Housing Immunoglobulin A In Vitro Indirect Calorimetry Infection Insulin Insulin Resistance International Intestines Isotonic Exercise Label Lactulose Leg Leucine Lipids Malabsorption Syndromes Mannitol Measurement Measures Metabolic Metabolism Methods Micronutrients Modeling Mus Muscle Muscle Cells Neck Neurocognitive Nutrient Nutrition Assessment Nutritional Nutritional status Nutritive Value Obesity Ovum Oxidative Stress Parasites Patients Pepsinogens Perception Peripheral Peripheral Blood Mononuclear Cell Permeability Persons Physical activity Plasma Procedures Production Propionibacterium acnes Publications Questionnaires Reading Records Renal function Reporting Research Research Personnel Resistance Resources Role Sampling Security Serum Services Shapes Site Small Intestines Specimen Standardization Surveys System Techniques Telephone Testing Therapeutic Corynebacterium Parvum Thigh structure Tolbutamide Training Universities Upper arm Visceral Visit Walking Water Woman Xylose absorption cohort cytokine day drug metabolism drug testing enteroaggregative Escherichia coli gastrointestinal gastrointestinal function intravenous glucose tolerance test medical schools metabolomics monoclonal antibody production muscle metabolism named group nutrition oxidation pathogen performance site protein degradation receptor subcutaneous tool urinary

项目摘要

Core F: Nutrition, Metabolism and Gl Core The Nutrition, Metabolism, and Gl Core promotes research on the impact of nutritional status on HIV, the metabolic effects of HIV infection and treatment, and the role of gastrointestinal function in HIV disease. The aims of this Core are to provide expertise in nutritional assessment (dietary intake, body composition measurements), metabolism (insulin resistance, lipid profiles), gastrointestinal function (stool and absorptive studies) and expertise for the HIV research and patient community. The role of the Core has continued to expand as investigators explore new aspects of HIV-related disease, including: nutrient databases for international studies, training in body composition and nutritional assessment, new analysis methods for complex dietary data, depression screening, neurocognitive function, serum micronutrients, assessment of bone density and renal function, measures of oxidative stress, and pharmacokinetics of intestinal and hepatic drug metabolism. The Nutrition/Infection Unit, which houses the Nutrition, Metabolism, and Gl Core, maintains a large database and serum bank with nutritional, metabolic, and gastrointestinal measures in over 800 persons with HIV disease. This resource provides CFAR investigators with the opportunity to do detailed studies in areas of HIV nutrition. The Core continues to attract and train new investigators to nutritional research in HIV in the Tufts-Brown community, nationally, and through international collaborations. The Core continues to disseminate information on nutritional and metabolic aspects of HIV through educational activities in the HIV community, publications, and national meetings. PERFORMANCE SITE(S) (organization, city, state) Tufts University School of Medicine, Boston, MA PHS 398 (Rev. 04/06) Page 257 Form Page 2

核心F：营养，代谢和GL核心营养，代谢和GL核心促进了营养状况对艾滋病毒的影响的研究， HIV感染和治疗的代谢作用，以及胃肠道功能在HIV疾病中的作用。该核心的目的是提供营养评估方面的专业知识（饮食摄入，身体成分测量值），代谢（胰岛素抵抗，脂质特征），胃肠功能（粪便和吸收性研究）和艾滋病毒研究和患者社区的专业知识。核心的角色继续随着研究人员探索与HIV相关疾病的新方面的扩展，包括：国际研究，身体成分培训和营养评估，新的分析方法复杂的饮食数据，抑郁筛查，神经认知功能，血清微量营养素，评估骨密度和肾功能，氧化应激的度量以及肠道和药代动力学肝药物代谢。营养/感染单元，容纳营养，代谢和GL核心，维护一个大型数据库和血清库，并具有营养，代谢和胃肠道测量 800人患有艾滋病毒疾病。该资源为CFAR调查人员提供了做的机会艾滋病毒营养领域的详细研究。核心继续吸引并培训新的调查员在全国范围内和国际合作中，塔夫茨棕色社区的艾滋病毒营养研究。核心继续传播有关艾滋病毒营养和代谢方面的信息艾滋病毒社区，出版物和国家会议的教育活动。绩效网站（组织，城市，州）马萨诸塞州波士顿的塔夫茨大学医学院 PHS 398（修订版04/06）第257页表格2