Sympathetic Nervous System & Metabolism in Older Humans

交感神经系统

• 批准号: 7371018
• 负责人: CHRISTOPHER BELL
• 金额: $ 12.25万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-02-15 至 2010-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7371018
• 关键词: AR gene; Acute; Adenylate Cyclase; Adipose tissue; Adult; Affinity; Age; Aging; Agonist; American Heart Association; Area; Basal metabolic rate; Chronic; Complement; Consult; Development; Development Plans; Dietary intake; Doctor of Philosophy; Elderly; Energy Metabolism; Environment; Exercise; Exposure to; Faculty; Fellowship; Funding; Gene Expression; Genetic Variation; Goals; Human; Individual; Journals; Leptin; Link; Mediating; Mentors; Messenger RNA; Metabolic; Metabolism; Modeling; Molecular; Physiological; Placebos; Plasma; Proteins; Rate; Receptor Signaling; Research; Research Training; Rest; Scientist; Series; Signal Pathway; Signal Transduction; Skeletal Muscle; Structure; Sympathetic Nervous System; Thermogenesis; Training; Translational Research; Week; Work; base; beta-adrenergic receptor; career; day; density; desensitization; energy balance; middle age; programs; response; seal; sedentary; sensory neuron specific sodium channel; skills

DESCRIPTION (provided by applicant): Candidate - The candidate, Christopher Bell, Ph.D., is a physiologist currently supported by an individual postdoctoral fellowship from the American Heart Association. Dr. Bell's past and current research focus has been on the effect of physiological aging on resting and exercise energy expenditure. His immediate goal is to acquire new research and professional skills to help him achieve his long-term goal of developing a successful independent extramurally-funded research program in aging. The proposed K01 development plan should provide Dr. Bell with the necessary training to achieve his goal. Career Development Plan - Dr. Bell's proposed research career development activities consist of: 1) acquiring new research skills associated with and complementary to the proposed research plan; and 2) structured activities including formal course work; attendance and presentation at journal clubs, seminar series, and scientific meetings; and regular interactions with his mentoring team. The overall plan is based on a "translational research" training model. Environment - The environment for Dr. Bell's research training should be outstanding. The sponsor, Dr. Douglas Seals, is a well-established extramurally-funded scientist with a strong record of successful mentoring in biomedical aging research. He is complemented by several consulting mentors who will provide guidance in specific areas of the training plan. Other faculty in aging research enhances the local training environment. Research - The general aim of this research is to increase our understanding of the mechanisms responsible for changes in beta-adrenergic receptor sympathetic nervous system (beta-AR SNS) modulation of resting metabolic rate (RMR) and thermogenesis with aging in adult humans. I will determine the influence of energy flux (the level of dietary intake and energy expenditure while in energy balance), increased beta-AR responsiveness, and beta2-AR gene variants on beta-AR SNS support of RMR and thermogenesis in middle-aged and older adult humans.

描述（由申请人提供）： 候选人 - 候选人 Christopher Bell 博士是一名生理学家，目前获得美国心脏协会个人博士后奖学金的支持。贝尔博士过去和当前的研究重点是生理衰老对休息和运动能量消耗的影响。他的近期目标是获得新的研究和专业技能，以帮助他实现其长期目标，即开发一个成功的独立的外部资助的老龄化研究项目。拟议的 K01 开发计划应该为贝尔博士提供必要的培训以实现他的目标。 职业发展计划——贝尔博士提议的研究职业发展活动包括： 1) 获得与提议的研究计划相关且互补的新研究技能； 2) 结构化活动，包括正式课程作业；出席期刊俱乐部、系列研讨会和科学会议并进行演讲；以及与他的指导团队的定期互动。总体计划基于“转化研究”培训模式。 环境——贝尔博士的研究训练环境应该是优秀的。赞助者道格拉斯·西尔斯博士是一位知名的外部资助科学家，在生物医学衰老研究方面拥有成功指导的良好记录。他还有几位咨询导师作为补充，他们将在培训计划的特定领域提供指导。其他从事老龄化研究的教师改善了当地的培训环境。 研究——这项研究的总体目的是加深我们对β-肾上腺素能受体交感神经系统（β-AR SNS）调节静息代谢率（RMR）和生热作用随成年人衰老而变化的机制的理解。我将确定能量通量（能量平衡时的饮食摄入和能量消耗水平）、增加的 β-AR 反应性以及 β2-AR 基因变异对 β-AR SNS 对 RMR 和产热作用的中年和中年人的支持的影响。年长的成年人。

项目成果

Epigallocatechin-3-gallate increases maximal oxygen uptake in adult humans.

• DOI: 10.1249/mss.0b013e3181bcab6c
• 发表时间: 2010-04
• 期刊: Medicine and science in sports and exercise
• 影响因子: 4.1
• 作者: Richards JC;Lonac MC;Johnson TK;Schweder MM;Bell C
• 通讯作者: Bell C

Short-term sympathoadrenal inhibition augments the thermogenic response to beta-adrenergic receptor stimulation.

短期交感肾上腺抑制增强了对β-肾上腺素能受体刺激的生热反应。

• DOI: 10.1677/joe-10-0152
• 发表时间: 2010
• 期刊: The Journal of endocrinology
• 作者: Newsom,SeanA;Richards,JenniferC;Johnson,TylerK;Kuzma,JessicaN;Lonac,MarkC;Paxton,RogerJ;Rynn,GrantM;Voyles,WyattF;Bell,Christopher
• 通讯作者: Bell,Christopher