Immersed Finite Element Method for haemodynamic medical applications

用于血液动力学医学应用的浸入式有限元方法

• 批准号: EP/F03010X/1
• 负责人: Antonio Gil
• 金额: $ 31.4万
• 依托单位: Swansea University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2008
• 资助国家: 英国
• 起止时间: 2008 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FF03010X%2F1
• 关键词: Immersed; Finite; Element; Method; haemodynamic

The aim of this research is to develop a computational methodology, based on the Immersed Finite Element Method, whereby realistic three-dimensional haemodynamic simulations can be carried out. With this methodology, the complex interaction of a viscous incompressible fluid, such as blood, with a viscoelastic structural membrane, such as human tissue or bi-leaflet or tri-leaflet artificial heart valves, can be computationally modelled in an efficient and robust manner. Highly localised areas of mesh distortion and interpenetration issues between different membrane components, arising from the opening and closure of valves, can be tackled within the methodology. One of the six key objectives of the Department of Health (DH) is 'to improve and protect the health of the population...by securing further reductions in early deaths from coronary heart disease'. It has been shown that further research is essential in tackling the increasing challenges that coronary diseases place on our society. According to the DH, 'the Government is determined to make the UK the best place in the world for health research, development and innovation'. Haemodynamic computational simulation is a fundamental tool from which researchers can gain a better understanding of functional, diagnostic and therapeutic aspects of blood flow. The development of this technique could lead to improvements in the early recognition or prediction of heart muscle failure and a better understanding of atherosclerosis and associated problems. It could also facilitate the design of medical devices such as artificial heart valves and coronary stents.

这项研究的目的是基于沉浸式有限元方法来开发一种计算方法，从而实现了现实的三维血流动力学模拟。通过这种方法，可以以有效且可靠的方式对粘​​弹性液体（例如血液）与粘弹性结构膜（例如人体组织或双叶或三叶叶的人造心脏瓣膜）的复杂相互作用。在方法论中，可以解决由阀门的开口和关闭而产生的不同膜组件之间网格失真和互穿问题的高度局部区域。卫生部（DH）的六个主要目标之一是“通过确保早期死亡的冠心病死亡来改善和保护人口的健康……”。已经表明，进一步的研究对于应对冠状动脉疾病在我们社会上面临的日益增长的挑战至关重要。根据DH的说法，“政府决心使英国成为世界上最好的卫生研究，发展和创新的地方”。血液动力学计算模拟是一种基本工具，研究人员可以从中可以更好地了解血流的功能，诊断和治疗方面。该技术的发展可能会改善心脏肌肉失败的早期识别或预测，并更好地理解动脉粥样硬化和相关问题。它还可以促进人工心脏瓣膜和冠状动脉支架等医疗设备的设计。

项目成果

The Immersed Structural Potential Method for haemodynamic applications

• DOI: 10.1016/j.jcp.2010.08.005
• 发表时间: 2010-11-01
• 期刊: JOURNAL OF COMPUTATIONAL PHYSICS
• 影响因子: 4.1
• 作者: Gil, A. J.;Carreno, A. Arranz;Hassan, O.
• 通讯作者: Hassan, O.

Conference Paper

• DOI: 10.1016/s0987-7983(98)80087-x
• 发表时间: 2009
• 作者: Peter Chan

An enhanced Immersed Structural Potential Method for fluid-structure interaction

• DOI: 10.1016/j.jcp.2013.05.011
• 发表时间: 2013-10-01
• 期刊: JOURNAL OF COMPUTATIONAL PHYSICS
• 影响因子: 4.1
• 作者: Gil, A. J.;Carreno, A. Arranz;Hassan, O.
• 通讯作者: Hassan, O.