Soft Tissue Biomechanical Behavior During Acupuncture in Low Back Pain

针灸治疗腰痛期间的软组织生物力学行为

• 批准号: 7470037
• 负责人: HELENE M LANGEVIN
• 金额: $ 36.16万
• 依托单位: UNIVERSITY OF VERMONT & ST AGRIC COLLEGE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7470037
• 关键词: 3-Dimensional; Abbreviations; Acupuncture Points; Acupuncture Therapy; Acupuncture procedure; Alternative Medicine; Appendix; Back; Behavior; Biomechanics; Bladder; Characteristics; Chronic; Clinical Trials; Condition; Connective Tissue; Data; Development; Disease; Engineering; Frequencies; Future; Gallbladder; Goals; Healed; Human; Image; Image Analysis; Imagery; Leg; Localized; Location; Low Back Pain; Mainstreaming; Measurement; Measures; Meridians; Modeling; Muscle; Nature; Needles; Neuronal Plasticity; Noise; One-Step dentin bonding system; Orthopedics; Other Therapy; Outcome Measure; Pain; Palpation; Patients; Pattern; Physics; Physiological; Process; Radio; Radiology Specialty; Range; Recurrent Low Back Pain; Research Personnel; Robotics; Role; Rotation; Series; Signal Transduction; Structure; Techniques; Testing; Thick; Time; Tissues; Torque; Ultrasonography; base; computerized; healing; human subject; improved; in vivo; multidisciplinary; programs; response; soft tissue; subcutaneous; theories

DESCRIPTION (provided by applicant): The goal of this proposal is to test the overall hypothesis that subjects with chronic or recurrent low back pain (LBP) have an abnormal soft tissue response to acupuncture needling, and that this altered response is associated with abnormal perimuscular connective tissue structure and biomechanics. We will also test whether or not altered needling responses in LBP are generalized, or localized to specific locations as predicted by traditional acupuncture theory. 80 LBP and 80 No-LBP subjects will undergo one testing session using computerized robotic acupuncture needling and ultrasound elastography. Needle torque, force and tissue displacement patterns will be compared in LBP vs. No-LBP at Meridians vs. Non-Meridians and Acupuncture Points vs. Non-Acupuncture Points in the back and leg (Aim 1). We also will evaluate soft tissue structural and biomechanical characteristics in the low back by measuring perimuscular connective tissue thickness, ultrasound signal to noise ratio, structural continuity and biomechanical parameters (stiffness and damping) (Aim 2). Accomplishing the Aims of this study will 1) advance our understanding of acupuncture mechanisms 2) provide a first step toward investigating a new dynamic pathophysiological model for LBP incorporating connective tissue and neuroplasticity and 3) provide objective outcome measures of connective tissue structure and biomechanics that can be used in future clinical trials of acupuncture and other therapies for LBP. Relevance: Despite its widespread use for the treatment low back pain (LBP), the mechanism by which acupuncture may promote healing in this condition remains largerly unknown. This lack of understanding constrains the development of improved treatments and is an obstacle to the integration of acupuncture into the mainstream management of LBP. Moreover, the mechanism of LBP itself is poorly understood, further impairing efforts to investigate treatment mechanisms. This study will provide new, objective measurements of phenomena fundamental to both acupuncture and LBP. Demonstrating that acupuncture needling responses are abnormal in LBP, and understanding why these responses are abnormal will bring us one step closer to understanding 1) why LBP occurs and 2) how acupuncture can promote healing in this common and disabling condition.

描述（由申请人提供）：该提案的目的是检验总体假设，即患有慢性或复发性下背痛的受试者（LBP）对针灸针刺的软组织反应异常，并且这种改变的反应与异常的外围互联网结构组织结构和生物力学有关。我们还将测试LBP中的针刺响应是否被广泛化，或将其本地化为传统针灸理论所预测的特定位置。 80 lbp和80 lobp受试者将使用计算机化的机器人针灸针刺和超声弹力进行一次测试。将在子午线与非合格的LBP与NO-LBP中比较针扭矩，力和组织位移模式，而背面和腿部的非针灸点与非针灸点（AIM 1）。我们还将通过测量周围的结缔组织厚度，超声信号与噪声比，结构连续性和生物力学参数（刚度和阻尼）（AIM 2）来评估下背部的软组织结构和生物力学特征（AIM 2）。实现这项研究的目的是1）提高我们对针灸机制的理解2）为研究新的动态病理生理模型提供了第一步，用于LBP，以结合结缔组织和神经可塑性，3）提供了连接组织结构和生物力学的客观结果，可以在未来的临床试验中用于针刺和其他临床试验，以实现lb和其他lb。相关性：尽管它广泛用于治疗下腰痛（LBP），但针灸可能在这种情况下促进愈合的机制仍然尚不清楚。缺乏理解会限制改进治疗的发展，这是将针灸整合到LBP主流管理中的障碍。此外，LBP本身的机制知之甚少，进一步损害了研究治疗机制的努力。这项研究将为针灸和LBP提供新的，客观的测量现象。证明针灸针对LBP的反应是异常的，并且了解为什么这些反应异常将使我们更接近理解1）为什么LBP发生，以及2）针灸如何在这种常见和残疾状态下促进愈合。