FREE BREATHING 3D CARDIAC MRI

自由呼吸 3D 心脏 MRI

• 批准号: 7563681
• 负责人: Bruno Madore
• 金额: $ 1.22万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-01 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7563681
• 关键词: Address; Algorithms; Arts; Blur; Breathing; Cardiac; Child; Clinical; Code; Collaborations; Complex; Computer Retrieval of Information on Scientific Projects Database; Computer software; Data; Diagnostic; Evaluation; Fatty acid glycerol esters; Financial compensation; Freezing; Funding; Goals; Grant; Heart; Hour; Hybrids; Image; Institution; Instruction; Knowledge; Magnetic Resonance Imaging; Measurement; Mechanical ventilation; Methods; Monitor; Morphologic artifacts; Motion; Myocardium; Patients; Pediatric Hospitals; Performance; Phase; Protocols documentation; Publications; Research; Research Personnel; Resolution; Resources; Respiration; Scanning; Scheme; Sedation procedure; Series; Signal Transduction; Source; Staging; Testing; Three-Dimensional Image; Three-Dimensional Imaging; Time; United States National Institutes of Health; Validation; Work; Writing; concept; heart motion; impression; improved; novel strategies; prevent; programs; reconstruction; research study; respiratory; simulation; volunteer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In cardiac MRI applications, the need to freeze or resolve both cardiac and respiratory motion poses a difficult challenge. We propose a novel approach to detect and correct for the complex respiration-induced motion of the heart, while capturing its beating motion. A respiration compensated, 3D cardiac imaging method will be developed and tested in its ability to evaluate myocardium motion, as compared to our current clinical wall-motion protocol. The specific aims are: 1. To develop and implement a very fast 3D imaging strategy. The algorithms for parallel imaging, for our UNFOLD method and for partial-Fourier imaging will be fused, and the resulting hybrid method will be implemented on a 3D steady-state free-precession (SSFP) imaging sequence. 2. To develop, implement and evaluate further additions to the fast imaging approach developed in Specific Aim 1. Novel strategies will be investigated to suppress fat signal, further suppress potential artifacts and improve spatial/temporal resolution. The resulting fast imaging method will be used to generate time series of 3D cardiac images with temporal resolution sufficient to resolve the respiratory cycle (one frame every 1 to 1.5 s). 3. To develop a method for detecting/correcting respiratory motion in a first step, and generating cardiac-phase images in a second step. The heart respiratory motion will be detected in two complementary ways: A conventional respiration monitoring stretchable belt will provide (non-quantitative) information with very high temporal resolution, while the 3D imaging scheme developed in Specific Aims 1 and 2 will provide a wealth of spatial/geometrical quantitative motionrelated information. Combining the knowledge from these two sources will allow the spatially/temporally complex respiratory-motion of the heart to be detected and correct for. In a second step, the respiration-corrected data will be converted from a time series to a cardiac-phase series of high quality 3D images. 4. To evaluate the method's performance in the task of capturing myocardium motion as compared to the protocol currently in use at our institution, a representative example of the current state-of-the-art. The goal is to verify the hypothesis that our method provides SNR, spatial resolution (which includes spatial blurring) and diagnostic value superior to those of the current protocol. Phantom experiments, simulations and imaging of volunteers and patients will be performed. The evaluation of these results will involve both objective criteria (quantitative measurements) as well as subjective criteria (clinicians' impressions on image quality). Plans going forward Although preliminary results showing the beating heart in 3D in free-breathing volunteers have been obtained, artifacts still limit the usefulness of the corresponding results. We will track down, and hopefully address, the sources of these artifacts. Increases in spatial resolution will also be incorporated into the implementation. Collaboration with the Children's hospital has been established to investigate whether the approach can be used to prevent the need for sedation and mechanical ventilation in children old enough to remain mostly still during a scan, but yet unable to reliably follow breathing instructions. The 2D imaging aspect of this work now seems ready for clinical validation. Benefits of the Collaboration to the NCIGT This project provides one of the applications where the fast-imaging approaches developed as part of the NCIGT Imaging core can be applied. More specifically, it is the first 3D application to be considered, and provides a practical context in which the 3D compatibility of the software we are writing can be tested and improved. Benefits to the Project The NCIGT is providing parallel-imaging software to replace the slow reconstruction programs currently in place (a few hours for a typical 3D time series) by much faster code, which can allow the method to proceed from a proof-of-concept stage to actual tests in a clinical setting. Publications Acknowledging both the R01 and the U41 Grants -B. Madore, W.S. Hoge, R. Kwong. An extension to the UNFOLD method to include free-breathing. Magn Reson Med 55:352-362 (2006). -B. Madore, G. Farneb¿ck, C.-F. Westin, M. A. Dur¿n Mendicuti. A new strategy for respiration compensation, applied toward 3D free-breathing cardiac MR imaging. Magn Reson Imag 24:727-737 (2006).

该副本是使用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这是调查员的机构。 在心脏MRI应用中，冻结或解决心脏和呼吸运动的需求构成了困难的挑战。我们提出了一种新颖的方法，以检测和纠正复杂的呼吸引起的心脏运动，同时捕获其跳动运动。与当前的临床壁感觉方案相比，将开发和测试一种呼吸补偿的3D心脏成像方法。具体目的是： 1。制定和实施非常快的3D成像策略。将融合并行成像的算法，用于我们的展开方法和部分倍数成像，并且将在3D稳态自由泳（SSFP）成像序列上实现所得的混合方法。 2。为了开发，实施和评估特定目标中开发的快速成像方法的进一步添加。将研究新的策略以抑制脂肪信号，进一步抑制潜在的伪影并改善空间/时间分辨率。所得的快速成像方法将用于生成具有暂时分辨率的3D心脏图像的时间序列，足以解决呼吸周期（每1至1.5 s）。 3。开发一种在第一步中检测/纠正呼吸运动的方法，并在第二步中生成心脏相相图像。心脏呼吸运动将以两种完整的方式检测到：常规的呼吸监测可伸展带将提供（非定量）信息，并具有很高的临时分辨率，而在特定目标1和2中开发的3D成像方案将提供大量的空间/几何/几何学定量运动相关信息。将这两个来源的知识结合在一起，将允许检测并纠正心脏的空间/时间复杂的呼吸运动。在第二步中，通过呼吸校正的数据将从时间序列转换为一系列高质量的3D图像。 4。与当前在机构中使用的协议相比，要评估该方法在捕获心肌运动的任务中的性能，这是当前最新技术的代表性示例。目的是验证我们的方法提供SNR，空间分辨率（包括空间模糊）和诊断值优于当前协议的假设。将进行志愿者和患者的幻影实验，模拟和成像。对这些结果的评估将涉及客观标准（定量测量）和主题标准（临床医生对图像质量的印象）。 计划正在进行 尽管已经获得了自由呼吸志愿者中3D的跳动心脏的初步结果，但伪影仍限制了相应结果的有用性。我们将追踪这些文物的来源，并希望解决这些文物的来源。空间分辨率的增加也将纳入实施中。已经建立了与儿童医院的合作，以调查该方法是否可以用来防止镇静和机械通气的需求，足以在扫描过程中大部分保持静止，但仍无法可靠地遵循呼吸指示。现在，这项工作的2D成像方面似乎已经准备好进行临床验证。 与NCIGT合作的好处 该项目提供了可以应用作为NCIGT成像核心一部分开发的快速成像方法的应用之一。更具体地说，它是要考虑的第一个3D应用程序，并提供了一个实用的上下文，其中可以测试和改进我们正在编写的软件的3D兼容性。 对项目的好处 NCIGT正在提供并行成像的软件，以替换当前制定的慢速重建程序（典型的3D时间序列几个小时），这可以更快地代码，这可以使该方法从概念验证阶段阶段进行到临床环境中的实际测试。 出版物承认R01和U41赠款 -b。 Madore，W.S。 Hoge，R。Kwong。展开方法的扩展，包括自由呼吸。 Magn Reson Med 55：352-362（2006）。 -b。 Madore，G。Farneb¿ck，C.-F。 Westin，M。A.Dur¿n Mendicusti。一种新的呼吸补偿策略，用于3D自由呼吸心脏MR成像。 Magn Reson Imag 24：727-737（2006）。