Role of CNS in Modulation of Pelvic Pain Syndrome

中枢神经系统在调节盆腔疼痛综合征中的作用

• 批准号: 7571839
• 负责人: ANTHONY J SCHAEFFER
• 金额: $ 29.07万
• 依托单位: NORTHWESTERN UNIVERSITY AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-15 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7571839
• 关键词: Acute; Acute Pain; Affect; Age; Analgesics; Anatomy; Atrophic; Back Pain; Biological Markers; Brain; Characteristics; Chronic; Chronic Prostatitis; Class; Clinical; Clinical Trials; Cognitive; Condition; Diffusion Magnetic Resonance Imaging; Disease; Economics; Emotional; Exhibits; Face; Foundations; Functional Magnetic Resonance Imaging; Gambling; Gastrointestinal Diseases; Gender; Health; Hypersensitivity skin testing; Impaired cognition; Impairment; Injury; Interstitial Cystitis; Iowa; Irritable Bowel Syndrome; Localized; Location; Magnetic Resonance Imaging; Measures; Mechanics; Medial; Morbidity - disease rate; Nerve Degeneration; Pain; Pain Disorder; Participant; Patients; Pattern; Pelvic Pain; Performance; Pharmacotherapy; Physiology; Prefrontal Cortex; Purpose; Quality of life; Reporting; Resolution; Response to stimulus physiology; Rodent; Role; Severities; Site; Skin; Specificity; Stimulus; Symptoms; Syndrome; Tactile; Testing; Time; Touch sensation; Visceral; Visceral pain; cerebral atrophy; chronic pain; chronic pelvic pain; cognitive function; morphometry; novel; painful bladder syndrome; painful neuropathy; response; social; spontaneous pain; urinary; urologic

As with many chronic pain disorders, Syndromes of Chronic Pelvic Pain (SCPP), which, for the purposes of this proposal, include Urological Syndromes of Chronic Pelvic Pain (UCPPS) [interstitial cystitis (1C), painful bladder syndrome (PBS), chronic prostatitis (CP), chronic pelvic pain syndrome (CPPS)] and a commonly comorbid gastroenterological pain syndrome, Irritable Bowel Syndrome (IBS)] are poorly understood and debilitating disorders for which treatment is mostly empirical and unsatisfactory. In preliminary studies, UCPPS patients exhibited brain atrophy and increased brain activity in the mPFC. These changes in UCPPS are similar-yet-distinct from those seen in Chronic Back Pain (CBP) and are different from acute pain. In addition, differential findings of UCPPS spontaneous pain fluctuations and brain activity, referred pain/hypersensitivity tests, and cognitive tests suggest that UCPPS pain presents a profile distinct from other chronic pain. Similar results have been reported in IBS. Thus, we hypothesize that UCPPS and IBS uniquely impact the brain and that brain markers correlate with clinical parameters of SCPP and are influenced by the location duration and severity of the pelvic pain. To test this hypothesis, we will pursue four aims by characterizing SCPP and age/gendermatched controls in each aim. In Aim 1, brain morphometry will be measured precisely. In Aim 2, local brain activity will be quantified in real time. In Aim 3, cognitive function deficits will be evaluated. And in Aim 4, skin sensitivity will be quantified to assess the specificity of referred pain. Thus, these studies will identify novel brain and cognitive biomarkers of SCPP. These studies will also provide the foundation for targeted pharmacotherapies tailored to SCPP. KEY ABBREVIATIONS SCPP = Syndromes of Chronic Pelvic Pain UCPPS = Urological Chronic Pelvic Pain Syndromes IBS = Irritable Bowel Syndrome CP = Chronic Prostatitis CPPS = Chronic Pelvic Pain Syndrome 1C = Interstitial Cystitis PBS = Painful Bladder Syndrome

与许多慢性疼痛障碍一样，慢性骨盆疼痛（SCPP）的综合症，其目的是 该建议包括慢性骨盆疼痛（UCPPS）的泌尿科综合征[间质膀胱炎（1C），疼痛 膀胱综合征（PBS），慢性前列腺炎（CP），慢性骨盆疼痛综合征（CPP）和通常合并症 胃肠病学疼痛综合征，肠易激综合征（IBS）]知之甚少，并且 衰弱的疾病主要是经验和不满意的。 在初步研究中，UCPPS患者在 MPFC。 UCPP中的这些变化与慢性背痛（CBP）中发现的变化相似，并且是 与急性疼痛不同。另外，UCPPS自发疼痛波动的不同发现和 大脑活动，转介疼痛/超敏反应和认知测试表明UCPPS疼痛呈现 特征与其他慢性疼痛不同。 IBS中也报道了类似的结果。 因此，我们假设UCPP和IBS独特地影响大脑，并且大脑标记 与SCPP的临床参数相关，并受到位置持续时间和严重程度的影响 骨盆疼痛。为了检验这一假设，我们将通过表征SCPP和年龄/鸡皮来追求四个目标 每个目标都在控制。在AIM 1中，将精确测量脑形态计量学。在AIM 2，本地 大脑活动将实时量化。在AIM 3中，将评估认知功能缺陷。并在 AIM 4，将量化皮肤灵敏度，以评估引用疼痛的特异性。因此，这些研究将 识别SCPP的新型大脑和认知生物标志物。这些研究还将为 针对SCPP量身定制的有针对性药物疗法。 关键的缩写 SCPP =慢性骨盆疼痛的综合征 UCPPS =泌尿外科慢性骨盆疼痛综合征 IBS =肠易激综合症 CP =慢性前列腺炎 CPP =慢性骨盆疼痛综合征 1C =间质性膀胱炎 PBS =疼痛的膀胱综合征