Core--Chemical process development

核心--化学工艺开发

• 批准号: 7678428
• 负责人: WEI ZHANG
• 金额: $ 30.74万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7678428
• 关键词: Antioxidants; Chemicals; Chemistry; Development; EUK-134; Grant; Health Services Research; Housing; Human Resources; Hydrogenation; Label; Laboratory Research; Lead; Libraries; Link; Methods; Molecular Probes; Organic Chemistry; Outsourcing; Peptides; Pharmaceutical Preparations; Preparation; Process; Production; Range; Research; Route; Services; Side; Staging; Standards of Weights and Measures; Technology; Work; analog; base; design; drug quality; ethyl pyruvate; inhibitor/antagonist; milligram; pressure; scale up; small molecule

This Core will reside within the labs and offices of Fluorous Technologies, Inc. (FTI), a Pittsburgh-based chemical technology company specializing in synthetic organic chemistry. FTI personnel working on the grant will provide chemistry support services on all five Projects, ranging from production of early-stage chemical discovery libraries at milligram scale to later-stage scale-up of promising lead compounds at gram scale. The Core will also provide general guidance and design input from a chemistry perspective to each of the Projects and Cores as appropriate. There are two main contributions from the Core to the grant: service and research. On the service side, the Core will synthesize in house gram quantities of existing drug candidates, molecular probes and other small molecules needed for laboratory research on all five projects, and will oversee the outsourcing of any synthesis that goes outside of FTI either for reasons of scale or specialized chemistry.

该核心将位于一家专门从事合成有机化学的化学技术公司（FTI）的实验室和办公室内。从事赠款的FTI人员将在所有五个项目中提供化学支持服务， 从毫克量表的早期化学发现库的生产到以克量表的后期铅化合物的后期规模。核心还将从化学的角度向每个项目和核心提供一般指导和设计意见。核心对赠款有两个主要贡献：服务和研究。在服务方面，核心将在房屋革兰氏数量中合成大量现有药物候选物，分子探针和实验室研究所需的其他小分子，用于对所有五个项目进行研究，并将监督出于规模或专业化学的原因外包FTI之外的任何合成。