Coronary heart disease & Anxiety: Prevalence, Relationship

冠状动脉心脏疾病

• 批准号: 7321680
• 负责人: CHERYL N CARMIN
• 金额: $ 15.24万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7321680
• 关键词: Address; Affect; Alcohol consumption; Anxiety; Anxiety Disorders; Area; Arts; Attention; Award; Behavioral; Biological; Biological Process; Biometry; Calcium; Cardiac; Cardiology; Cardiovascular Diseases; Cardiovascular system; Clinic; Comorbidity; Condition; Control Groups; Coronary heart disease; Data; Databases; Depressive disorder; Development; Diagnosis; Diagnostic; Disease; Dysthymic Disorder; Electron Beam Tomography; Elements; Emotional; Emotional Stress; Epidemiology; Frequencies; Goals; Heart Diseases; Heart Rate; Individual; Influentials; Ischemia; Joints; K-Series Research Career Programs; Knowledge; Life Style; Link; Lipids; Literature; Living Wills; Major Depressive Disorder; Measures; Medical; Mental Depression; Mentors; Modeling; Mood Disorders; Morbidity - disease rate; Patient Self-Report; Phase; Positioning Attribute; Prevalence; Process; Psychology; Psychopathology; Psychophysiology; Quality of life; Research; Research Personnel; Risk; Risk Factors; Role; Sampling; Scanning; Severities; Study Subject; Symptoms; Syndrome; Technology; base; cardiovascular risk factor; career; clinically significant; design; experience; heart disease risk; mortality; programs; psychologic; psychosocial; response; sedentary; skills; stomach cardia; trait

DESCRIPTION (provided by applicant): The goals of this career development award are designed enable the candidate to develop a program of independent research examining the relationship between anxiety disorders and coronary heart disease (CHD). This study would contribute to the investigator's long-term career goal of examining the relationship between anxiety disorders and medical illness, such as CHD. There is a relatively well-established link between emotional and behavioral variables and the risk for CHD. Despite the comorbidity of anxiety and depressive disorders, the lines of research investigating these conditions and CHD have remained largely independent of one another. Further, despite it being more prevalent than and often pre-dating the onset of depression, less attention has been paid to the relationship between anxiety and CHD. The existing research focusing on anxiety disorders in those at risk for or who have CHD is limited by the use of descriptive, rather than state-of-the-art diagnostic measures of psychopathology. It remains unclear to what extent clinically significant anxiety disorders serve as independent risk factors and may be influential in the development of CHD. In order to address the risk that anxiety disorders pose in CHD prone individuals, the initial phase of this award will allow the investigator to develop background in areas related to the interface between cardiology and psychology including psychosocial epidemiology, biostatistics, psychophysiological assessment, and scanning technology related to CHD. Existing epidemiological databases that assess CHD will be utilized to determine whether anxiety disorders are independently related to the development of CHD. The 2 nd phase of the award will be used to apply the skills acquired in coursework and in analyzing existing data to execute a study comparing a sample of anxiety disordered subjects to a matched control group based on anxiety symptoms (severity, frequency, duration), cardiac calcium as assessed by electron beam tomography, lipid levels, and heart rate variability. The investigator is in the unique position of having access to individuals who are being screened for CHD using EBT as well as having access mentors and collaborators involved in multicenter cardiovascular research (Drs. Lynda Powell, Peter Buttrick, Kiang Liu, George Kondos), psychophysiological research (Dr. Stephen Porges) and who are experienced in the psychopathology and treatment of anxiety disorders (Dr. Richard Heimberg).

描述（由申请人提供）：该职业发展奖的目标是使候选人能够制定一项独立研究计划，检查焦虑症和冠心病 (CHD) 之间的关系。这项研究将有助于研究者的长期职业目标，即检查焦虑症与先心病等医学疾病之间的关系。情绪和行为变量与冠心病风险之间存在相对明确的联系。尽管焦虑症和抑郁症存在共病，但调查这些疾病和冠心病的研究路线在很大程度上仍然是相互独立的。此外，尽管焦虑症比抑郁症更普遍，而且往往早于抑郁症的发病，但人们对焦虑症和冠心病之间的关系的关注较少。现有的针对有先心病风险或患有先心病的人的焦虑症的研究，受到描述性而非最先进的精神病理学诊断措施的使用的限制。目前尚不清楚临床上显着的焦虑症在多大程度上可以作为独立的危险因素，并可能对冠心病的发展产生影响。为了解决焦虑症对先心病易感人群造成的风险，该奖项的初始阶段将允许研究人员发展与心脏病学和心理学之间的接口相关的领域的背景，包括社会心理流行病学、生物统计学、心理生理学评估和扫描技术与冠心病有关。评估先心病的现有流行病学数据库将用于确定焦虑症是否与先心病的发展独立相关。该奖项的第二阶段将用于应用在课程作业和分析现有数据中获得的技能，以执行一项研究，根据焦虑症状（严重程度、频率、持续时间），将焦虑症受试者样本与匹配的对照组进行比较，通过电子束断层扫描、脂质水平和心率变异性评估心脏钙。研究者处于独特的地位，可以接触到正在使用 EBT 筛查 CHD 的个体，并接触到参与多中心心血管研究的导师和合作者（Lynda Powell 博士、Peter Buttrick、Kiang Liu、George Kondos）、心理生理学研究人员（Stephen Porges 博士）以及在精神病理学和焦虑症治疗方面经验丰富的人（Richard Heimberg 博士）。