Optimal Strategies for Management of HIV Disease

HIV 疾病管理的最佳策略

• 批准号: 7479644
• 负责人: Kenneth Alan Freedberg
• 金额: $ 10.62万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7479644
• 关键词: Address; Africa; Anti-Retroviral Agents; Area; Asia; Caribbean natives; Caribbean region; Caring; Clinical; Clinical Management; Decision Analysis; Developing Countries; Development; Disease; Epidemic; Europe; Faculty; HIV; Human immunodeficiency virus test; International; Investigation; Mentors; Methods; Modeling; Morbidity - disease rate; Opportunistic Infections; Outcomes Research; Pharmaceutical Preparations; Price; Prophylactic treatment; Research; Research Personnel; Role; Structure; Time; Training; United States; Work; career; clinical epidemiology; cost; cost effectiveness; experience; models and simulation; mortality; multidisciplinary; patient oriented; patient oriented research; skills; treatment program

DESCRIPTION (provided by applicant): Improvements in HIV treatment have dramatically reduced AIDS-related morbidity and mortality in the United States and Europe. More recently, lower drug prices and an increased focus on the global HIV epidemic has created tremendous momentum toward the development of HIV treatment programs in less developed countries in Africa, Asia and the Caribbean. With a distinguished track record of patient-oriented HIV outcomes research, Dr. Freedberg proposes to build on over 10 years of experience examining the clinical impact, cost, and cost-effectiveness of alternative HIV care strategies and to expand opportunities for junior investigators to develop skills in these areas. Research will focus in three main areas: optimal management strategies for HIV in the US, the cost-effectiveness of different strategies for HIV testing, and the impact of various strategies for antiretroviral use and opportunistic infection prophylaxis in less developed countries. This proposal has the following three specific aims: 1) To provide mentoring for young investigators in patient-oriented research in HIV disease. 2) To use ongoing multidisciplinary HIV-related modeling and outcomes research as a platform for training young investigators. 3) To utilize these efforts to address critical HIV clinical management questions in a variety of US and international settings. Using methods of clinical epidemiology, decision analysis, and simulation modeling, Dr. Freedberg proposes to expand on the past decade of work to focus added time and energy into questions at the forefront of HIV management throughout the world. By providing increased mentoring to fellows and junior faculty in the methods of outcomes research, Dr. Freedberg will create a multiplicative effect in increasing research capability in this important area of HIV-related patient-oriented investigation.

描述（由申请人提供）：在美国和欧洲，艾滋病毒治疗的改善大大降低了与艾滋病相关的发病率和死亡率。最近，较低的药物价格和对全球艾滋病毒流行的关注越来越大，在非洲，亚洲和加勒比海较不发达国家的艾滋病毒治疗计划的制定方面创造了巨大的动力。 Freedberg博士凭借着以患者为导向的HIV成果研究的杰出记录，旨在以十年来研究替代HIV护理策略的临床影响，成本和成本效益的经验，并扩大初级调查人员的机会，以促进这些领域的技能。研究将重点放在三个主要领域：美国艾滋病毒的最佳管理策略，不同的艾滋病毒测试策略的成本效益以及各种策略对抗逆转录病毒使用和机会性感染预防的影响。该提案具有以下三个具体目标： 1）为年轻研究人员提供指导艾滋病毒疾病研究。 2）使用正在进行的多学科HIV相关的建模和结果研究作为培训年轻研究人员的平台。 3）利用这些努力来解决我们各种各样的美国和国际环境中的关键艾滋病毒临床管理问题。 Freedberg博士使用临床流行病学，决策分析和模拟建模方法，提议扩展过去十年的工作，以将更多的时间和精力集中在全球艾滋病毒管理的最前沿。通过在结果研究的方法中为研究员和初级教师提供更多的指导，Freedberg博士将在提高与HIV相关患者的重要领域的研究能力上产生乘法效应。

项目成果

Assessing the performance of a computer-based policy model of HIV and AIDS.

评估基于计算机的艾滋病毒和艾滋病政策模型的绩效。

• DOI: 10.1371/journal.pone.0012647
• 发表时间: 2010
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Rydzak,CharaE;Cotich,KaraL;Sax,PaulE;Hsu,HeatherE;Wang,Bingxia;Losina,Elena;Freedberg,KennethA;Weinstein,MiltonC;Goldie,SueJ;CEPACInvestigators
• 通讯作者: CEPACInvestigators

Drug efficacy by direct and adjusted indirect comparison to placebo: An illustration by Mycobacterium avium complex prophylaxis in HIV.

与安慰剂进行直接和调整间接比较的药物疗效：以鸟分枝杆菌复合物预防艾滋病毒为例。

• DOI: 10.1186/1742-6405-8-14
• 发表时间: 2011
• 期刊: AIDS research and therapy
• 影响因子: 2.2
• 作者: Chu,Jennifer;Sloan,CarolineE;Freedberg,KennethA;Yazdanpanah,Yazdan;Losina,Elena
• 通讯作者: Losina,Elena

Improving outcomes in state AIDS drug assistance programs.

改善州艾滋病药物援助计划的成果。

• DOI: 10.1097/qai.0b013e3181b16d00
• 发表时间: 2009
• 期刊: Journal of acquired immune deficiency syndromes (1999)
• 作者: Linas,BenjaminP;Losina,Elena;Rockwell,Annette;Walensky,RochelleP;Cranston,Kevin;Freedberg,KennethA
• 通讯作者: Freedberg,KennethA

Provider-initiated HIV testing in rural Haiti: low rate of missed opportunities for diagnosis of HIV in a primary care clinic.

• DOI: 10.1186/1742-6405-4-28
• 发表时间: 2007-11-29
• 期刊: AIDS research and therapy
• 影响因子: 2.2
• 作者: Ivers LC;Freedberg KA;Mukherjee JS
• 通讯作者: Mukherjee JS