Healthy Bodies, Healthy Hearts after Menopause

更年期后健康的身体、健康的心脏

• 批准号: 7488885
• 负责人: Margaret B Conroy
• 金额: $ 15.18万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7488885
• 关键词: Abdomen; Address; Adherence; Ancillary Study; Area; Arts; Behavior; Behavioral Medicine; Blood Vessels; Body Composition; Body Weight decreased; Cardiovascular Diseases; Cardiovascular system; Clinic; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Collection; Complex; Data; Development; Disease; Early Intervention; Effectiveness; Effectiveness of Interventions; Elderly; Electronic Health Record; Employee Strikes; Epidemiology; Exercise Physiology; Future; Genetic; Goals; Hand; Health; Health education; Heart; High Risk Woman; Incidence; Inflammation; Insulin Resistance; Intervention; Intervention Trial; Investigation; Link; Maintenance; Measurement; Measures; Mediating; Medicine; Menopause; Mentored Patient-Oriented Research Career Development Award; Methods; Modeling; Mollies; Morbidity - disease rate; Muscle; Numbers; Obesity; Outcome; Outcome Measure; Overweight; Participant; Pathway interactions; Patients; Physical Education; Physical activity; Physiological; Play; Population; Postmenopause; Prevention Research; Primary Health Care; Psychosocial Factor; Randomized; Randomized Controlled Trials; Recruitment Activity; Research; Research Methodology; Research Personnel; Risk; Risk Factors; Role; Support System; System; Testing; Time; Training; Translating; Translational Research; Translations; Universities; Weight; Woman; abdominal fat; abstracting; behavior change; cardiovascular disorder risk; career; cohort; experience; health care delivery; improved; innovation; lifestyle intervention; lipid metabolism; men; mortality; novel; novel strategies; nutrition; prevent; professor; programs; response; size; skills; therapy design; trend; young adult

DESCRIPTION (provided by applicant): Dr. Margaret (Molly) B. Conroy is an Assistant Professor of Medicine and Epidemiology at the University of Pittsburgh. She is applying for a Mentored Patient-Oriented Research Career Development Award (K23) in order to become an independent clinical investigator. Her proposal focuses on the relationships between physical activity, abdominal and muscular adiposity and cardiovascular disease (CVD) in women after menopause. Women are a high-risk population, as they are more likely to be physically inactive than men, a disparity that becomes more striking with advancing age. Following menopause, the incidence of CVD in women increases, while participation in regular physical activity declines. Further investigation is warranted of the pathways through which physical activity impacts CVD risk after menopause, particularly those incorporating body composition and potentially modifiable psychosocial factors. Dr. Conroy will examine these relationships and implement and evaluate a physical activity intervention in a clinical setting by pursuing three specific aims. Aim #1 will determine whether abdominal and muscular adiposity mediate the relationship between physical activity and subclinical cardiovascular disease risk in a cohort of postmenopausal women. Aim #2 will examine the relationships between changes in physical activity, abdominal and muscular adiposity and cardiovascular disease risk after an intensive lifestyle intervention. Aim #3 will involve a randomized, controlled physical activity intervention for early postmenopausal women that adapts clinical trial methods and translates them to the primary care patient population and practice setting. Aim #1 will be addressed by an ancillary study in the Women on the Move through Activity and Nutrition (WOMAN) cohort. Aim #2 will be addressed in the Slow Adverse Vascular Effects (SAVE) study. Aim #3 wiN be addressed by recruiting an intervention cohort from Dr. Conroy's primary care clinic. Experts in the fields of physical activity and CVD epidemiology, translational research, behavioral medicine and intervention design will supervise Dr. Conroy's career development. She will receive specific training in (1) collection, analysis and interpretation of state-of-the art outcome measures of obesity and subclinical cardiovascular disease; (2) theoretical background and hands-on skills necessary for planning and executing physical activity and lifestyle interventions; and (3) translational research, focused on strategies, collaborative models and technical support systems for implementing lifestyle interventions in clinical systems. A better understanding of the mechanisms linking physical activity, adiposity and CVD after menopause and innovative physical activity promotion strategies in this high-risk population are critical steps towards advancing cardiovascular health in women. (End of Abstract)

描述（由申请人提供）：玛格丽特（Molly）博士B. Conroy是匹兹堡大学医学与流行病学助理教授。她正在申请一个受过指导的注重患者研究职业发展奖（K23），以成为独立的临床研究者。她的提议着重于更年期后女性的体育活动，腹部和肌肉肥胖与心血管疾病（CVD）之间的关系。女性是高风险人口，因为她们比男性更有可能身体不活跃，这一差距随着年龄的增长而变得更加惊人。更年期后，女性CVD的发生率增加，而参加常规体育锻炼的情况下降。保证了对体育活动影响更年期后CVD风险的途径，特别是那些融合身体成分和潜在可修改的社会心理因素的途径。 Conroy博士将通过追求三个特定目标来检查这些关系，并在临床环境中实施和评估体育活动干预。 AIM＃1将确定绝经后妇女队列中腹部和肌肉肥胖是否介导体育锻炼与亚临床心血管疾病风险之间的关系。 AIM＃2将检查体育锻炼，腹部和肌肉肥胖和心血管疾病的风险之间的关系。 AIM＃3将涉及对绝经后妇女的随机，受控的身体活动干预措施，该妇女适应临床试验方法，并将其转化为初级保健患者人群和练习设置。 AIM＃1将由妇女进行的辅助研究解决，以通过活动和营养（女性）队列进行。 AIM＃2将在缓慢的不良血管效应（保存）研究中解决。 AIM＃3胜利将通过从Conroy博士的初级保健诊所招募干预队列来解决。体育活动和CVD流行病学，转化研究，行为医学和干预设计领域的专家将监督Conroy博士的职业发展。她将在（1）收集，分析和解释肥胖和亚临床心血管疾病的最新结果指标方面接受特定的培训； （2）规划和执行体育锻炼和生活方式干预所必需的理论背景和动手技能； （3）转化研究，专注于在临床系统中实施生活方式干预措施的策略，协作模型和技术支持系统。更好地理解了在这种高危人群中，更年期和创新的体育锻炼促进策略相关的机制，这是促进女性心血管健康的关键步骤。 （抽象的结尾）