Complications of Chronic Viral Infections

慢性病毒感染的并发症

• 批准号: 7494841
• 负责人: MARSHALL J GLESBY
• 金额: $ 17.16万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7494841
• 关键词: AIDS clinical trial group; Area; Blood Banks; Brazil; Chronic; Clinic; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Cohort Studies; Collaborations; Commit; Cross-Sectional Studies; Diabetes Mellitus; Disease; Doctor of Philosophy; Double-Blind Method; Education; Environment; Faculty; Fatty acid glycerol esters; Funding; Genotype; Goals; Grant; HIV; HIV-1; HTLV-1 Infection; Hepatitis C virus; Homocysteine; Homocystine; Infection; Insulin Resistance; International; Medial; Medical Students; Mentors; Metabolic; Methods; Mid-Career Clinical Scientist Award (K24); National Institute of Allergy and Infectious Disease; Natural History; Newly Diagnosed; Oxidative Stress; Patients; Pilot Projects; Pioglitazone; Plasma; Postdoctoral Fellow; Protocols documentation; Public Health; Randomized; Research; Research Design; Research Personnel; Research Project Grants; Resources; Ribavirin; Stream; Thick; Time; Training; Tropical Disease; Universities; Virus Diseases; Visceral; Woman; base; career; design; improved; in vivo; international center; member; neglect; next generation; patient oriented research; placebo controlled study; programs; r-hGH-M; rosiglitazone; skills

DESCRIPTION (provided by applicant): The goal of this application is to expand my mentoring of medical students, post-doctoral fellows, and junior faculty in the conduct of patient-oriented research. My career has been devoted to conducting high quality patient-oriented research in the area of complications of chronic viral infections, with a focus on HIV disease. As the recipient of outstanding mentoring and training, including a PhD in Clinical Investigation, I am committed to training the next generation of clinical investigators. My longstanding research in the area of metabolic complications of HIV and its therapy and recent research in another chronic retroviral infection, HTLV-1 infection in Brazil, as detailed in the following specific aims, will serve as vehicles for training clinical investigators domestically and internationally: 1) To investigate metabolic complications of HIV disease and its therapy; 2) To investigate metabolic complications of HCV/HIV co-infection; and, 3) To characterize the clinical manifestations of HTLV-1 infection. Specific clinical research projects that are funded by R01-DK065515, a supplement from NIAID, and the AIDS Clinical Trials Group, in conjunction with an outstanding institutional environment and resources for education, will enable me to train the next generation of investigators in high quality, hypothesis-driven, patient-oriented research. Furthermore, support from the Fogarty International Center and a T32 training grant will provide a steady stream of high quality domestic and international trainees. This application describes a detailed mentoring plan for trainees, which includes the K30 Masters in Clinical Investigation program for which I developed and co-direct a Clinical Trials course. At this juncture in my career, the protected time afforded by a K24 award is critical to allow me to expand my domestic and international clinical research programs and mentoring activities. To date, I have been able to use my methodologic skills to improve the quality of patient-oriented research being conducted as part of the longstanding NIH-funded Cornell-Bahia collaboration in tropical diseases research. The K24 award will permit me to increase collaborations with colleagues at the Federal University of Bahia in Brazil, assisting in the design, conduct, and analysis of patient-oriented research in neglected tropical diseases of public health importance, including HTLV-1 infection.

描述（由申请人提供）：本申请的目的是扩大我对医学生，博士后研究员和初级教师的指导。我的职业生涯一直致力于在慢性病毒感染并发症领域进行高质量的以患者为导向的研究，重点是HIV疾病。作为杰出的指导和培训的接受者，包括临床研究的博士学位，我致力于培训下一代临床研究者。我在艾滋病毒代谢并发症及其治疗方面的长期研究以及在另一种慢性倒流感染感染巴西的HTLV-1感染中的最新研究，如以下具体目的所述，将作为培训临床研究人员在国内和国际上培训临床研究人员的工具：1），以研究HIV疾病及其治疗的代谢复杂性； 2）研究HCV/HIV共感染的代谢并发症； 3）表征HTLV-1感染的临床表现。 由NIAID补充剂R01-DK065515资助的特定临床研究项目，以及艾滋病临床试验小组，以及杰出的机构环境和教育资源，将使我能够通过高质量，假设驱动的患者，以患者为方便的研究来培训下一代研究人员。此外，Fogarty International Center和T32培训补助金的支持将提供高质量的国内和国际学员。该应用程序描述了针对受训者的详细指导计划，其中包括临床调查计划中的K30硕士学位，我开发并共同指导了临床试验课程。在我职业生涯的这个关头，K24奖提供的受保护时间对于让我扩大国内和国际临床研究计划和指导活动至关重要。迄今为止，我已经能够利用自己的方法学技能来提高作为NIH资助的热带疾病研究中长期以来的NIH资助的Cornell-Bahia合作的一部分进行的以患者为导向的研究的质量。 K24奖将使我能够增加巴西巴伊亚联邦大学的同事的合作，从而协助对忽视的公共健康重要性热带疾病的设计，行为和分析，包括HTLV-1感染。