Secondary Analysis of Alcohol and Sexual and Injection HIV-risk Behaviors

酒精、性行为和注射艾滋病毒风险行为的二次分析

• 批准号: 7188197
• 负责人: KAMYAR ARASTEH
• 金额: $ 12.02万
• 依托单位: BETH ISRAEL MEDICAL CTR (NEW YORK)
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-30 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7188197
• 关键词: AIDS /HIV test; AIDS education /prevention; AIDS therapy; HIV infections; alcoholic beverage consumption; alcoholism /alcohol abuse; antiAIDS agent; behavioral /social science research tag; health care service utilization; high risk behavior /lifestyle; human data; intravenous drug abuse; sex behavior; substance abuse related behavior; therapy compliance

DESCRIPTION (provided by applicant): Alcohol consumption has important implications for the management of the HIV epidemic. Several studies suggest that alcohol use is associated with HIV risk and decreased probability of antiretroviral treatment. However, perhaps because of the prominence of injection risks in HIV infection, the role of alcohol in HIV- related processes in drug users has not been adequately investigated. Addressing this problem is a critical public health concern, because alcohol use is prevalent among drug users, and injection drug users constitutes a large proportion of HIV infections. Our long-term goal is to elucidate the role of alcohol in these HIV-related processes among drug user population. We have an opportunity to analyze data collected in three studies from more than 15,000 drug users that can uniquely illuminate the relation of alcohol to HIV in this population over a period of 14 years of the HIV epidemic and across 14 different national settings. We hypothesize that alcohol use: 1) increases HIV infection risk behaviors, 2) reduces receiving antiretroviral treatment and adherence to it, and 3) shows different patterns of association with risk behaviors over time and across countries. We have five specific aims: 1) Determine the association of alcohol use with sexual risk behaviors, by examining the association of levels of alcohol consumption and sexual risks. 2) Determine the association of alcohol use with injection risk behaviors, by assessing the relation of levels of alcohol consumption with injection risks. 3) Determine the association of alcohol use with HIV testing and probability of antiretroviral treatment. 4) Compare the relation of alcohol use and HIV risk behaviors among injection drug users in a "prevention program rich" environment to "prevention program poor" environment. 5) Determine the relationships between alcohol use and HIV risk behaviors in different developing and transitional countries. This goal of our research is to reduce alcohol-related effects on HIV and as such addresses the mission of the agency. The research would also provide critical information for public health policy regarding the role of alcohol in HIV in both the U.S. and in developing and transitional countries.

描述（由申请人提供）：饮酒对于艾滋病毒流行的管理具有重要影响。多项研究表明，饮酒与艾滋病毒风险和抗逆转录病毒治疗的可能性降低有关。然而，也许由于艾滋病毒感染中注射风险的突出，酒精在吸毒者艾滋病毒相关过程中的作用尚未得到充分研究。解决这一问题是一个重要的公共卫生问题，因为酗酒在吸毒者中很普遍，而注射吸毒者在艾滋病毒感染者中占很大比例。我们的长期目标是阐明酒精在吸毒人群中这些与艾滋病毒相关的过程中的作用。我们有机会分析三项研究中收集的超过 15,000 名吸毒者的数据，这些数据可以独特地阐明在艾滋病毒流行的 14 年期间以及在 14 个不同的国家/地区中酒精与艾滋病毒之间的关系。我们假设饮酒：1）增加艾滋病毒感染风险行为，2）减少接受抗逆转录病毒治疗和坚持治疗，3）随着时间的推移和不同国家，饮酒与风险行为的关联模式不同。我们有五个具体目标：1）通过检查饮酒水平与性风险之间的关联，确定饮酒与性风险行为之间的关联。 2) 通过评估饮酒水平与注射风险的关系，确定饮酒与注射风险行为的关联。 3) 确定饮酒与 HIV 检测和抗逆转录病毒治疗可能性的关联。 4) 比较“预防计划丰富”环境和“预防计划匮乏”环境中注射吸毒者的饮酒和艾滋病毒危险行为的关系。 5) 确定不同发展中国家和转型国家的饮酒与艾滋病毒危险行为之间的关系。我们研究的目标是减少酒精对艾滋病毒的影响，从而解决该机构的使命。该研究还将为有关美国以及发展中国家和转型国家酒精在艾滋病毒中的作用的公共卫生政策提供重要信息。