Radiographic guidance of new cerebral aneurysm stent

新型脑动脉瘤支架的影像引导

• 批准号: 7222689
• 负责人: STEPHEN RUDIN
• 金额: $ 62.59万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-15 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7222689
• 关键词: Aneurysm; Angiography; Animal Model; Area; Blood Vessels; Blood flow; Cataloging; Catalogs; Categories; Catheters; Cerebral Aneurysm; Characteristics; Classification; Clinical; Computers; Condition; Contrast Media; Development; Device Designs; Device or Instrument Development; Devices; Diagnostic Imaging; Dyes; Environment; Evaluation; Goals; Hemorrhage; Human; Image; Image Analysis; Imagery; Implant; Insurance Claim Review; Liquid substance; Literature; Localized; Mechanics; Methods; Modeling; Modification; Nature; Neck; Optics; Pattern; Peer Review; Perforation; Placement; Porosity; Positioning Attribute; Procedures; Publishing; Recurrence; Resolution; Risk; Secrecy; Shapes; Standards of Weights and Measures; Stents; Stress; Surveys; Thrombosis; Time; Velocimetries; Viscosity; base; clinical application; density; design; desire; detector; imaging detector; improved; innovation; particle; prototype; research study; size; treatment planning

DESCRIPTION (provided by applicant): The limitations of radiographic visualization and the lack of consideration of the influence of stentt deployment on details of blood flow have limited stentt design to forms which are uniform and circularly symmetric. Yet some of the most important potential applications of stents such as in the treatment of aneurysms are inherently non-uniform and non-symmetric in nature. In this project, the design of innovative asymmetric stents and their deployment enabled by guidance with new high resolution x-ray image detectors are investigated. In particular, the limitations and accuracy in localizing the rotational orientation as well as the longitudinal distance of small asymmetric devices delivered by catheters within the vasculature under radiographic guidance are explored for the first time. This new capability for accurate localization will allow the implementation of new devices such as asymmetric, variable porosity stentts for treatment of cerebral aneurysms by modifying aneurysm blood flow characteristics. To optimize the new stentt design, flow reduction in aneurysms needed to induce thrombosis will be explored. Also details of flow and flow modification will be investigated using advanced theoretical and experimental methods. It is expected that this new capability should enable more rapid treatment of aneurysms with less chance of hemorrhage and decreased possibility for recurrence compared with existing procedures and additionally readily enable treatment of wide-necked and giant cerebral aneurysms for the first time.

描述（由申请人提供）： 射线照相可视化的局限性以及缺乏考虑支架展开对血流细节的影响，限制了支架设计为均匀且圆形对称的形式。然而，支架的一些最重要的潜在应用，例如在动脉瘤的治疗中，本质上是不均匀和不对称的。在该项目中，研究了创新型不对称支架的设计及其在新型高分辨率 X 射线图像探测器引导下的部署。特别是，首次探讨了在放射照相引导下定位脉管系统内导管输送的小型不对称装置的旋转方向和纵向距离的局限性和准确性。这种精确定位的新功能将允许实施新设备，例如不对称、可变孔隙率支架，通过改变动脉瘤血流特性来治疗脑动脉瘤。为了优化新支架设计，将探索减少诱导血栓形成所需的动脉瘤流量。还将使用先进的理论和实验方法研究流动和流动修改的细节。预计与现有手术相比，这种新功能将能够更快速地治疗动脉瘤，减少出血机会并降低复发可能性，并且首次能够轻松治疗宽颈和巨大脑动脉瘤。

项目成果

A practical exposure-equivalent metric for instrumentation noise in x-ray imaging systems.

X 射线成像系统中仪器噪声的实用曝光当量度量。

• 发表时间: 2008-09-21
• 影响因子: 3.5
• 作者: Yadava, G K;Kuhls;Rudin, S;Patel, V K;Hoffmann, K R;Bednarek, D R
• 通讯作者: Bednarek, D R

Morphology parameters for intracranial aneurysm rupture risk assessment.

用于颅内动脉瘤破裂风险评估的形态参数。

• 发表时间: 2008-08
• 影响因子: 4.8
• 作者: Dhar, Sujan;Tremmel, Markus;Mocco, J;Kim, Minsuok;Yamamoto, Junichi;Siddiqui, Adnan H;Hopkins, L Nelson;Meng, Hui
• 通讯作者: Meng, Hui

Endovascular image-guided treatment of in-vivo model aneurysms with asymmetric vascular stents (AVS): evaluation with time-density curve angiographic analysis and histology.

使用不对称血管支架（AVS）对体内模型动脉瘤进行血管内图像引导治疗：利用时间密度曲线血管造影分析和组织学进行评估。

• 发表时间: 2008
• 作者: Dohatcu, A;Ionita, C N;Paciorek, A;Bednarek, D R;Hoffmann, K R;Rudin, S
• 通讯作者: Rudin, S

Angiographic imaging evaluation of patient-specific bifurcation-aneurysm phantom treatment with pre-shaped, self-expanding, flow-diverting stents: feasibility study.

使用预成型、自扩张、分流支架治疗患者特异性分叉动脉瘤模型的血管造影成像评估：可行性研究。

• 发表时间: 2011
• 作者: Ionita, Ciprian N;Suri, Himanshu;Nataranjian, Sabareesh;Siddiqui, Adnan;Levy, Elad;Hopkins, Nelson L;Bednarek, Daniel R;Rudin, Stephen
• 通讯作者: Rudin, Stephen

Modification of the NEMA XR21-2000 cardiac phantom for testing of imaging systems used in endovascular image guided interventions.

改进 NEMA XR21-2000 心脏模型，用于测试血管内图像引导干预中使用的成像系统。

• 发表时间: 2009
• 作者: Ionita CN;Dohatcu A;Jain A;Keleshis C;Hoffmann KR;Bednarek DR;Rudin S
• 通讯作者: Rudin S