Assessment of Cognitive Neurodevelopment in Children with Cerebral Palsy in China

中国脑瘫儿童认知神经发育评估

• 批准号: 7963156
• 负责人: PAMELA A MOSES
• 金额: $ 14.71万
• 依托单位: SAN DIEGO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7963156
• 关键词: Address; Adult; Basic Science; Behavioral; Bilateral; Brain; California; Cerebral Palsy; Child; Childhood; China; Chinese People; Cognition; Cognitive; Cognitive deficits; Databases; Development; Diagnosis; Diffusion; Disabled Children; Fiber; Foundations; Future; Goals; Grant; Group Meetings; Growth; Image; Impaired cognition; Impairment; Individual; Interdisciplinary Study; Intervention; Knowledge; Laboratories; Language; Learning; Lesion; Literature; Little' s Disease; Lower Extremity; Magnetic Resonance Imaging; Measures; Mediation; Methods; Modeling; Motor; Neurodevelopmental Disorder; Neuropsychology; Neurosciences Research; Outcome; Pathology; Performance; Perinatal; Pilot Projects; Population; Process; Relative (related person); Research; Research Infrastructure; Resources; Scientist; Series; Site; Spinal; Taiwan; Testing; Time; Training; Universities; Visuospatial; abstracting; base; cognitive neuroscience; design; experience; interdisciplinary collaboration; member; motor deficit; motor disorder; neurodevelopment; patient population; prenatal; relating to nervous system; remediation; white matter

DESCRIPTION (provided by applicant): The goal of this planning grant is to form an interdisciplinary collaboration between scientists at the University of California, San Diego and Beijing Normal University, People's Republic of China (P.R. China) to increase the capacity for the study of neurodevelopmental disorders in P.R. China and advance the basic understanding of the effect that early neural disruption has on cognitive development in children. This grant focuses on the neurodevelopmental disorder of cerebral palsy (CP) in its most common form, spastic diplegia (SDCP). SDCP is a motor disorder of spasticity in the lower limbs that results from prenatal white matter lesions that disrupt cortical-spinal motor fibers. Since SDCP is diagnosed based on motor deficits and has been mainly studied as a motor disorder, relatively little is known about its effects on cognitive and ongoing brain development. CP is internationally prevalent and in P.R. China, which has the world's largest national population, an incident rate of 3.250 presents an urgent problem. At the same time, the scale of the population and high occurrence provides an opportunity to study SDCP as a model of neurodevelopmental pathology and to examine the effects of early and frank disruption of brain growth on cognitive outcome. The specific aims of this grant are to assist in building an infrastructure for neuropsychology and developmental cognitive neuroscience research with pediatric patient populations in P.R. China and to conduct pilot studies to demonstrate the feasibility of assessing cognitive development in children with SDCP in P.R. China. This project studies the profile of cognitive abilities, and their functional and structural neural correlates in a well defined population of children with SDCP. The study focuses on children's visuospatial abilities, shown to be compromised with SDCP, and will examine the underlying functional organization of visuospatial processes. To determine whether or not children's cognitive impairments are specific to visuospatial processing, we will also examine language performance, which has been characterized as being spared with SDCP. The examination of cognitive abilities uses a combination of standardized tests and experimental measures that are specifically designed to probe visuospatial and language abilities. The functional organization of the brain for mediation of visuospatial processes will be examined with functional magnetic resonance imaging (FMRI) and the structural integrity of connective white matter tracts will be assessed with diffusion tensor magnetic resonance imaging. The long-term goal of the project is to lay the foundation for a future R01 grant that will propose interventions that can be tested empirically and are designed to facilitate cognitive development in children with SDCP. The findings from this project will also inform our knowledge of the fundamental principles of brain development and plasticity following early insult using CP as one model of inquiry. PUBLIC HEALTH RELEVANCE: This project aims to increase our understanding of cognitive and brain development in an internationally prevalent neurodevelopmental disorder, spastic diplegia cerebral palsy. Since little is known about the cognitive impairments indicated in this motor disorder, characterizing these deficits is an important first step toward intervention. This project will also inform our knowledge of the general principles of brain development and plasticity following early insult.

描述（由申请人提供）：该规划拨款的目标是在加州大学圣地亚哥分校和中华人民共和国（P.R. China）北京师范大学的科学家之间建立跨学科合作，以提高研究能力中国的神经发育障碍，并促进对早期神经破坏对儿童认知发展影响的基本了解。这笔资助的重点是脑瘫（CP）最常见形式的神经发育障碍，即痉挛性双瘫（SDCP）。 SDCP 是一种下肢痉挛运动障碍，是由产前白质病变破坏皮质脊髓运动纤维引起的。由于 SDCP 是根据运动缺陷来诊断的，并且主要作为运动障碍进行研究，因此对其对认知和持续大脑发育的影响知之甚少。 CP 在国际上很流行，而在拥有世界上最多人口的中国，3.250 的发病率是一个紧迫的问题。与此同时，人口规模和高发生率提供了一个机会来研究 SDCP 作为神经发育病理学模型，并检查早期和直接的大脑生长破坏对认知结果的影响。这笔赠款的具体目的是协助中国儿童患者群体建立神经心理学和发展性认知神经科学研究的基础设施，并进行试点研究以证明评估中国 SDCP 儿童认知发展的可行性。该项目研究了明确定义的 SDCP 儿童群体的认知能力概况及其功能和结构神经相关性。该研究重点关注儿童的视觉空间能力，该能力已被证明受到 SDCP 的影响，并将检查视觉空间过程的潜在功能组织。为了确定儿童的认知障碍是否特定于视觉空间处理，我们还将检查语言表现，而 SDCP 不会影响语言表现。认知能力的检查结合了标准化测试和实验测量，专门用于探测视觉空间和语言能力。将通过功能磁共振成像（FMRI）检查大脑介导视觉空间过程的功能组织，并通过扩散张量磁共振成像评估结缔白质束的结构完整性。该项目的长期目标是为未来的 R01 拨款奠定基础，该拨款将提出可进行实证检验的干预措施，旨在促进 SDCP 儿童的认知发展。该项目的研究结果还将让我们了解早期损伤后大脑发育和可塑性的基本原理，使用 CP 作为一种探究模型。公共健康相关性：该项目旨在增进我们对国际流行的神经发育障碍——痉挛性双瘫脑瘫的认知和大脑发育的了解。由于人们对这种运动障碍所表现的认知障碍知之甚少，因此描述这些缺陷的特征是干预的重要第一步。该项目还将让我们了解早期损伤后大脑发育和可塑性的一般原理。