Buprenorphine for Opioid Dependence in Primary Care

丁丙诺啡在初级保健中治疗阿片类药物依赖

基本信息

批准号：
7798293
负责人：
ERIK W GUNDERSON
金额：
$ 17.5万
依托单位：
UNIVERSITY OF VIRGINIA
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-08-20 至 2010-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7798293
关键词：
Abstinence Agonist Alcohol or Other Drugs use Ambulatory Care Ambulatory Care Facilities Area Attitude Buprenorphine Clinic Clinical Clinical Research Clinical Treatment Clinical Trials Cocaine Cohort Studies Counseling Coupled Data Development Discipline of Nursing Doctor of Medicine Dose Effectiveness Faculty Fellowship Foundations Funding Goals Grant Hamilton Rating Scale for Depression Health Status Individual Internist Label Maintenance Medical Medical Education Medical Societies Medicine Mentored Clinical Scientist Award Mentors Methadone Methods Opiate Addiction Opioid Outcome Patient Transfer Patients Pharmaceutical Preparations Physicians Pilot Projects Primary Care Physician Primary Health Care Principal Investigator Procedures Psychiatry Public Health Qualifying Randomized Controlled Clinical Trials Recruitment Activity Research Research Design Research Personnel Research Training SF-36 Self Efficacy Specialist Structure Substance abuse problem Surveys Symptoms Testing Therapeutic Uses Time Training Treatment Effectiveness Treatment Efficacy Universities Week Work addiction base career cohort compare effectiveness day design experience follow-up functional status improved innovation medical specialties novel professor programs psychosocial skills social treatment program treatment trial

项目摘要

DESCRIPTION (provided by applicant): Office-based buprenorphine treatment promises to expand treatment access for opioid dependent individuals. Yet physicians have been reluctant to begin prescribing the medication, indicating a compelling need to develop innovative strategies to train physicians and integrate buprenorphine treatment into medical practice. The goal of this mentored clinical scientist award is to enhance the developing clinical research skills of Erik Gunderson, M.D. through research on integrating buprenorphine treatment of opioid dependence in primary care. After completing a substance abuse fellowship, Dr. Gunderson joined the faculty in the Division as an Assistant Clinical Professor of Medicine in Psychiatry, working both in a primary care clinic and at a specialty buprenorphine treatment program. His pilot data on integrated opioid dependence treatment provide preliminary support for the feasibility and effectiveness of buprenorphine in primary care. Dr. Gunderson has received funding through a pilot study program of the Division's NIDA-funded center grant and an private foundation to study medical education on substance abuse. However, to become an independent clinical researcher, he will need formal course work, mentoring, and release of time from his extensive clinical and administrative responsibilities. During the next several years, Dr. Gunderson plans to conduct mentored formative research and a clinical trial on integrated buprenorphine treatment in primary care versus a specialty clinic setting. This research and additional training will prepare him to meet his long term research career goal of improving and expanding treatment of substance abuse in primary care. Under the sponsorship and guidance of Dr. Frances Levin, together with other faculty, Dr. Gunderson's training plan combines formal course work with clinical research experience. He will work closely with preceptors to receive training in the following areas: methods of integrating opioid dependence treatment into primary care, clinical treatment trial study design and interpretation, and biostatisties. Specifically, his research plan includes a demonstration project to determine the feasibility and effectiveness of buprenorphine maintenance delivered by general internists in a primary care clinic. Findings from this project will be used to inform development of a randomized trial of the effectiveness of buprenorphine maintenance delivered in primary care versus a specialty clinic. The combined mentoring, training and research plan will provide Dr. Gunderson with unique training enabling him to develop an independent research career focused on integrating substance abuse treatment in primary care.

描述（由申请人提供）：基于办公室的丁丙诺啡治疗有望扩大阿片类药物依赖者的治疗机会。然而，医生们一直不愿意开始开这种药物，这表明迫切需要制定创新策略来培训医生并将丁丙诺啡治疗纳入医疗实践。该临床科学家指导奖的目标是通过在初级保健中整合丁丙诺啡治疗阿片类药物依赖的研究，提高医学博士 Erik Gunderson 的临床研究技能。完成药物滥用奖学金后，冈德森博士加入该部门，担任精神病学医学助理临床教授，在初级保健诊所和专业丁丙诺啡治疗项目工作。他关于综合阿片类药物依赖治疗的试点数据为丁丙诺啡在初级保健中的可行性和有效性提供了初步支持。 Gunderson 博士通过该部门 NIDA 资助的中心赠款和一个私人基金会的试点研究计划获得了资金，用于研究药物滥用方面的医学教育。然而，要成为一名独立的临床研究员，他需要正式的课程作业、指导，并从广泛的临床和行政职责中腾出时间。在接下来的几年中，Gunderson 博士计划在初级保健与专科诊所环境中开展有关丁丙诺啡综合治疗的指导形成性研究和临床试验。这项研究和额外的培训将使他做好准备，以实现他的长期研究职业目标，即改善和扩大初级保健中药物滥用的治疗。在 Frances Levin 博士和其他教师的赞助和指导下，Gunderson 博士的培训计划将正式课程工作与临床研究经验结合起来。他将与导师密切合作，接受以下领域的培训：将阿片类药物依赖治疗纳入初级保健的方法、临床治疗试验研究设计和解释以及生物统计学。具体来说，他的研究计划包括一个示范项目，以确定普通内科医生在初级保健诊所提供丁丙诺啡维持治疗的可行性和有效性。该项目的研究结果将用于指导一项随机试验的开展，该试验旨在比较初级保健与专科诊所提供的丁丙诺啡维持治疗的有效性。指导、培训和研究相结合的计划将为冈德森博士提供独特的培训，使他能够发展独立的研究生涯，专注于将药物滥用治疗纳入初级保健。