Kidney Disease in HIV-Hepatitis C Virus Co-Infection

HIV-丙型肝炎病毒合并感染中的肾脏疾病

• 批准号: 7409719
• 负责人: CHRISTINA M WYATT
• 金额: $ 12.92万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7409719
• 关键词: Acute; Affect; Americas; Black race; Cardiac; Chronic Disease; Chronic Kidney Failure; Clinical; Cohort Studies; Communicable Diseases; Complication; Development; Diagnosis; Early Diagnosis; Epidemiology; Family history of; Foundations; Future; Guidelines; HIV; HIV Infections; Hepatic; Hepatitis C; Hepatitis C virus; High Prevalence; Incidence; Infection; Integration Host Factors; Kidney Diseases; Kidney Failure; Liver; Liver diseases; Minority; Monitor; Morbidity - disease rate; Pathogenesis; Patients; Population; Prevalence; Publishing; Research Personnel; Risk; Risk Factors; Screening procedure; Societies; Testing; Translational Research; Viral; Virus; Virus Diseases; antiretroviral therapy; base; cohort; kidney epithelial cell; mortality; programs; prospective

DESCRIPTION (provided by applicant): With the widespread introduction of antiretroviral therapy, HIV has become a chronic disease, and HIV- related kidney disease has emerged as an important cause of morbidity and mortality. Both HIV infection and antiretroviral therapy have been associated with kidney disease. Studies suggest that the risk of HIV-related kidney disease is increased in patients with HIV-Hepatitis C virus co-infection, but studies have not focused on the epidemiology of kidney disease in these patients. Worldwide, an estimated 40 million people are infected with HIV, and 4-5 million people are co-infected with HIV and Hepatitis C. The highest prevalence of HIV-Hepatitis C co-infection occurs in minority populations at increased risk for kidney disease. This proposal aims to investigate the epidemiology of kidney disease in patients with HIV-Hepatitis C co-infection, and to identify host and viral factors associated with increased risk. The identification of risk factors will identify patients who may benefit from enhanced screening for early detection and treatment of kidney disease. The primary objective of this application is to support the candidate's development as an independent clinical and translational investigator in the field of HIV-related kidney disease. The specific aims of this proposal are: (1) To compare the epidemiology of kidney disease in patients with HIV-Hepatitis C co-infection to that in patients with either HIV or Hepatitis C virus alone. (2) To identify host factors associated with kidney disease in patients with HIV-Hepatitis C co-infection. (3) To identify viral factors associated with kidney disease in patients with HIV-Hepatitis C co-infection. Relevance: HIV affects more than 40 million people worldwide, and kidney disease is an important complication in patients being treated for HIV. Minority patients with both HIV and Hepatitis C virus infection may be at particularly high risk for kidney disease. This study will help to identify HIV-infected patients who may be at risk for kidney disease, in order to diagnose and treat kidney disease before the development of kidney failure and other serious complications.

描述（由申请人提供）： 随着抗逆转录病毒疗法的广泛引入，HIV已成为一种慢性疾病，与HIV相关的肾脏疾病已成为发病率和死亡率的重要原因。 HIV感染和抗逆转录病毒疗法都​​与肾脏疾病有关。研究表明，HIV-肝炎病毒感染患者患HIV相关的肾脏疾病的风险增加，但研究并未集中在这些患者的肾脏疾病的流行病学上。在全球范围内，估计有4000万人感染了艾滋病毒，4-5万人与艾滋病毒和肝炎共同感染了HIV和肝炎。少数族裔人口中，HIV - 肝炎共同感染的最高患病率是增加肾脏疾病风险。该提案旨在研究HIV-Hepatitis C共感染患者肾脏疾病的流行病学，并确定与风险增加有关的宿主和病毒因素。识别危险因素将确定可能从增强筛查中受益于肾脏疾病的早期发现和治疗的患者。该应用的主要目的是支持候选人作为与HIV相关肾脏疾病领域的独立临床和转化研究者的发展。 该提案的具体目的是： （1）比较HIV-肝炎共同感染患者的肾脏疾病的流行病学与仅HIV或乙型肝炎病毒的患者中的患者。 （2）确定HIV - 肝炎共同感染患者中与肾脏疾病有关的宿主因素。 （3）确定HIV - 肝炎共同感染患者中与肾脏疾病有关的病毒因素。 相关性：艾滋病毒影响全球超过4000万人，肾脏疾病是接受艾滋病毒治疗的患者的重要并发症。艾滋病毒和丙型肝炎病毒感染的少数族裔患者可能患肾脏疾病的风险特别高。这项研究将有助于确定可能有肾脏疾病风险的HIV感染患者，以便在肾衰竭和其他严重并发症发生之前诊断和治疗肾脏疾病。