Training in Radiation Oncology Translational Research

放射肿瘤学转化研究培训

• 批准号: 7486811
• 负责人: ROSS B MIKKELSEN
• 金额: $ 20.16万
• 依托单位: VIRGINIA COMMONWEALTH UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7486811
• 关键词: Radiation Oncology; Training; Translational Research

DESCRIPTION (provided by applicant): This program supports research training at the pre-doctoral and post-doctoral levels in radiation biology, medical physics and imaging relevant to radiation oncology. The program (1 predoctoral, 4 postdoctoral students) consists of 3 years support for post-doctoral students and 2-3 years for graduate students (the first 2 years are covered by the University). Pre-doctoral candidates are selected from interested MD/PHD students and graduate students in the VCU Medical Physics PHD program. Post-doctoral candidates are recruited from Radiation Oncology and Radiology residents with an interest in translational research and from individuals identified by normal recruitment mechanisms with interests in radiation biology and physics as applied to radiation oncology. There are 11 faculty preceptors with NIH funding in medical physics, imaging and cellular biology. Students are introduced to general aspects of cancer and radiation biology through lecture series and in formal courses offered in the Department, the basic science departments and at the NCI designated Massey Cancer Center. Students take a course in scientific ethics. Training in radiological physics includes formal courses in dosimetry, diagnostic imaging and instrumentation, and mentored research in intensity modulated radiotherapy, brachytherapy and diagnostic imaging. For biology students, mentored research in modern radiobiology includes DNA repair mechanisms, radiation-induced signal transduction mechanisms, and reactive oxygen/nitrogen biology. An emphasis in training is on the translational aspects of their research and this is accomplished through the strong translational research program in the Department of Radiation Oncology at VCU including Phase I gene therapy trials and courses in biostatistics focused on clinical and animal trials. The NIH-funded medical physics grants are translational in nature. The Department's Program Project Grant emphasizes modern molecular biological approaches to identifying targets for radiosensitization and validating these targets in vivo in animal studies. Bringing the results from research to applications in the clinic ("bench to bedside") is a major goal of the National Cancer Institute. To achieve this goal requires that the scientists and physicians alike are adequately trained in translational research. The purpose of this program is to provide research training in radiation oncology with an emphasis on the translational aspects for both physician and scientist.

描述（由申请人提供）：该计划支持与放射肿瘤学相关的放射生物学、医学物理和成像方面的博士前和博士后水平的研究培训。该项目（1名博士前学生，4名博士后学生）包括为博士后学生提供3年的支持，为研究生提供2-3年的支持（前2年由大学承担）。博士前候选人是从感兴趣的弗吉尼亚联邦大学医学物理博士项目的医学博士/博士生和研究生中选拔出来的。博士后候选人是从对转化研究感兴趣的放射肿瘤学和放射学住院医师中招募的，也从通过正常招聘机制确定的对放射肿瘤学应用的放射生物学和物理学感兴趣的个人中招募的。医学物理、成像和细胞生物学领域有 11 名教师导师获得 NIH 资助。通过系列讲座以及该系、基础科学系和 NCI 指定的梅西癌症中心提供的正式课程，向学生介绍癌症和放射生物学的一般知识。学生学习科学伦理课程。放射物理学培训包括剂量测定、诊断成像和仪器方面的正式课程，以及调强放射治疗、近距离放射治疗和诊断成像方面的指导研究。对于生物学专业的学生来说，现代放射生物学的指导研究包括DNA修复机制、辐射诱导的信号转导机制和活性氧/氮生物学。培训的重点是他们研究的转化方面，这是通过弗吉尼亚联邦大学放射肿瘤学系强大的转化研究项目来完成的，包括 I 期基因治疗试验以及专注于临床和动物试验的生物统计学课程。美国国立卫生研究院资助的医学物理补助金本质上是转化性的。该部门的计划项目拨款强调现代分子生物学方法来确定放射增敏目标并在动物研究中在体内验证这些目标。将研究结果应用于临床（“实验室到床边”）是国家癌症研究所的主要目标。为了实现这一目标，科学家和医生都需要接受转化研究方面的充分培训。该计划的目的是提供放射肿瘤学研究培训，重点是医生和科学家的转化方面。