Predicting Transitions Among Community-Dwelling Elders

预测社区老年人的转变

• 批准号: 7212095
• 负责人: ILENE HARRIS
• 金额: $ 12.93万
• 依托单位: UNIVERSITY OF MARYLAND BALTIMORE
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7212095
• 关键词: Address; Affect; Aging; Area; Behavior; Behavioral; Clinical; Communities; Complement; Data; Data Analyses; Data Sources; Databases; Disease; Drug usage; Elderly; Environment; Epidemiology; Event; Gerontology; Goals; Health Services Research; Health Status; Incidence; Independent Living; Intervention; Lead; Learning; Life; Literature; Long-Term Care; Medicare; Mentored Research Scientist Development Award; Mentors; Nursing Homes; Pharmaceutical Preparations; Pharmacotherapy; Prevalence; Publishing; Qualitative Methods; Qualitative Research; Research; Research Training; Resources; Risk; Risk Factors; Safety; Screening procedure; Surveys; Testing; Training; Work; base; beneficiary; community living; computing resources; design; experience; improved; instrument; interest; member; predictive modeling; skills

DESCRIPTION (provided by applicant): This application is a request for a Mentored Research Scientist Development Award (K01) to further Dr. Ilene Zuckerman's research in the area of epidemiology of aging and long-term care, with a focus on medication-related issues. Adverse drug events are risk factors for elders transitioning from independent community living to dependent environments such as nursing homes. Medication-related behaviors that lead to adverse drug events and subsequent transitions are preventable with effective intervention. Screening for transitions can identify high-risk elders for interventions to avoid preventable transitions. Dr. Zuckerman's goal for this application is to build a research agenda that examines factors associated with transitions in the elderly. The central hypothesis is that socio-demographic, clinical, behavioral and medication use factors can discriminate elders who experience transitions from independent to dependent settings from those who do not. The objective of the proposed research will be accomplished by pursuing three specific aims: 1) estimate the association between transitions from independent to dependent living and medication use factors in the elderly; 2) develop a predictive model for transitioning from independent to dependent living; and 3) develop and pilot test a screening instrument, based on the predictive model, to discriminate older adults who will experience a transition from those who will not. To accomplish the first two aims, multivariable analysis of survey and administrative claims data will be performed. Qualitative methods will be used to develop and pilot test the screening instrument in Aim #3. In addition to experience gained from completing the proposed research, Dr. Zuckerman will engage in learning activities to enhance her quantitative and qualitative research skills. The proposed training and research are based on her professional interests and build on current work and previous experience. The project represents her continuing efforts to improve the safety of drug use for older adults by understanding the association between drug use factors and elder transitions from independent to dependent environments. Dr. Zuckerman is particularly well prepared to undertake this proposed research, with clinical experience in geriatric pharmacotherapy and epidemiological training. In addition, the mentor and co-mentors have extensive epidemiology of aging research expertise. This research is significant in that it bridges the disparate literature that has separately examined medication use factors and transitions. It is an incremental and important step to building a research agenda that examines socio-demographic, clinical and behavioral factors that affect medication use and transitions in the elderly. Thus, the findings will allow Dr. Zuckerman to build a research agenda that addresses her long term goal to reduce the incidence and prevalence of preventable adverse drug events in the elderly, and to design and evaluate interventions that are targeted toward preventable risk factors for transitions.

描述（由申请人提供）：本申请是授予指导研究科学家发展奖（K01）的请求，以进一步进一步iLene Zuckerman博士在衰老和长期护理流行病学领域的研究，重点介绍与药物有关的问题。不利的毒品事件是长者从独立社区生活到养老院等依赖环境的风险因素。通过有效干预，可以预防导致药物不良事件和随后过渡的与药物相关的行为。筛查过渡可以识别高风险长者进行干预措施，以避免可预防的过渡。 Zuckerman博士实现此应用的目标是建立一个研究议程，研究与老年人过渡相关的因素。中心假设是，社会人口统计学，临床，行为和药物使用因素可以区分长者，这些长者经历了从独立的环境到与没有人的依赖环境的过渡。拟议研究的目的将通过追求三个具体目标来实现：1）估计从独立生活到依赖的生活与 老年人使用药物使用因素； 2）开发一个从独立生活过渡到依赖生活的预测模型； 3）基于预测模型开发和试点测试筛选工具，以区分将经历不将不会过渡的老年人。为了实现前两个目标，将对调查和行政索赔数据进行多变量分析。定性方法将用于开发和试点AIM＃3中的筛选工具。除了完成拟议的研究中获得的经验外，扎克曼博士还将从事学习活动，以增强其定量和定性研究技能。拟议的培训和研究是基于她的专业利益，并以当前的工作和以前的经验为基础。该项目代表了她不断的努力，以通过了解吸毒因素与从独立环境到依赖环境的老年人过渡之间的关联，以提高老年人的吸毒安全性。 Zuckerman博士特别准备接受 这项提出的研究，具有老年药物治疗和流行病学培训方面的临床经验。此外，指导者和联合给予者还具有广泛的衰老研究专业知识流行病学。这项研究很重要，因为它桥接了分开检查药物使用因素和过渡的不同文献。这是建立研究议程的增量和重要步骤，该研究议程研究了影响老年人用药和过渡的社会人口统计学，临床和行为因素。因此，这些发现将使Zuckerman博士能够建立研究议程，以探讨她的长期目标，以减少老年人中可预防的不良药物事件的发生率和流行，并设计和评估针对可预防过渡风险因素的干预措施。