THE CNS AND HEART FAILURE

中枢神经系统和心力衰竭

• 批准号: 7171048
• 负责人: EVELYN Heymann SCHLENKER
• 金额: $ 0.7万
• 依托单位: UNIVERSITY OF SOUTH DAKOTA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171048
• 关键词: heart failure; pathologic process

DESCRIPTION (provided by applicant): This proposal is to establish a Center of Biomedical Research Excellence; (COBRE) on "Mechanisms of Cardiovascular Remodeling". Cardiovascular diseases account for nearly half of all deaths in the US. In recent years, it has become widely recognized that pathological remodeling of the cardiovascular system may not be simply a consequence of hemodynamic derangements but may play a primary role in the disease process. Therapeutic interventions that prevent or reverse remodeling in the head, blood vessels, and kidneys clearly lead to a reduction in mortality and improvement in quality of life. The associated neurohumoral and molecular/signaling mechanisms are poor y understood. Realizing the enormous therapeutic implications of discoveries in this field, the University of South Dakota School of Medicine has made a conscious effort to assemble a team of investigators to focus on work in cardiovascular remodeling. Four promising new faculty with research interests in this area have been recruited recently. Each have trained with world-renowned investigators. The COBRE Director is an internationally recognized expert in cardiovascular remodeling. Two other NIH funded faculty with cardiovascular expertise will provide additional mentoring and technical assistance. Cumulatively, the group has expertise in physiology, pharmacology, morphology, molecular biology, signal transduction, transgenesis, genomics, and proteomics. COBRE funding will facilitate our promising junior scientists in developing productive. NIH-funded research programs and will add depth and additional expertise to the croup. We believe the end result will be an internationally recognized research program that makes substantial contributions to the field. The COBRE contains four projects and four cores (including administration). Project 1, led by Dr. Xuejun Wang, will define the pathogenic role of the ubiquitin-proteasome system in cardiac remodeling in failure. Project 2, led by Dr. Faqian Li, will test the role of a key signaling pathway in cell growth leading to chamber dilatation in heart failure. Project 3, led by Dr. Rachid Kacimi, will examine the role of newly discovered cytokines in ischemic heart failure.

描述（由申请人提供）：该提案旨在建立一个生物医学研究卓越中心； （COBRE）关于“心血管重塑的机制”。心血管疾病占美国所有死亡人数的近一半。近年来，人们广泛认识到心血管系统的病理重塑可能不仅仅是血流动力学紊乱的结果，而且可能在疾病过程中发挥主要作用。预防或逆转头部、血管和肾脏重塑的治疗干预措施显然可以降低死亡率并改善生活质量。相关的神经体液和分子/信号传导机制尚不清楚。南达科他大学医学院意识到这一领域的发现具有巨大的治疗意义，因此有意识地组建了一个研究小组，专注于心血管重塑的工作。最近招募了四名对该领域有研究兴趣的有前途的新教师。每个人都接受过世界知名调查员的培训。 COBRE 主任是国际公认的心血管重塑专家。 NIH 资助的另外两名具有心血管专业知识的教师将提供额外的指导和技术援助。总的来说，该小组在生理学、药理学、形态学、分子生物学、信号转导、转基因、基因组学和蛋白质组学方面拥有专业知识。 COBRE 资金将促进我们有前途的初级科学家发展生产力。美国国立卫生研究院 (NIH) 资助的研究项目将为该小组增加深度和额外的专业知识。我们相信最终的结果将是一个国际认可的研究项目，为该领域做出重大贡献。 COBRE 包含四个项目和四个核心（包括管理）。项目1由王学军博士领导，将明确泛素-蛋白酶体系统在衰竭心脏重塑中的致病作用。项目2由李法前博士领导，将测试细胞生长导致心力衰竭心室扩张的关键信号通路的作用。项目 3 由 Rachid Kacimi 博士领导，将研究新发现的细胞因子在缺血性心力衰竭中的作用。