Stress Reactivity in Insomnia

失眠的应激反应

基本信息

批准号：
7472241
负责人：
Philip Richard Gehrman
金额：
$ 15.23万
依托单位：
UNIVERSITY OF THE SCIENCES PHILADELPHIA
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-04-01 至 2008-08-16
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7472241
关键词：
Address Adult Affect Age American Basic Science Beds CRH gene Chronic Insomnia Collection Condition Corticotropin-Releasing Hormone Data Development Disruption Electroencephalography Etiology Eye Frequencies Functional disorder Future Gender Goals HPSE gene Heart Rate Human Hydrocortisone Individual Instruction Laboratories Lead Link Measures Mediator of activation protein Methods Nature Nervous System Physiology Neurobiology Numbers Outcome Outcome Measure Patient Self-Report Patients Physiological Play Population Positioning Attribute Prevention Primary Insomnia Procedures Process Public Health Rate Relative (related person)Research Research Personnel Role Saliva Salivary Sampling Shock Sleep Sleep Disorders Sleeplessness Stress Sympathetic Nervous System System Time Wrist Yohimbine alpha-amylase biological adaptation to stress experience falls hypothalamic-pituitary-adrenal axis improved indexing innovation interest neurobiological mechanism novel programs psychological stressor response sleep regulation stressor

Address Adult Affect Age American Basic Science Beds CRH gene Chronic Insomnia Collection Condition Corticotropin-Releasing Hormone Data Development Disruption Electroencephalography Etiology Eye Frequencies Functional disorder Future Gender Goals HPSE gene Heart Rate Human Hydrocortisone Individual Instruction Laboratories Lead Link Measures Mediator of activation protein Methods Nature Nervous System Physiology Neurobiology Numbers Outcome Outcome Measure Patient Self-Report Patients Physiological Play Population Positioning Attribute Prevention Primary Insomnia Procedures Process Public Health Rate Relative (related person)Research Research Personnel Role Saliva Salivary Sampling Shock Sleep Sleep Disorders Sleeplessness Stress Sympathetic Nervous System System Time Wrist Yohimbine alpha-amylase biological adaptation to stress experience falls hypothalamic-pituitary-adrenal axis improved indexing innovation interest neurobiological mechanism novel programs psychological stressor response sleep regulation stressor

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项目摘要

Insomnia is the most prevalent sleep disorder, affecting 6-10% of the U.S. population, and is associated with a number of daytime sequelae. However, little is known about the underlying neurobiological mechanisms that might lead to insomnia. There is preliminary evidence that the stress system may play a major role in the etiology of insomnia. The goal of the present study is to examine whether individuals with insomnia are more reactive to stress than healthy sleepers. We hypothesize that insomniacs will show heightened reactivity to the anticipation of a stressor. The proposed project will include 20 individuals with primary insomnia and 20 age- and gender-matched healthy sleeping controls. After collection of background measures and an adaptation night in the sleep laboratory, subjects will undergo a baseline and stress night. At 30 minutes before their habitual bedtime, upon awakening in the morning, and 30 minutes after waking up, subjects will provide a saliva sample and complete ratings of their current level of stress. On the adaptation and baseline nights no additional procedures will take place. On the stress night a mild electric shock will be administered to the subject after it is first demonstrated on the research personnel. They will then be told that they may receive up to 3 additional electric shocks during the night, although they will not actually receive any more shocks. The primary outcome measure is reactivity of sleep latency on the stress night compared to the baseline night. Secondary outcome measures are: subjective ratings of stress, salivary cortisol and alpha-amylase, sleep quantity and quality, high frequency EEG power, and heart rate variability. The results of this study will begin to determine whether the stress system plays a role in the neurobiology of insomnia. Increasing our understanding of the etiology of insomnia may improve prevention and treatment of the condition and reduce the large public health burden of insomnia.

失眠是最普遍的睡眠障碍，影响美国6-10％人口，与白天后遗症有关。但是，很少知道可能导致的基本神经生物学机制失眠。有初步证据表明，压力系统可能会发挥作用在失眠的病因中的作用。本研究的目的是检查失眠的个体是否比健康更具压力反应卧铺。我们假设失眠症会显示出对期待压力源。拟议的项目将包括20名主要失眠和 20岁和性别匹配的健康睡眠控制。收集后背景测量和睡眠实验室的适应之夜，受试者将经历基线和压力之夜。习惯前30分钟睡前，早上醒来，醒来30分钟后，受试者将提供唾液样本和目前的完整评级压力。在改编和基线之夜，不会采取其他程序地方。在压力之夜在研究人员首次证明它之后。然后他们会告诉他们晚上可能会收到多达3次额外的电击，尽管他们实际上不会再收到更多的震动。主要结果与与之相比基线之夜。次要结果指标是：压力的主观评分，唾液皮质醇和α-淀粉酶，睡眠数量和质量，高频脑电图和心率变异性。这项研究的结果将开始确定压力系统是否在失眠的神经生物学中起作用。提高我们对失眠的病因可能会改善病情的预防和治疗减轻失眠的巨大公共卫生负担。