Antiretroviral Therapy for HIV-2 Infection in Senegal

塞内加尔针对 HIV-2 感染的抗逆转录病毒治疗

• 批准号: 7367162
• 负责人: Geoffrey Scott Gottlieb
• 金额: $ 62.92万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-07 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7367162
• 关键词: Acquired Immunodeficiency Syndrome; Adverse effects; Anti-Retroviral Agents; Arts; Blood; CD3 Antigens; CD4 Positive T Lymphocytes; CD4/CD8 ratio procedure; CD8B1 gene; Cell Count; Cessation of life; Characteristics; Clinical; Control Groups; Cultured Cells; Drug resistance; Drug-sensitive; Event; Evolution; Failure; Gagging; Goals; Growth; HIV-1; HIV-1 drug resistance; HIV-2; Immunologics; Individual; Infection; Mediating; Methods; Mutation; NNRTI-resistance; Natural History; Outcome; Pattern; Peripheral Blood Mononuclear Cell; Phenotype; Phylogenetic Analysis; Plasma; Play; Population; Protease Gene; RNA; RNA-Directed DNA Polymerase; Rate; Resistance; Resources; Role; Senegal; Sexual Transmission; Staging; Symptoms; T-Lymphocyte Subsets; Testing; Time; Treatment Protocols; Vertical Disease Transmission; Viral; Viral Load result; Virus; antiretroviral therapy; cohort; drug resistant virus; env Genes; fitness; mortality; programs; prospective; response; trend; viral DNA

DESCRIPTION (provided by applicant): The overarching goals of this proposal are to further our understanding of the effect of potent antiretroviral therapy (ART) on Human Immunodeficiency Virus Type 2 (HIV-2) infection. HIV-2 is generally less pathogenic than HIV-1. Compared to HIV-1, HIV-2 infection is characterized by a much longer asymptomatic stage, lower plasma viral loads, slower decline in CD4+ T cell count, decreased mortality rate due to AIDS, lower rates of mother to child transmission, and lower rates of sexual transmission. Nonetheless, a significant proportion of HIV-2 infected individuals eventually progress to AIDS. Antiretrov'iral therapy is becoming increasingly available in resource-limited settings. In Senegal where both HIV-1 and HIV-2 are found, a national program of providing antiretroviral treatment (ART) for those with AIDS, CD4+ T cell counts less than 200/mm3, or CD4+ T cell counts less than 350/mm3 and clinical symptoms has been established. However, the effects of ART on outcome, immunologic response, viral load, dynamics and evolution, HIV-2 drug resistance and fitness in HIV-2 infected individuals are largely unknown. Our longstanding longitudinal cohort of HIV-2 infected subjects from Dakar, Senegal provides a unique opportunity to study the role ART plays in suppressing HIV-2 infection. The Specific Aims of this proposal are: AIM 1: To determine the clinical, virologic and immunologic outcomes associated with antiretroviral therapy (ART) in a longitudinal prospective HIV-2 infected Senegalese cohort. AIM 2: To assess role of drug resistance in viruses that emerge in HIV-2 infected subjects with virologic failure and to determine if there are qualitative and quantitative differences the drug resistant viruses that emerge between HIV-2 and HIV-1.

描述（由申请人提供）：该提案的总体目标是进一步了解有效的抗逆转录病毒疗法 (ART) 对人类免疫缺陷病毒 2 型 (HIV-2) 感染的影响。 HIV-2 的致病性通常低于 HIV-1。与HIV-1相比，HIV-2感染的特点是无症状期更长、血浆病毒载量更低、CD4+T细胞计数下降更慢、艾滋病死亡率降低、母婴传播率更低、传播率更低。性传播。尽管如此，相当一部分 HIV-2 感染者最终会发展为艾滋病。在资源有限的环境中，抗逆转录病毒治疗变得越来越可用。在同时发现 HIV-1 和 HIV-2 的塞内加尔，一项为艾滋病患者提供抗逆转录病毒治疗 (ART) 的国家计划，其中 CD4+ T 细胞计数低于 200/mm3，或 CD4+ T 细胞计数低于 350/mm3，并且临床症状已确定。 然而，ART 对 HIV-2 感染者的结果、免疫反应、病毒载量、动力学和进化、HIV-2 耐药性和健康状况的影响在很大程度上尚不清楚。我们对来自塞内加尔达喀尔的 HIV-2 感染受试者进行长期纵向队列研究，为研究 ART 在抑制 HIV-2 感染中的作用提供了独特的机会。该提案的具体目标是： 目标 1：在纵向前瞻性 HIV-2 感染塞内加尔队列中确定与抗逆转录病毒治疗 (ART) 相关的临床、病毒学和免疫学结果。目标 2：评估病毒学失败的 HIV-2 感染受试者中出现的病毒耐药性的作用，并确定 HIV-2 和 HIV-1 之间出现的耐药病毒是否存在定性和定量差异。