Infection, Inflammation and Preeclampsia

感染、炎症和先兆子痫

基本信息

批准号：
7455919
负责人：
CATHERINE L HAGGERTY
金额：
$ 58.84万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-07-01 至 2010-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7455919
关键词：
Affect Age Antibodies Aspirin Behavioral Birth C-reactive protein Chlamydophila pneumoniae Clinical Cohort Studies Condition Cytomegalovirus Cytomegalovirus Infections Disease Functional disorder Genetic Polymorphism Growth Factor Herpesvirus 1 High Risk Woman Human Herpesvirus 2 Immunoglobulin G Immunoglobulin M Infection Infectious Agent Inflammation Inflammatory Inflammatory Response Injury Investigation Link Measures Mediating Mediator of activation protein Morbidity - disease rate Nested Case-Control Study Perinatal Play Pre-Eclampsia Pregnancy Pregnant Women Prevalence Prevention Process Production Prospective Studies Public Health Recurrence Risk Role Sampling Score Screening procedure Serological Serum Simplexvirus Testing Thinking Vaccination Visit Woman antioxidant therapy base case control cohort cytokine human disease improved insight interest postnatal prenatal prenatal exposure prospective reproductive tool

项目摘要

DESCRIPTION (provided by applicant): Preeclampsia is a disease of human pregnancy that causes considerable maternal and perinatal morbidity. Endothelial injury and dysfunction are thought to occur early in the disease process, and may relate to an excessive intravascular maternal inflammatory response. Primary infections and polymorphisms associated with upregulated cytokine production are known to trigger such an inflammatory response. Furthermore, infectious agents and cytokines may invoke endothelial activation through induction of maternal inflammatory mediators and growth factors. We propose parallel case-control investigations, nested within the Collaborative Perinatal Project (n = 55,908) and the Danish National Birth Cohort (n = 101,046). Using stored first prenatal visit and postnatal serum samples, we propose to: 1) determine the relationship between maternal primary infection with Herpes Simplex Virus (HSV)-1, HSV-2, Cytomegalovirus (CMV), Chlamydia Pneumoniae (CP) and the risk of preeclampsia; 2) examine the relationship between early pregnancy cytokines, CRP and preeclampsia; 3) investigate multiple factors affecting infection status and its relation to preeclampsia; and 4) investigate cytokine clusters and determine their associations with preeclampsia. The notion that infection and inflammation may trigger preeclampsia would provide insight into the pathophysiology of this condition. Further, it would suggest public health measures, such as universal HSV and CP screening, treatment, and vaccination among women of reproductive age, or aspirin and antioxidant therapy among high risk women. Finally, cytokine and CRP testing may prove to be effective tools for identifying women at risk for developing preeclampsia.

描述（由申请人提供）：先兆子痫是人类妊娠的一种疾病，会导致大量产妇和围产期发病率。内皮损伤和功能障碍被认为是在疾病过程的早期发生，并且可能与血管内孕产妇炎症反应过度有关。已知与上调的细胞因子产生相关的原发性感染和多态性会引发这种炎症反应。此外，传染性剂和细胞因子可能通过诱导母体炎症介质和生长因子而引起内皮激活。我们提出了平行的病例对照调查，该调查嵌套在协作围产期项目中（n = 55,908）和丹麦国家出生队列（n = 101,046）。使用存储的首次产前访问和产后血清样品，我们建议：1）确定母体原发性感染与疱疹单纯疱疹病毒（HSV）-1，HSV-2，HSV-2，巨细胞病毒（CMV），衣原体肺炎（CP）（CP）（CP）（CP）（CP）（CP）（CP）（CP）（CP）和风险。 2）检查早期妊娠细胞因子，CRP和先兆子痫之间的关系； 3）研究影响感染状况的多个因素及其与先兆子痫的关系； 4）研究细胞因子簇并确定其与先兆子痫的关联。感染和炎症可能会引发子痫前期的观念将提供对这种疾病的病理生理学的见解。此外，这将建议在高风险妇女中的生殖年龄妇女或阿司匹林和阿司匹林和抗氧化剂治疗中的普遍HSV和CP筛查，治疗和疫苗接种等公共卫生措施。最后，细胞因子和CRP测试可能被证明是识别患有前启动前的妇女的有效工具。