Improved MR Techniques for Coronary Artery Imaging

改进的冠状动脉成像 MR 技术

基本信息

批准号：
7232292
负责人：
CRAIG H MEYER
金额：
$ 35.73万
依托单位：
UNIVERSITY OF VIRGINIA
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-07-01 至 2011-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7232292
关键词：
Angiography Arterial Fatty Streak Arteries Biomedical Engineering Blood Cardiac Caring Cause of Death Chest Pain Clinical Clinical Engineering Clinical Investigator Clinical Research Collaborations Comparative Study Coronary Coronary Angiography Coronary Arteriosclerosis Coronary artery Correlative Study Detection Development Diagnosis Diagnostic Imaging Disease regression Elements Equilibrium Feedback Goals Heart Heart Diseases Image Imaging Techniques Invasive Length Lesion Magnetic Resonance Magnetic Resonance Angiography Magnetic Resonance Imaging Methods Morphologic artifacts Motion Myocardial Infarction Noise Numbers Patients Phase Physiologic pulse Positioning Attribute Predisposition Preparation Pulse taking Reading Research Project Grants Resolution Risk Scanning Signal Transduction Techniques Testing Time Training Ultrasonography United States density design heart imaging image reconstruction improved men novel novel diagnostics performance tests programs response success tool

项目摘要

DESCRIPTION (provided by applicant): The goal of this research project is to develop and evaluate a set of new techniques for noninvasive coronary artery imaging using magnetic resonance imaging (MRI). Because coronary artery disease remains the major cause of death in the United States, a noninvasive method for coronary artery imaging providing accurate detection and quantification of coronary artery lesions would represent a major advance in cardiac care. Coronary magnetic resonance artery and vessel wall imaging have made significant progress over the past few years. Recent clinical studies have yielded promising results, but the accuracy is not yet high enough for clinical use. The proposed research project proposes new techniques to improve the accuracy and reliability of both magnetic resonance coronary angiography and coronary wall imaging. A period of technical development will be followed by a comparative study of the optimized coronary artery imaging methods with x-ray angiography and intravascular ultrasound in patients with suspected coronary artery disease. This project will combine a proven technical program with constant clinical feedback to facilitate the improvement and refinement of the methods. Relevance: This research project proposes to develop and test new methods for imaging the heart. These new methods are designed to detect and evaluate coronary artery disease, which causes chest pain and heart attacks. The new methods are noninvasive, so they could allow diagnosis of heart disease with less risk and discomfort to the patient than existing methods.

描述（由申请人提供）：该研究项目的目标是开发和评估一套使用磁共振成像（MRI）进行无创冠状动脉成像的新技术。由于冠状动脉疾病仍然是美国死亡的主要原因，因此一种能够准确检测和量化冠状动脉病变的无创冠状动脉成像方法将代表心脏护理的重大进步。冠状动脉磁共振动脉和血管壁成像在过去几年中取得了重大进展。最近的临床研究取得了有希望的结果，但准确性还不够高，无法用于临床。拟议的研究项目提出了新技术来提高磁共振冠状动脉造影和冠状动脉壁成像的准确性和可靠性。经过一段时间的技术开发，将对疑似冠状动脉疾病患者的优化冠状动脉成像方法与 X 射线血管造影和血管内超声进行比较研究。该项目将把经过验证的技术计划与持续的临床反馈相结合，以促进方法的改进和完善。相关性：该研究项目提议开发和测试心脏成像的新方法。这些新方法旨在检测和评估导致胸痛和心脏病发作的冠状动脉疾病。新方法是非侵入性的，因此与现有方法相比，它们可以在诊断心脏病时风险和患者不适更小。