CHILDREN'S NEUROPHYSIOLOGICAL COGNITIVE ASSESSMENT TEST

儿童神经生理认知评估测试

• 批准号: 7105075
• 负责人: ALAN S GEVINS
• 金额: $ 35.3万
• 依托单位: SAM TECHNOLOGY, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-05 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7105075
• 关键词: attention deficit disorder; behavior test; behavioral /social science research tag; brain injury; clinical research; cognition; diagnosis design /evaluation; electroencephalography; epidemiology; epilepsy; human subject; memory; mental health information system; middle childhood (6-11); neurophysiology; neuropsychological tests; patient oriented research; psychometrics; sleep disorders

DESCRIPTION (provided by applicant): Children and adolescents can suffer from a variety of conditions associated with abnormalities in behavior and cognitive brain function. This project will create a tool for assessing cognitive brain function in juvenile populations that is robust, repeatable, and free of cultural bias. It builds on innovative methods we have developed that combine task-related measures of response speed and accuracy with concomitant monitoring of neurophysiologic signals. We have so far established that such combined measures improve sensitivity for detecting the neurocognitive effects of medical treatments, help to separate effects due to variations in level of effort or alertness from those related to the regulation of attention and memory, are stable over time in the absence of developmental or medical changes, and are highly correlated with conventional measures of cognitive ability. However these methods are currently limited to comparing a patient's post-treatment test results to that patient's own pre-treatment baseline. This limitation is analogous to a thermometer that only tells whether a patient's temperature changed from the last measurement or an automobile whose speedometer shows change in miles per hour from yesterday. The current project is concerned with overcoming this limitation by utilizing age-matched reference groups to derive assessments of the neural correlates of sustained attention and working memory that can be used to gauge whether a child's neurocognitive ability is within normal bounds and whether it follows a typically maturational progression when tested repeatedly over an extended period. This will be accomplished in Phase II by collecting and analyzing a normative database that will enable comparison of a child's behavioral and neural responses with those of healthy age-matched peers, as well as comparison of any changes observed over time to those which would be expected as a result of normal maturational processes. The improved measures will then be validated by application to data collected from children with several clinical disorders that affect neurocognitive function including sleep disorders, epilepsy, ADHD and mild traumatic head injury. The resulting method will be embodied in a first-of-its-kind, highly automated Children's Neurophysiologic Cognitive Assessment Test (CNCAT). Because there is a large population of children that could benefit from assessment with the CNCAT in conjunction with their medical care, the test has a promising commercial future.

描述（由申请人提供）：儿童和青少年可能患有多种与行为和认知脑功能异常相关的疾病。该项目将创建一种用于评估青少年群体认知大脑功能的工具，该工具稳健、可重复且没有文化偏见。它建立在我们开发的创新方法的基础上，将响应速度和准确性的任务相关测量与神经生理信号的伴随监测结合起来。到目前为止，我们已经确定，这种综合措施可以提高检测药物治疗的神经认知效应的灵敏度，有助于将由于努力或警觉性水平变化而产生的影响与与注意力和记忆调节相关的影响分开，并且随着时间的推移，这些措施在神经认知方面是稳定的。不存在发育或医学变化，并且与认知能力的常规测量高度相关。然而，这些方法目前仅限于将患者的治疗后测试结果与患者自己的治疗前基线进行比较。这种限制类似于只能告诉病人体温与上次测量相比是否发生变化的温度计，或者汽车的车速表显示与昨天相比每小时英里数的变化。当前的项目致力于克服这一限制，通过利用年龄匹配的参考组来评估持续注意力和工作记忆的神经相关性，可用于衡量儿童的神经认知能力是否在正常范围内以及是否遵循典型的认知能力。经过长时间反复测试后的成熟进程。这将在第二阶段通过收集和分析规范数据库来实现，该数据库将能够将儿童的行为和神经反应与健康年龄匹配的同龄人的行为和神经反应进行比较，并将随着时间的推移观察到的任何变化与预期的变化进行比较作为正常成熟过程的结果。然后，改进的措施将通过应用从患有影响神经认知功能的几种临床疾病的儿童收集的数据来验证，这些疾病包括睡眠障碍、癫痫、多动症和轻度创伤性头部损伤。由此产生的方法将体现在首个高度自动化的儿童神经生理认知评估测试（CNCAT）中。由于大量儿童可以受益于 CNCAT 的评估及其医疗保健，因此该测试具有广阔的商业前景。