Region VI Center for Biodefence and Emerging Infections

第六区生物防御和新发感染中心

基本信息

批准号：
7186647
负责人：
DAVID H WALKER
金额：
$ 1070.1万
依托单位：
UNIVERSITY OF TEXAS MED BR GALVESTON
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-04 至 2009-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7186647
关键词：
Acute Adjuvant Aerosols Algorithms Alphavirus Alveolar Macrophages Animal Model Animals Antibiotics Antigens Antiviral Agents Arenavirus Arkansas Arts Attenuated Vaccines Bacillus anthracis Bacillus anthracis spore Biological Assay Biology Biomedical Research Biomedical Technology Bioterrorism Brucella Brucella melitensis Brucellosis Categories Centers for Disease Control and Prevention (U.S.)Clinical Sciences Code Collaborations Communicable Diseases Computational Biology Computer Analysis Containment Core Facility Cowpox Coxiella burnetii Creativeness Cultured Cells Dengue Detection Development Diagnosis Diagnostic Diagnostic Procedure Early Diagnosis Early identification Emerging Communicable Diseases Endopeptidases Evaluation Facility Construction Funding Category Filovirus Flavivirus Francisella tularensis Future Generations Genes Genetic Genetic Structures Genomics Goals Human Immune response Immunity Immunization In Vitro Infection Institution Interdisciplinary Study Knowledge Lassa Fever Louisiana Methods Microarray Analysis Mission Modeling Molecular Monoclonal Antibodies Mus Mutation National Institute of Allergy and Infectious Disease New Mexico Oklahoma Orthobunyavirus Pathogenesis Pathway interactions Peptide Hydrolases Pharmaceutical Preparations Poxviridae Process Production Protease Inhibitor Proteins Proteomics Q Fever Range Recombinants Replicon Reproduction spores Research Research Infrastructure Research Project Grants Resources Rickettsia prowazekii Rift Valley Fever Rift Valley fever virus Rodent Safety Scientist Screening procedure Services Site Smallpox Structure Subunit Vaccines System Technology Texas Therapeutic Therapeutic Agents Translating Translational Research Tularemia Typhus United States Food and Drug Administration Vaccines Venezuelan Equine Encephalomyelitis Viral Viral Hemorrhagic Fevers Virus Virus Diseases Virus Replication West Nile virus Western Equine Encephalomyelitis attenuation base biodefense biothreat career cytokine drug development drug discovery genetic profiling high throughput screening immunogenicity infectious disease model laboratory facility mutant nonhuman primate novel novel diagnostics novel strategies novel therapeutics novel vaccines outcome forecast pathogen positional cloning prevent prognostic programs rapid technique research and development response scale up small molecule libraries therapeutic target therapeutic vaccine tool vaccine development virus identification

项目摘要

DESCRIPTION (provided by applicant): In response to NIAID's call for the creation of strong infrastructure and multifaceted research and development activities applying the best basic, translational, and clinical science to the generation of new diagnostic, therapeutic and vaccine countermeasures for Category A, B, and C pathogens posing threats as agents of bioterrorism, 22 institutions in Texas, New Mexico, Oklahoma, Arkansas, and Louisiana have combined their energy, creativity, and resources to propose creation of the Region Vl Center of Excellence for Biodefense and Emerging Infectious Diseases (Region Vl RCE). Nine scientific cores will provide access to state-of-the-art proteomics, genomics, standardized small animal and non-human primate models of infectious diseases, BSL-4 laboratory facilities, and GLP scale-up production, as well as crosscutting functions in computational biology and a streamlined process for translational development of vaccines and drugs leading to FDA approval. A wealth of scientific expertise on biothreat agents and contemporary biomedical technology will be applied to establishing the scientific basis and translating it through 11 major research projects, 3 developmental research projects, and 4 career development projects to the development of vaccines against Rift Valley fever, tularemia, smallpox, Venezuelan, eastern, and western equine encephalitis, brucellosis, and typhus; new therapeutic agents against Bacillus anthracis (including the spore), arenaviruses, filoviruses, alphaviruses, flaviviruses, and poxviruses, as well as novel approaches to synthesis of chemical libraries that will promote future drug discovery; and advanced diagnostic methods for Q fever and typhus as well as computational analysis of all host response biosignatures observed within the RCE for the construction of diagnostic and prognostic algorithms and analysis of host responses to infection and immunization. A consistently strong spirit of cooperation among traditionally competing institutions has established an interlocking network of projects, cores, and administration that will strengthen and flourish as the Center is implemented. The guidance of this network of interactive research projects and core resource facilities will be executed under a comprehensive administrative plan to contribute substantially to the nation's biodefense mission by fulfilling a carefully crafted scientific strategy on a common theme; Collaborations for host-pathogen biology based development of novel vaccines, diagnostics, and therapeutics against biothreat agents.

描述（由申请人提供）：响应 NIAID 的号召，建立强大的基础设施和多方面的研究和开发活动，应用最好的基础、转化和临床科学来为 A、B 类产生新的诊断、治疗和疫苗对策和 C 病原体构成生物恐怖主义威胁，得克萨斯州、新墨西哥州、俄克拉荷马州、阿肯色州和路易斯安那州的 22 个机构联合其精力、创造力和资源，提议建立第六区生物恐怖主义中心卓越的生物防御和新发传染病（VI 区 RCE）。九个科学核心将提供最先进的蛋白质组学、基因组学、标准化小动物和非人类灵长类传染病模型、BSL-4 实验室设施、GLP 规模化生产以及跨领域功能。计算生物学以及疫苗和药物转化开发的简化流程，从而获得 FDA 批准。生物威胁制剂和当代生物医学技术方面丰富的科学专业知识将用于建立科学基础，并通过 11 个重大研究项目、3 个发展研究项目和 4 个职业发展项目将其转化为针对裂谷热、兔热病的疫苗的开发、天花、委内瑞拉马脑炎、东部和西部马脑炎、布鲁氏菌病和斑疹伤寒；针对炭疽杆菌（包括孢子）、沙粒病毒、丝状病毒、甲病毒、黄病毒和痘病毒的新治疗剂，以及将促进未来药物发现的化学库合成新方法； Q 热和斑疹伤寒的先进诊断方法，以及在 RCE 中观察到的所有宿主反应生物特征的计算分析，用于构建诊断和预后算法以及分析宿主对感染和免疫的反应。传统竞争机构之间一贯强烈的合作精神建立了一个由项目、核心和管理组成的环环相扣的网络，随着该中心的实施，该网络将得到加强和蓬勃发展。该互动研究项目和核心资源设施网络的指导将在一项全面的行政计划下执行，通过实现针对共同主题的精心设计的科学战略，为国家的生物防御使命做出重大贡献；基于宿主-病原体生物学的合作，开发针对生物威胁因子的新型疫苗、诊断方法和治疗方法。