Molecular and Cellular Regulation of Tolerance

耐受性的分子和细胞调节

• 批准号: 7257209
• 负责人: John G Monroe
• 金额: $ 117.71万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-15 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7257209
• 关键词: Molecular; Cellular; Regulation; Tolerance

DESCRIPTION (provided by applicant): This is a proposal to continue funding for a Program to study the molecular mechanisms involved in the induction and maintenance of immune system unresponsiveness and tolerance. Three investigators are unified by the common theme that tolerance is a complex process in which the inherent responsiveness of immune cells, as well as interactions with their anatomical microenvironment, play pivotal roles in determining responsiveness to self- and pathogen-associated antigens. In keeping with the overall theme of the Program Project, the projects proposed in this renewal will consider mechanistic aspects of tolerance in the context of the interactive nature of the immune system. Accomplishments by the individual investigators in this Program during the last funding period include the design and characterization of experimental models that are now amenable to meaningful mechanistic analysis. These are intended to provide methodologies and insights that will continue to bridge the three projects, thereby facilitating synergy and increased scientific scope to the progress of the individual laboratories. Dr. Mark Greene has been replaced by a new member of the Program, Dr. Yongwon Choi. Dr. Choi will study the role of TRANCE in peripheral T cell homeostasis and unresponsiveness to endogenous antigen. An administrative core will provide budget oversight, secretarial support for manuscript preparation and progress reports, as well as logistical support for scheduling investigator meetings and travel arrangements of consultants. The past and future integration of the three laboratories will enhance the scientific quality and productivity to a degree that results in progress that will be greater than the sum of the individual laboratories.

描述（由申请人提供）：这是一项提议，以继续为程序提供资金，以研究与免疫系统诱导和维持有关的分子机制的无反应和耐受性。三个研究者的共同主题统一了公共性，即公差是一个复杂的过程，在该过程中，免疫细胞的固有反应性以及与解剖学微环境的相互作用在确定对自我和病原体相关抗原的反应性方面发挥了关键作用。为了与计划项目的整体主题保持一致，本续约中提出的项目将在免疫系统的互动性质中考虑宽容的机械方面。在最后一个资金期间，该计划中各个研究人员的成就包括现已适合有意义的机械分析的实验模型的设计和表征。这些旨在提供方法和见解，这些方法和见解将继续桥接这三个项目，从而促进协同作用，并提高了个人实验室进步的科学范围。马克·格林（Mark Greene）博士已由该计划的新成员Yongwon Choi博士取代。 Choi博士将研究TR在周围T细胞稳态中的作用，并且对内源性抗原的反应无反应。行政核心将为手稿准备和进度报告提供预算监督，秘书支持，以及为调查人员会议安排会议和顾问旅行安排的后勤支持。这三个实验室的过去和未来整合将提高科学质量和生产力，从而导致进步的程度大于单个实验室的总和。