Creating a Synthetic Platform for Understanding and Exploiting Glycoconjugates

创建一个理解和利用糖复合物的合成平台

• 批准号: EP/E000614/1
• 负责人: Benjamin Davis
• 金额: $ 82.3万
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2007
• 资助国家: 英国
• 起止时间: 2007 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FE000614%2F1
• 关键词: Creating; Synthetic; Platform; Understanding; Exploiting

The evidence for the importance of carbohydrates in biology is increasing exponentially. Unlike other biomolecules (lipids, proteins, nucleosides) significant expertise is needed in the construction of corresponding glycoconjugate probes used to understand and exploit this biology: for example, no automated oligosaccharide synthesizer to date exists for the construction of all the glycoside linkages. The possible permutations for something as simple as the hexasaccharide structures stretch to greater than 1.05 x 1012 possible combinations. This level of complexity highlights that synthesis of glycoconjugates must be guided by functional design, and cannot simply be achieved through random synthesis of all possible combinations. There are a number of startling and challenging high-risk problems that exist in the field of glycoscience that the Platform would allow us to tackle. The risk is high, the challenges of complexity great (due, in part, to the typical lack of direct genetic control of glycoconjugate synthesis within biology) but the potential rewards are tremendous.

碳水化合物在生物学中的重要性的证据正在呈指数级增长。与其他生物分子（脂质、蛋白质、核苷）不同，在构建用于理解和利用这种生物学的相应糖缀合物探针时需要大量的专业知识：例如，迄今为止不存在用于构建所有糖苷键的自动化寡糖合成器。对于像六糖结构这样简单的东西来说，可能的排列可以延伸到超过 1.05 x 1012 种可能的组合。这种复杂程度凸显了糖复合物的合成必须以功能设计为指导，而不能简单地通过随机合成所有可能的组合来实现。糖科学领域存在许多令人震惊且具有挑战性的高风险问题，该平台将使我们能够解决这些问题。风险很高，复杂性的挑战也很大（部分原因是生物学中通常缺乏对复合糖合成的直接遗传控制），但潜在的回报是巨大的。

项目成果

Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis.

• DOI: 10.1038/nchembio.539
• 发表时间: 2011-04
• 期刊: NATURE CHEMICAL BIOLOGY
• 影响因子: 14.8
• 作者: Backus, Keriann M.;Boshoff, Helena L.;Barry, Conor S.;Boutureira, Omar;Patel, Mitul K.;D'Hooge, Francois;Lee, Seung Seo;Via, Laura E.;Tahlan, Kapil;Barry, Clifton E., III;Davis, Benjamin G.
• 通讯作者: Davis, Benjamin G.

Direct Biocatalytic Conversion of Carbon Dioxide: Towards a Formic Acid Economy

二氧化碳的直接生物催化转化：迈向甲酸经济

• 发表时间: 2007
• 期刊: in preparation
• 作者: A Celik

Creating new Tools for a Formic Acid Economy: Cloning & Structure of Novel Dehydrogenases

为甲酸经济创造新工具：克隆

• 发表时间: 2007
• 期刊: in preparation
• 作者: A Celik

Microparticles bearing RGD peptide promote integrin avß3-dependent platelet adhesion in isolated, pressurized cerebral artery

携带 RGD 肽的微粒促进分离的加压脑动脉中整合素 avä3 依赖性血小板粘附

• 发表时间: 2013
• 期刊: FASEB JOURNAL
• 影响因子: 4.8
• 作者: Bagi Zsolt

Multimeric microparticles of iron oxide (mMPIO) for dual modality molecular imaging with CT & MRI

用于 CT 双模态分子成像的氧化铁多聚微粒 (mMPIO)

• 发表时间: 2014
• 期刊: EUROPEAN HEART JOURNAL
• 影响因子: 39.3
• 作者: Aljabali A. A. A.