PRICE: Pivotal Research in Cardiology in the Elderly

PRICE：老年人心脏病学的关键研究

• 批准号: 7390756
• 负责人: MICHAEL W RICH
• 金额: $ 5.59万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-04-01 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7390756
• 关键词: Accounting; Address; African American; Age; Age-Years; Aging; Aortic Valve Stenosis; Area; Atrial Fibrillation; Award; Basic Science; Behavior; Cardiology; Cardiovascular Diseases; Cardiovascular system; Caring; Cause of Death; Cessation of life; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Complex; Condition; Coupled; Development; Diagnosis; Disease; Elderly; Electronics; Electrophysiology (science); Epidemiology; Exhibits; Exposure to; Fostering; Frail Elderly; Functional disorder; Future; General Population; Genetic; Geriatrics; Health Services; Heart Valve Diseases; Heart failure; High Prevalence; Hispanic Americans; International; Investigation; Knowledge; Light; Methodology; Minority Groups; Mitral Valve Insufficiency; Molecular Biology; Molecular and Cellular Biology; Morbidity - disease rate; Not Hispanic or Latino; Numbers; Outcome; Pattern; Persons; Population; Prevention; Prevention strategy; Preventive; Printing; Proceedings and Conferences; Proceedings, Conference; Public Health; Publications; Qualifying; Range; Rate; Recommendation; Request for Proposals; Research; Research Activity; Research Design; Research Personnel; Scientist; Series; Sinus; Smoking; Source; State-of-the-Art Reviews; Structure; Syndrome; Travel; United States; Woman; acute coronary syndrome; age effect; age related; attributable mortality; base; cardiovascular risk factor; career; day; design; disability; expectation; heart rhythm; improved; interdisciplinary collaboration; interest; knowledge base; member; men; middle age; mortality; older men; programs; size; symposium

DESCRIPTION (provided by applicant): Cardiovascular disease (CVD) is the leading cause of death and major disability in older adults, and approximately 85% of all cardiovascular deaths in the U.S. occur in persons over 65 years of age. Moreover, although major advances over the past 30 years have led to greatly enhanced understanding of cardiovascular diseases in the elderly, critically important questions remain unanswered. The Pivotal Research in Cardiovascular Syndromes in the Elderly (PRICE) conference series was conceived in 1999 as a mechanism to concisely review state-of-the-art knowledge, identify critical gaps in that knowledge, and define a prioritized agenda for cardiovascular aging research in the ensuing 5-10 years. PRICE-1 (1999) provided an overview of major topics, with the expectation that subsequent PRICE symposia would explore specific topics in greater detail. Accordingly, PRICE-2 (2002) focused on acute coronary syndromes in the elderly, and the present proposal requests support for PRICE-3 (2004), PRICE-4 (2006), and PRICE-5 (2008), which will address heart failure, electrophysiology and rhythm disorders, and preventive cardiology, respectively. Specific aims for each PRICE conference include: 1. convene an international cadre of distinguished scientists and clinical investigators to define the current knowledge base and identify key gaps in knowledge that should serve as targets for future research; 2. foster interdisciplinary collaborations to enhance understanding of the complex interactions between aging and CVD; 3. stimulate career interests and development of promising young investigators; and 4. widely disseminate the conference's findings, including a broad-based but prioritized research agenda in each of the major topic areas. These objectives will be accomplished through a structured series of presentations and discussions addressing key topics ranging from molecular biology and genetics to epidemiology, clinical trials, and geriatrics. A Young Investigator Travel Award Program will provide support for attendance by qualified young investigators, and specific efforts will be made to engage women and minority group members at all levels of participation. Significance. CVD is an enormous public health problem in the U.S., and the magnitude of this problem is likely to increase exponentially as the population ages over the next several decades. It is therefore essential to accelerate the pace of research in cardiovascular aging and CVD in the elderly, and the PRICE series of conferences will provide specific recommendations regarding potentially fruitful avenues of investigation that are likely to have the greatest impact in advancing understanding of the fundamental mechanisms responsible for cardiovascular aging and in improving clinical care and outcomes for older adults with CVD.

描述（由申请人提供）：心血管疾病（CVD）是老年人死亡和主要残疾的主要原因，美国大约85％的患者在65岁以上的人中发生。此外，尽管过去30年中的重大进展导致人们对老年人心血管疾病的理解大大增强，但至关重要的问题仍然没有解决。 1999年将老年人（价格）会议系列中心血管综合征的关键研究作为一种机制，是一种简化最先进的知识，确定该知识中的关键差距，并定义了在随之而来的5 - 10年中为心血管老化研究的优先级议程。 Price-1（1999）概述了主要主题，并期望随后的价格研讨会将更详细地探讨特定主题。因此，Price-2（2002）着重于老年人的急性冠状动脉综合症，本提案请求对Price 3（2004），Price-4（2006）和Price-5（2008）的支持，该提案将分别解决心脏失败，电生理学和节奏疾病以及预防性心脏病学。每个价格会议的具体目的包括：1。召集国际杰出科学家和临床研究人员的国际干部，以定义当前的知识库并确定知识的关键差距，这些差距应作为未来研究的目标； 2。培养跨学科的合作，以增强对衰老与CVD之间复杂相互作用的理解； 3。刺激职业兴趣和有前途的年轻调查员的发展；和4。广泛传播了会议的发现，包括在每个主要主题领域中基于广泛但优先的研究议程。这些目标将通过一系列结构化的演讲和讨论来实现，这些讨论涉及从分子生物学和遗传学到流行病学，临床试验和老年医学的关键主题。一项年轻的调查员旅行奖计划将为合格的年轻调查员提供支持，并为与各级参与的妇女和少数族裔成员互动做出具体努力。意义。 CVD在美国是一个巨大的公共卫生问题，随着未来几十年的人口年龄的增长，该问题的规模可能会呈指数增长。因此，加速老年人心血管衰老和CVD的研究步伐至关重要，而且价格系列会议将提供有关潜在富有成果的调查途径的具体建议，这些建议可能会促进对负责对心血管衰减和改善临床护理和改善Outcems Outcomes for Eldece and Outcomes for Eldece and Outcomes和Outcems Outcems for Elders for Elders for Elders for Eldece and Outcems and Outcems for Elders for Elders for Elders auts Outcems and Cvs and Cv and CV的基本机制的最大影响。

项目成果

Epidemiology of atrial fibrillation.

心房颤动的流行病学。

• DOI: 10.4414/smw.2009.12500
• 发表时间: 2009
• 期刊: Swiss medical weekly
• 影响因子: 2.9
• 作者: Conen,D;Osswald,S;Albert,CM
• 通讯作者: Albert,CM

Fourth Pivotal Research in Cardiology in the Elderly (PRICE-IV) Symposium--electrophysiology and heart rhythm disorders in the elderly: mechanisms and management.

第四届老年人心脏病学关键研究 (PRICE-IV) 研讨会——老年人电生理学和心律失常：机制和治疗。

• DOI: 10.1111/j.1076-7460.2007.07395.x
• 发表时间: 2007
• 期刊: The American journal of geriatric cardiology
• 作者: Rich,MichaelW;Curtis,AnneB;PRICE-IVInvestigators
• 通讯作者: PRICE-IVInvestigators

Fifth Pivotal Research in Cardiology in the Elderly (PRICE-V) Symposium: Preventive Cardiology in the Elderly--executive summary. Part II: afternoon session.

第五届老年人心脏病学关键研究 (PRICE-V) 研讨会：老年人预防心脏病学 - 执行摘要。

• DOI: 10.1111/j.1751-7141.2009.00047.x
• 发表时间: 2010
• 期刊: Preventive cardiology
• 作者: Rich,MichaelW;Mensah,GeorgeA;PRICE-VInvestigators
• 通讯作者: PRICE-VInvestigators

Third pivotal research in cardiology in the elderly (PRICE-III) symposium: heart failure in the elderly: mechanisms and management.

第三届老年人心脏病学关键研究（PRICE-III）研讨会：老年人心力衰竭：机制和治疗。

• DOI: 10.1111/j.1076-7460.2005.04658.x
• 发表时间: 2005
• 期刊: The American journal of geriatric cardiology
• 作者: Rich,MichaelW;Kitzman,DalaneW;PRICE-IIIOrganizingCommittee;PRICE-IIIInvestigators
• 通讯作者: PRICE-IIIInvestigators