Gordon Conference on "Phosphorylation and G Protein Signaling Networks"

戈登会议“磷酸化和 G 蛋白信号网络”

基本信息

批准号：
7385961
负责人：
Henrik G. Dohlman
金额：
$ 1.27万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2006
资助国家：
美国
起止时间：
2006-04-01 至 2009-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7385961
关键词：
5&apos -AMP-activated protein kinase Academia Actins Address Affect Age Aging Agonist Apoptotic Arabidopsis Area Asians Attention Biochemical Biochemical Reaction Biochemistry Bioinformatics Biological Biological Assay Biology Blood Brain Breeding California Canada Cardiovascular Diseases Cardiovascular Physiology Catalytic Domain Categories Cell Communication Cell Cycle Regulation Cell Death Cell Differentiation process Cell Polarity Cell Proliferation Regulation Cell Size Cell physiology Cells Cellular biology Chemicals Chemistry Class Clinical Collaborations Colorado Communicable Diseases Communication Complement Complex Computer Simulation Congenital Abnormality Count Country Cyclic AMP Cyclic Nucleotides Cytoskeleton DNA Tumor Viruses Databases Dependence Detection Development Diabetes Mellitus Disabled Persons Discipline Disease Disease Pathway Disease Resistance Disruption Drosophila eye Endopeptidases Enzyme Inhibitor Drugs Enzyme Inhibitors Enzymes Equilibrium Eukaryota Eukaryotic Cell Event Faculty Failure Family Feedback Female Filament Fluorescence Focal Adhesions Fostering Foundations Funding G Protein-Coupled Receptor Genes G Protein-Coupled Receptor Signaling G-Protein-Coupled Receptors GTP-Binding Proteins Gene Expression Gene Silencing Gene Targeting Genes Genetic Genetic Programming Genetic Transcription Genomics Germany Goals Grant Growth Growth Factor Growth and Development function Guidelines Health Heart Hispanics Human Hypertension Immune Immune response Immune system Individual Induction of Apoptosis Industry Inflammation Inflammatory Institution Insulin Insulin Resistance International Intervention Knock-out Knowledge Learning Link Location Longevity Lung MAPK8 gene MEKs Mails Maine Malignant Neoplasms Maps Mass Spectrum Analysis Massachusetts Mediating Membrane Mesenchymal Stem Cells Metabolic Metabolic Diseases Metabolism Methods Michigan Mining Minority Minority Groups Minority-Serving Institution Mitotic Cell Cycle Modeling Modification Molecular Molecular Biology Molecular Profiling Molecular and Cellular Biology Monitor Morphogenesis Muscle Musculoskeletal Diseases Names Neoplasm Metastasis Nerve Degeneration Netherlands Neurons New England Nobel Prize North Carolina Nucleic Acids Numbers Nurses Nutrient Obesity Operative Surgical Procedures Oral Participant Pathogenesis Pathway interactions Pattern Formation Peptide Hydrolases Phagocytosis Inhibition Pharmacologic Substance Pheromone Phosphorylation Phosphotransferases Physiology Plants Play Post-Translational Protein Processing Postdoctoral Fellow Poxviridae Principal Investigator Process Production Protein Binding Domain Protein Engineering Protein Isoforms Protein Kinase Protein Tyrosine Kinase Protein Tyrosine Phosphatase Proteins Proteomics Published Comment RNA Interference Receptor Signaling Recruitment Activity Regulation Research Research Personnel Resolution Role Saccharomyces cerevisiae San Francisco Scaffolding Protein Schedule Scientist Scotland Screening procedure Second Messenger Systems Senior Scientist Shapes Signal Pathway Signal Transduction Signal Transduction Pathway Signaling Molecule Site Small RNA Societies Staging Stress Students System T-Cell Receptor TNF Receptor-Associated Factors Texas Therapeutic Therapeutic Intervention Thinking Time Title Training Transcriptional Activation Transforming Growth Factor beta Tyrosine Kinase Inhibitor Ubiquitin Underrepresented Minority United States National Institutes of Health Universities Vibrio parahaemolyticus Virulence Factors Week Wheelchairs Woman Work World Health Organization Yeasts Yersinia base biological adaptation to stress career cell growth cell growth regulation cell motility cell type chemical genetics concept cytokine day design detection of nutrient developmental disease direct application disability driving force experience follow-up forkhead protein frontier handicapping condition human FRAP1 protein human disease immunological synapse innovation insight interest knowledge base macrophage medical schools member metabolomics metaplastic cell transformation microbial mouse model multidisciplinary new technology novel novel strategies novel therapeutics pathogen posters professor programs protein protein interaction receptor response scaffold second messenger sensor small molecule small molecule libraries social sorting nexins src-Family Kinases success symposium therapeutic target trafficking transcription factor yeast genetics

项目摘要

DESCRIPTION (provided by applicant): We request partial funding support for operation of the Gordon Research Conference (GRC) on Phosphorylation and G protein Signaling Networks. This conference, formerly known as "Second Messengers and Protein Phosphorylation" has been held annually since 1970, and has been a premier venue for the presentation of new discoveries in signal transduction. Investigators who initiated and attended this meeting from its inception were leaders who established the field of signal transduction, including several who have received Nobel Prizes (e.g., Earl Sutherland, Al Oilman, Stanley Cohen, Edwin Krebs, Edmond Fischer, Paul Nurse). The conference focuses on signal transduction mechanisms that regulate cell growth, differentiation, survival, and metabolism. A full understanding of these signaling mechanisms is scientifically and clinically important because their failure plays a direct role in contemporary health problems that affect millions of people worldwide, such as diabetes, obesity, cancer, aging, infectious disease, cardiovascular disease, neurodegeneration, and developmental disorders. Meeting topics cover networks of intracellular signaling pathways from a mechanistic viewpoint, and continue to highlight cutting edge discoveries by emerging from studies focused on protein covalent modifications, protein-protein and protein-nucleic acid interactions, and control by small molecule effectors. The University of New England became the new site for this meeting in 2005, and provides a rustic and handicapped-accessible venue to promote open interaction among participants. The 2006 meeting will be held from Sunday night June 11 and end on Thursday evening June 16. The speakers are encouraged to integrate biochemical, structural, cell-biological, and genomic approaches that provide a comprehensive understanding of the molecular aspects of signaling mechanisms as they relate to disease. Two plenary speakers were selected to set the stage for the conference and to challenge the participants to think about signal transduction from perspectives of the chemistry-biology interface. The conference will consist of 8 sessions, each with a discussion leader and 3-5 speakers, selected from investigators who have made important recent contributions. At least 45% of the invited speakers are either women or members of minority groups and 23% of invited speakers are new investigators (Asst/Assoc. level). Speakers in each session will develop the important paradigms in signal transduction. The emphasis will be on structural and functional understanding of the defining molecular mechanisms and their implications for disease and potential treatment strategies. The co-chairs will select 135 participants from applicants, including representatives from industry and academia, senior scientists, postdoctoral fellows and graduate students. A special effort will be made to recruit minority participants and participants from industry by a direct emailing program. Participants will be encouraged to present posters on new and interesting results each afternoon. Importantly, the conference provides a forum for young investigators to see the connection between fundamental scientific inquiry and the application of scientific methods to the design of efficacious interventions for human disease. To emphasize this goal, 8 poster presentations that complement the themes of the meeting will be selected for short oral presentations during the main sessions.

描述（由申请人提供）：我们要求针对戈登研究会议（GRC）的磷酸化和G蛋白信号网络的部分资金支持。该会议以前称为“第二使者和蛋白质磷酸化”，自1970年以来每年举行，并且一直是信号转导新发现的首要场所。发起并参加此次会议的调查人员是建立信号转导领域的领导者，其中包括几位获得诺贝尔奖的人（例如，伯爵·萨瑟兰（Earl Sutherland），阿尔·奥利曼（Al Al Oilman），斯坦利·科恩（Stanley Cohen），埃德温·克雷布斯（Edwin Krebs），埃德蒙·菲斯（Edmond Fischer），保罗·保罗（Paul Nurse））。该会议的重点是调节细胞生长，分化，生存和代谢的信号转导机制。对这些信号机制的全面了解在科学和临床上很重要，因为它们的失败在影响全球数百万人的当代健康问题中起着直接作用，例如糖尿病，肥胖，癌症，癌症，衰老，传染病，心血管疾病，神经变性，神经变性和发育障碍。符合主题涵盖了从机械角度来涵盖细胞内信号通路的网络，并通过从研究重点从蛋白质共价修饰，蛋白质 - 蛋白质和蛋白质核酸相互作用的研究中出现，并继续突出显示前沿发现，并通过小分子效应来控制。新英格兰大学成为2005年这次会议的新网站，并提供了一个质朴和残障的场地，以促进参与者之间的公开互动。 2006年的会议将于6月11日星期日举行，并于6月16日星期四结束。鼓励演讲者整合生化，结构，细胞生物学和基因组方法，这些方法对与疾病有关的信号机制的分子方面提供了全面的了解。选择了两名全体会议者为会议奠定了基础，并挑战参与者从化学生物学界面的角度考虑信号转导。该会议将包括8个会议，每个会议都有一个讨论负责人和3-5位演讲者，他们是从研究人员做出了重要贡献的调查人员中选出的。至少有45％的受邀演讲者是妇女或少数群体的成员，而有23％的被邀请的演讲者是新的调查员（ASST/Assoc。Level）。每个会话中的说话者将发展信号转导的重要范例。重点是对定义分子机制的结构和功能理解及其对疾病和潜在治疗策略的影响。共同主席将从申请人中挑选135名参与者，包括工业和学术界的代表，高级科学家，博士后研究员和研究生。将通过直接电子邮件计划招募少数群体参与者和参与者做出特别的努力。每天下午，将鼓励参与者以新有趣的结果介绍海报。重要的是，该会议为年轻的研究人员提供了一个论坛，以查看基本科学探究与科学方法在设计人类疾病有效干预措施上的应用之间的联系。为了强调这一目标，将在主要会议期间选择与会议主题相辅相成的8个海报演示文稿。