Mutagenesis 2008 Gordon Research Conference

诱变 2008 年戈登研究会议

• 批准号: 7481663
• 负责人: Nancy Maizels
• 金额: $ 0.75万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-18 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7481663
• 关键词: Aging; Area; Biological; Collaborations; Critical Pathways; DNA Repair; Development; Fostering; Future; Genetic Recombination; Genetic Transcription; Genomic Instability; Genomics; Goals; Hereditary Disease; Human Genome; Immune response; Investigation; Knowledge; Maintenance; Malignant Neoplasms; Mismatch Repair; Molecular; Mutagenesis; Mutation; Nerve Degeneration; Neurodegenerative Disorders; Oxidative Stress; Pathway interactions; Physiological; Premature aging syndrome; Research; Research Personnel; Therapeutic; design; human disease; programs; symposium

DESCRIPTION (provided by applicant): Mutations initiate and facilitate the progression of a multitude of human diseases, especially cancer and neurodegenerative diseases; and mutagenic repair of DNA damage contributes to aging. The 2008 Gordon Research Conference on Mutagenesis will focus on the molecular mechanisms of mutagenesis that give rise to genomic instability. The goals of this meeting are (1) to explore current knowledge of mutagenesis mechanisms; (2) to identify new avenues of investigation; (3) to define therapeutic strategies for maintenance of genomic integrity; (4) to stimulate collaborations; and (5) to foster the long-term development of this critical research area. The program will specifically focus on advances that provide mechanistic understanding of pathways that maintain the integrity of the human genome, with emphasis on how these pathways intersect genetic disease, cancer, neurodegeneration and aging. The eight sessions will consider: (i) Mutagenesis Due to Blocked Replication and Transcription, (ii) Consequences of Oxidative Stress, (iii) Recombination Induced Genomic Instability, (iv) Physiological Mutagenesis in the Immune Response, (v) Rare Human Diseases Associated with Genomic Instability, Neurodegeneration and Premature Aging, (vi) Low-fidelity Replication and Cancer, (vii) Mechanisms of Mutagenesis, and (viii) Mismatch Repair: the Final Fidelity Check. The molecular and mechanistic emphasis on pathways critical in a variety of biological contexts is designed to attract a unique audience of researchers and propel their future research.

描述（由申请人提供）：突变引发和促进多种人类疾病的进展，尤其是癌症和神经退行性疾病； DNA损伤的诱变修复会导致衰老。 2008年戈登诱变研究会议将重点关注诱变的分子机制，从而导致基因组不稳定性。这次会议的目标是（1）探索当前有关诱变机制的知识； （2）确定新的调查途径； （3）定义维持基因组完整性的治疗策略； （4）刺激合作； （5）促进该关键研究领域的长期发展。该计划将专门关注对维持人基因组完整性的途径的机械理解的进步，重点是这些途径如何与遗传疾病，癌症，神经变性和衰老相交。八个会话将考虑：（i）由于复制和转录的阻滞而引起的诱变，（ii）氧化应激的后果，（iii）在免疫反应中重组引起的基因组不稳定性，（iv）生理诱变，（iv）在免疫反应中（（v）罕见的人类疾病，（v）与基因组不稳定性，神经变性和癌症敏感性（VI）（VI）（VI）（VI）（VI）（VI）（VI）（VI）（VI）诱变的机制和（viii）不匹配修复：最终的保真度检查。在各种生物学环境中至关重要的途径上的分子和机械强调旨在吸引独特的研究人员并推动他们未来的研究。