2009 Biology of Aging Gordon Research Conference
2009年衰老生物学戈登研究会议
基本信息
- 批准号:7613586
- 负责人:
- 金额:$ 5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2008
- 资助国家:美国
- 起止时间:2008-09-30 至 2009-08-31
- 项目状态:已结题
- 来源:
- 关键词:AgeAgingAging-Related ProcessBiologyBiology of AgingCaliforniaClinicalCollaborationsDiabetes MellitusDietary InterventionDiseaseFacultyFundingGeneticGerontologyGoalsHealthHeartHomeostasisHumanImpaired cognitionIndividualInflammationInflammatoryInterventionKnowledgeLifeLongevityMalignant NeoplasmsMolecular and Cellular BiologyMusculoskeletal SystemNerve DegenerationNumbersOrganismPathologyPhysiologyPostdoctoral FellowQuality of lifeRangeResearchResearch PersonnelRoleRunningScienceScientistSocietiesStudentsSystemTimeTranslatingTranslational Researchage relatedbody systemcytokinefrailtyhealthy agingimmunosenescenceimprovedlifestyle interventionnovel therapeuticsprogramssymposiumtherapy development
项目摘要
DESCRIPTION (provided by applicant): Gordon Research Conference have taken place since 1931 and have been a critical venue for the dissemination of new and unpublished ideas in leading fields. The 2009 Gordon Research Conference on The Biology of Aging, titled "Mechanisms of Aging: Key Effectors and Rational Targets" will bring together investigators from the aging field with leaders in understanding the biology of major age-related diseases such as diabetes and cancer. The aging field has reached a point in time where it can seriously discuss the potential of translating scientific progress into clinical or lifestyle interventions that improve lives. In recent years, inflammation has emerged as a key driver of age- related diseases, and will form a continuing thread throughout the conference. We fully anticipate that the discussions and the collaborations set up at the meeting will help set the directions for the field of aging and accelerate the development of interventions to improve quality of life for millions of individuals. Funds are requested to provide partial support for the Gordon Research Conference (GRC) in the Biology of Aging. The theme of the 2009 conference will be "Mechanisms of Aging: Key Effectors and Rational Targets" to be held at the Four Points Sheraton Hotel, Ventura Beach, California from February 15-19, 2009. Drs Janet M Lord and David Sinclair will organize the scientific program. Our aim is to provide funds to support invited speakers, discussion leaders, and junior scientists (postdoctoral fellows, advanced graduate students, or new, junior faculty), who would benefit from and contribute to the conference. The speakers we have invited are internationally recognized for their research on the molecular and cellular biology of aging, the physiology and genetics of aging. We have also placed particular emphasis upon speakers who can contribute to a discussion on inflammation as a pleiotropic effector in the aging process and upon those researchers utilizing current understanding of aging to develop interventions to extend longevity and healthspan. Each of the speakers is a strong communicator of their science who can stimulate lively discussions. The current challenge to biogerontology is to determine how the various age-related changes, at the genetic and functional level, interact to result in loss of homeostasis, frailty and pathology. In particular, this conference will consider the age-related increase in pro-inflammatory cytokines, so-called "Inflammaging", as a candidate pleiotropic effector in the aging process in major organ systems. The conference will thus include sessions on neurodegeneration and cognitive decline, aging of the heart and musculoskeletal systems, the role of aging in cancer, and immunosenescence, with inflammation as a topic running through each session. In addition, it has become clear that several aspects of the aging process are malleable. In recent years, a large number of genetic, pharmacological and dietary interventions have been described that slow down aging in systems ranging from unicellular organisms to humans. This GRC will thus include discussion of interventions for healthy aging. The goals of the conference are: (i) To critically assess progress in the biology of aging; (ii) To utilize knowledge about the biology of aging to understanding age-related decline and major disease of society; and (iii) to emphasize integrative and translational research findings as a means to develop and validate novel therapeutics that could extend human health span.
描述(由申请人提供):戈登研究会议自 1931 年以来一直举办,一直是传播领先领域新的和未发表的想法的重要场所。 2009 年戈登衰老生物学研究会议,题为“衰老机制:关键效应器和合理目标”,将汇集衰老领域的研究人员和了解糖尿病和癌症等与年龄相关的主要疾病的生物学的领导者。老龄化领域已经到了可以认真讨论将科学进步转化为改善生活的临床或生活方式干预措施的潜力的时刻。近年来,炎症已成为年龄相关疾病的关键驱动因素,并将成为整个会议的一个持续主题。我们完全预计,会议上的讨论和合作将有助于为老龄化领域确定方向,并加速开发干预措施,以改善数百万人的生活质量。请求资金为衰老生物学戈登研究会议(GRC)提供部分支持。 2009年会议的主题是“衰老机制:关键效应因素和理性目标”,将于2009年2月15日至19日在加利福尼亚州文图拉海滩四点喜来登酒店举行。Janet M Lord博士和David Sinclair博士将组织会议科学计划。我们的目标是提供资金来支持受邀演讲者、讨论领袖和初级科学家(博士后研究员、高级研究生或新的初级教师),他们将从会议中受益并做出贡献。我们邀请的演讲者因其在衰老的分子和细胞生物学、衰老的生理学和遗传学方面的研究而获得国际认可。我们还特别强调那些能够对炎症作为衰老过程中的多效性效应物进行讨论的演讲者,以及那些利用当前对衰老的理解来开发干预措施以延长寿命和健康寿命的研究人员。每位演讲者都是其科学领域的有力传播者,能够激发热烈的讨论。当前生物老年学面临的挑战是确定遗传和功能水平上的各种与年龄相关的变化如何相互作用,从而导致体内平衡丧失、虚弱和病理。特别是,本次会议将考虑与年龄相关的促炎细胞因子的增加,即所谓的“炎症”,作为主要器官系统衰老过程中的候选多效性效应物。因此,会议将包括关于神经退行性变和认知能力下降、心脏和肌肉骨骼系统衰老、衰老在癌症中的作用以及免疫衰老的会议,其中炎症作为贯穿每个会议的主题。此外,很明显衰老过程的几个方面是可塑的。近年来,大量的遗传、药理学和饮食干预措施被描述,可以延缓从单细胞生物到人类等系统的衰老。因此,本次 GRC 将包括对健康老龄化干预措施的讨论。会议的目标是: (i) 严格评估衰老生物学的进展; (ii) 利用衰老生物学知识来了解与年龄相关的衰退和社会主要疾病; (iii) 强调综合性和转化性研究成果,作为开发和验证可延长人类健康寿命的新疗法的手段。
项目成果
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DAVID A. SINCLAIR其他文献
DAVID A. SINCLAIR的其他文献
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