Center for Gamma-Ray Imaging

伽马射线成像中心

基本信息

批准号：
7271153
负责人：
HARRISON H BARRETT
金额：
$ 94.47万
依托单位：
UNIVERSITY OF ARIZONA
依托单位国家：
美国
项目类别：
财政年份：
1999
资助国家：
美国
起止时间：
1999-08-01 至 2009-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7271153
关键词：
Address Algorithms Anatomic Models Animal Model Animals Applications Grants Area Arizona Arts Authorization documentation Basic Science Biodistribution Biological Biological Models Biomedical Research Cadmium Calibration Cardiac Function Study Cardiology Cerebrum Classification Clinical Code Collaborations Collimator Communities Competence Computer Simulation Computer software Consult Counseling Count Coupled Data Deposition Detection Development Dimensions Economics Educational workshop Electronics Elements Engineering Evaluation Facility Construction Funding Category Faculty Feedback Film Funding Gamma Cameras Gamma Rays Gene Expression Profiling Generations Grant Guidelines Hand Health Services Research Image Image Analysis Information Dissemination Institution Internet Investigation Iodides Isotopes Joints Label Lead Lung Mammary Neoplasms Materials Testing Measurement Mechanics Methodology Methods Modality Modification Mus National Center for Research Resources Nephrology Neuroendocrine Tumors Noise Numbers Object Attachment Online Systems Operative Surgical Procedures Optics Peer Review Performance Personal Satisfaction Photons Physiology Positioning Attribute Positron-Emission Tomography Postdoctoral Fellow Principal Investigator Process Publications Purpose Radioactive Tracers Radiopharmaceuticals Range Rate Rattus Research Resolution Resources Role Selenium Semiconductors Services Silicon Site Spottings Staging Structure Students System Technology Testing Theoretical Studies Thick Thinking Time Tomography, Computed, Scanners Tracer Training Training Programs Translating Tube Ultrafine Universities Work Writing X-Ray Computed Tomography Zinc abstracting base bioimaging cognitive function commercialization computerized data processing concept data acquisition design design and construction detector experience functional genomics gene therapy image reconstruction imaging detector improved molecular imaging novel strategies oncology programs prototype radiotracer reconstruction red mercuric iodide simulation single photon emission computed tomography success technique development technology development

项目摘要

DESCRIPTION (Adapted from Applicant's Abstract): The objectives of the Center for Gamma-Ray Imaging (CGRI) are to develop advanced gamma-ray detectors and imaging systems, to push the limits of spatial and temporal resolution in SPECT and PET, and to make state-of-the-art technology available to our collaborators and to the biomedical research community. Much of the emphasis is on basic research with animal models, but there are many possibilities for translating the technology and the results of the collaborative research into clinical practice. We strive to integrate the components of the P41 mechanism (core technology development, collaborative research, service, dissemination and training) into a comprehensive program that addresses all aspects of gamma-ray imaging, including the radiopharmaceutical, image formation and detection data acquisition and processing and the final biomedical application. The core technology projects include development of new gamma-ray detectors with high sensitivity and high spatial and temporal resolution; development of new computer models and image reconstruction algorithms for SPECT and PET; design and construction of new imaging systems incorporating sophisticated list-mode data-acquisition electronics; objective task-based assessment of image quality as applied to evaluation and optimization of imaging systems and algorithms; and development of new animal models and image-analysis methods for molecular imaging. Collaborative research includes projects in functional genomics, lymphology, nephrology, oncology and cardiology. Dissemination includes supplying imaging hardware and software to our collaborators, as well as workshops and a web site for traditional dissemination of information. Training includes both a formal workshop and hands-on training for our collaborators in Tucson. Service includes performing routine animal studies, testing and calibrating detectors and detector materials, and providing advice on image quality.

描述（根据申请人的摘要改编）：伽马射线成像中心（CGRI）的目标是开发先进的伽马射线探测器和成像系统，以推动SPECT和PET中的空间和时间分辨率的极限，并制造先进的技术我们的合作者和生物医学研究社区可供选择。大部分重点是使用动物模型的基础研究，但是将技术和协作研究结果转化为临床实践的可能性很多。我们努力将p41机制（核心技术开发，协作研究，服务，传播和培训）的组成部分整合到一个全面的计划中，该计划涉及伽马射线成像的各个方面，包括放射性药物，图像形成和检测数据获取和处理以及最终的生物医学应用。核心技术项目包括开发具有高灵敏度以及高空间和时间分辨率的新伽马射线探测器；开发SPECT和PET的新计算机模型和图像重建算法；新成像系统的设计和构建，结合了复杂的列表模式数据收购电子设备；基于目标任务的图像质量评估，用于评估和优化成像系统和算法；以及开发新动物模型和分子成像的图像分析方法。协作研究包括功能基因组学，淋巴科，肾脏学，肿瘤学和心脏病学项目。传播包括向我们的合作者提供成像硬件和软件，以及研讨会和一个用于传统信息传播信息的网站。培训包括对图森合作者的正式研讨会和动手培训。服务包括进行常规动物研究，测试和校准探测器和探测器材料，并提供有关图像质量的建议。