PNI Relations Among Women With Endometrial Cancer During the Perioperative Period

子宫内膜癌女性围手术期 PNI 关系

• 批准号: 7281280
• 负责人: DEIDRE B PEREIRA
• 金额: $ 6.84万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7281280
• 关键词: Abdomen; Accounting; Bilateral; Blood Vessels; Body of uterus; Breast; Buffers; Cancer Etiology; Cancer Patient; Cessation of life; Clinical; Diagnosis; Disease; Disease Progression; Endometrial Carcinoma; Endometrial adenocarcinoma; Epidemiology; Excision; Future; Goals; Growth Factor; Gynecologic; Health; Hydrocortisone; Hysterectomy; Incidence; Interdisciplinary Study; Knowledge; Life Stress; Malignant Female Reproductive System Neoplasm; Malignant Neoplasms; Malignant neoplasm of ovary; Mammalian Oviducts; Neoplasm Metastasis; Newly Diagnosed; Numbers; Nutrient; Operative Surgical Procedures; Outcome; Ovary; Oxygen; Perioperative; Personal Satisfaction; Plasma; Process; Psychosocial Factor; Public Health; Range; Research; Salivary; Salpingo-Oophorectomy; Sampling; Severity of illness; Social support; Staging; Stress; Testing; Tumor Angiogenesis; United States; Uterine Cancer; Uterus; Vascular Endothelial Growth Factors; Woman; Work; biobehavior; cancer surgery; experience; ilium; immunopathology; improved; innovation; mortality; neoplastic cell; psychologic

DESCRIPTION (provided by applicant): Endometrial cancer is the most common gynecologic cancer in the U.S. and the 2nd most deadly gynecologic cancer after ovarian cancer. Although there is an emerging body of research examining psychoneuroimmunologic (PNI) relations in breast and ovarian cancers, no research to our knowledge has examined these relations in endometrial cancer. Furthermore, few studies have examined PNI relations among cancer patients undergoing surgery - a period marked by high psychological and physical stress and high vulnerability to the establishment of metastases. Our long range goal is to improve the health and well- being of women with endometrial cancer. The objective of this application is to assess relations among life stress, diurnal salivary cortisol rhythm (a predictor of disease severity and mortality among cancer patients), and vascular endothelial growth factor (VEGF) (the most potent growth factor to promote tumor angiogenesis, the process by which new blood vessels are formed to supply tumor cells with nutrients and oxygen) among women undergoing endometrial cancer surgery. The central hypothesis of this application is that high life stress will be associated with more abnormal cortisol rhythms and higher VEGF levels during the perioperative period, and that relational health/social support will buffer these relations. This central hypothesis will be tested by pursuing the following specific aims in a sample of newly diagnosed endometrial cancer patients undergoing surgical removal of the uterus, ovaries, and fallopian tubes: (Aim 1) to identify relations among life stress, relational health, and salivary cortisol rhythm, and (Aim 2) to identify relations among life stress, relational health, and VEGF. If our hypothesized relations emerge, it will guide future research examining the extent to which these relations predict clinical outcomes and mortality in endometrial cancer. Our multidisciplinary research group is particularly well-prepared to pursue the proposed work due to our combined experience in biobehavioral and immunopathology research. The proposed study is innovative, because it will be among the first to examine biobehavioral relations among women undergoing cancer surgery. Finally, these results will be significant to public health initiatives, because although endometrial cancer is the 4th most common cancer and 8th leading cause of cancer related death among women, there is a paucity of research examining potential biobehavioral mechanisms of this disease.

描述（由申请人提供）：子宫内膜癌是美国最常见的妇科癌症，也是卵巢癌后第二个致命的妇科癌。尽管有大量的研究研究了乳腺癌和卵巢癌中的心理肌免疫（PNI）关系，但据我们所知，尚无研究检查子宫内膜癌的这些关系。此外，很少有研究检查接受手术的癌症患者的PNI关系 - 这一时期以高心理和身体压力以及高度易受转移的脆弱性。我们的远程目标是改善子宫内膜癌女性的健康和健康。该应用的目的是评估生命压力，昼夜唾液皮质醇节奏（预测癌症患者的疾病严重程度和死亡率的预测因子），血管内皮生长因子（VEGF）（VEGF）（VEGF）（VEGF）（促进肿瘤血管生成的最有效生长因子（促进肿瘤血管生成的最有效的生长因子，促进肿瘤血管生成，这是新血管与癌症供应肿瘤和牛皮物中的新血管中的过程。该应用的核心假设是，围手术期间的高生命压力将与更异常的皮质醇节奏和更高的VEGF水平有关，并且关系健康/社会支持将缓解这些关系。该中心假设将通过在新诊断的子宫内膜癌症患者的样本中追求以下特定目的进行检验，并接受手术去除子宫，卵巢和输卵管：（目标1）确定生命压力，关系健康健康和唾液性皮质溶质和（目标2）的关系之间的关系，以识别生活压力之间的关系2）。如果我们的假设关系出现，它将指导未来的研究，以研究这些关系预测子宫内膜癌的临床结果和死亡率的程度。由于我们在生物行为和免疫病理学研究方面的综合经验，我们的多学科研究小组在从事拟议的工作方面特别准备工作。拟议的研究具有创新性，因为它将是最早检查接受癌症手术的妇女生物行为关系的人之一。最后，这些结果对公共卫生倡议将是重要的，因为尽管子宫内膜癌是女性中癌症与癌症相关死亡的第四个最常见的癌症，但研究研究了这种疾病的潜在生物行为机制。

项目成果

Life stress, negative mood states, and antibodies to heat shock protein 70 in endometrial cancer.

• DOI: 10.1016/j.bbi.2009.08.008
• 发表时间: 2010-02
• 期刊: BRAIN BEHAVIOR AND IMMUNITY
• 影响因子: 15.1
• 作者: Pereira, Deidre B.;Sannes, Timothy;Dodd, Stacy M.;Jensen, Sally E.;Morgan, Linda S.;Chan, Edward K. L.
• 通讯作者: Chan, Edward K. L.