Lymphoma in Autoimmune Disease: Consequence of Immune Suppression or Stimulation?

自身免疫性疾病中的淋巴瘤：免疫抑制或刺激的后果？

• 批准号: 7264430
• 负责人: Sasha Ruth Bernatsky
• 金额: $ 5.4万
• 依托单位: MCGILL UNIVERSITY HEALTH CTR RES INST
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7264430
• 关键词: Alabama; Antigens; Antineoplastic Agents; Appendix; Attention; Autoimmune Diseases; Autoimmune Process; B Cell Proliferation; Baltimore; Be++ element; Beryllium; California; Cancer Etiology; Chicago; Chronic; Cities; Clinical; Cohort Analysis; Cohort Studies; Data; Development; Disease; Dose; Drug Exposure; Employee Strikes; Environmental Risk Factor; Epidemic; Epidemiologist; Etiology; Evaluation; Functional disorder; Funding; General Population; Genetic; Genetic Risk; Grant; Histology; Illinois; Immune; Immune system; Immunosuppressive Agents; Incidence; International; Knowledge; Learning; Life; Los Angeles; Lupus; Lupus Erythematosus; Lymphocyte; Lymphoma; Maintenance Therapy; Malignant - descriptor; Malignant Neoplasms; Manuscripts; Maryland; Measures; Morbidity - disease rate; New York; Non-Hodgkin' s Lymphoma; North America; North Carolina; Oklahoma; Organ Transplantation; Outcome; Patients; Pennsylvania; Pharmaceutical Preparations; Population; Prevalence; Process; Publishing; Reporting; Research; Research Personnel; Rheumatoid Arthritis; Risk; Role; Source; Staging; Systemic Lupus Erythematosus; United States National Institutes of Health; Virus Diseases; Woman; Work; base; cancer epidemiology; cancer risk; case control; cohort; experience; improved; innovation; insight; interest; lymphocyte proliferation; novel; novel strategies; programs; young adult

DESCRIPTION (provided by applicant): Our research has shown that systemic lupus erythematosus (SLE), one of the most common autoimmune diseases in women, is associated with cancer. By collaborating with researchers worldwide, we have assembled the largest-ever cohort of SLE patients and reported that these patients have an almost 4-fold increased risk of developing lymphoma. However, the reasons for this are not known; the association may be due to the immune system over-activity of SLE itself, the medications used in its treatment, genetic/ environmental factors, or viral infections. Our current application defines an innovative research plan to assess the effect of SLE disease activity on lymphoma development, through a review of lymphoma cases arising in SLE patients. First, we will enlarge our previous cohort so that more cases of lymphoma can be identified. Then, for each lymphoma case identified in our international SLE cohort, controls without cancer will be selected from the cohort. Lupus disease activity will then be compared between cases and controls to determine if patients with higher disease activity are more likely to develop lymphoma. Additionally, by comparing the clinical and pathological features of these lymphomas developing in SLE to those in the general population, we will learn more about the role of SLE activity in increasing cancer risk. Our proposed project will help identify patients at highest risk for lymphoma and provide guidance regarding initiation and maintenance of therapy to control SLE.

描述（由申请人提供）： 我们的研究表明，全身性红斑狼疮（SLE）是女性最常见的自身免疫性疾病之一，与癌症有关。通过与全球研究人员合作，我们组装了有史以来最大的SLE患者队列，并报告说这些患者患淋巴瘤的风险将近4倍。但是，原因尚不清楚。该关联可能是由于SLE本身的免疫系统过度活跃，治疗中使用的药物，遗传/环境因素或病毒感染。我们当前的应用定义了一项创新的研究计划，以评估SLE患者引起的淋巴瘤病例，以评估SLE疾病活动对淋巴瘤发育的影响。首先，我们将扩大以前的队列，以便可以鉴定出更多的淋巴瘤病例。然后，对于在我们的国际SLE队列中确定的每种淋巴瘤病例，将从队列中选择没有癌症的对照。然后，将在病例和对照组之间比较狼疮疾病活性，以确定疾病活性较高的患者是否更有可能发展淋巴瘤。此外，通过将SLE中这些淋巴瘤发展的这些淋巴瘤的临床和病理特征与普通人群中的人进行比较，我们将更多地了解SLE活动在增加癌症风险中的作用。我们拟议的项目将有助于确定淋巴瘤风险最高的患者，并提供有关启动和维持治疗以控制SLE的指导。