ANTI-HIV ACTIVITY OF P GINGIVALIS

牙龈卟啉单胞菌的抗HIV活性

• 批准号: 7380795
• 负责人: HUA XIE
• 金额: $ 35.09万
• 依托单位: MEHARRY MEDICAL COLLEGE
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7380795
• 关键词: ANTI; HIV; ACTIVITY; GINGIVALIS

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The human immunodeficiency virus (HIV) is transmitted to over 16,000 people each day worldwide. Our ongoing studies indicate P. gingivalis can inhibit HIV entry. The purpose of this study is to elucidate the mechanism by which the P. gingivalis component blocks the course of HIV infection. The specific effort of this proposal is to purify and characterize the inhibitory component of P. gingivalis, which may be capable of interfering with the oral transmission of HIV. Our initial investigation is aimed at determination of the prevalence and the anti-HIV activity of P. gingivalis strains isolated from periodontitis sites in HIV seropositive and HIV seronegative individuals, examination of correlation of viral loads and 17-kDa anti-HIV protein, and investigation of the effect of co-infection of HIV-1 and P. gingivalis on the pathogenicities of the organisms. The knowledge gained from this study is expected to increase our understanding of the rarity of HIV oral transmission and to provide new insights into the viral entry process. Furthermore, the study of the P. gingivalis inhibitory component might lead to the discovery of an additional target to complement current anti-HIV drugs.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。人类免疫缺陷病毒 (HIV) 每天传播给全世界超过 16,000 人。我们正在进行的研究表明牙龈卟啉单胞菌可以抑制艾滋病毒的进入。本研究的目的是阐明牙龈卟啉单胞菌成分阻止艾滋病毒感染过程的机制。该提案的具体工作是纯化和表征牙龈卟啉单胞菌的抑制成分，该成分可能能够干扰艾滋病毒的口腔传播。我们的初步调查旨在确定从 HIV 血清阳性和 HIV 血清阴性个体牙周炎部位分离的牙龈卟啉单胞菌菌株的流行率和抗 HIV 活性，检查病毒载量和 17-kDa 抗 HIV 蛋白的相关性，并进行调查HIV-1 和牙龈卟啉单胞菌共同感染对生物体致病性的影响。从这项研究中获得的知识预计将增加我们对艾滋病毒口腔传播罕见性的了解，并为病毒进入过程提供新的见解。此外，对牙龈卟啉单胞菌抑制成分的研究可能会发现一个额外的靶点来补充现有的抗艾滋病毒药物。