Clinical and Basic Neurobiology Nervous System Diseases

临床和基础神经生物学神经系统疾病

• 批准号: 7191850
• 负责人: GEORGE R HENINGER
• 金额: $ 8.08万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-09-25 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7191850
• 关键词: Internet; child psychology; computer assisted instruction; curriculum; education evaluation /planning; educational resource design /development; interactive multimedia; interdisciplinary collaboration; nervous system disorder; neurobiology; neurology; neurosciences; postgraduate education; psychiatry; training; university

DESCRIPTION (provided by applicant): The immense burden of disability and suffering produced by nervous system diseases can best be reduced by educating and involving basic neuroscientists in disease oriented research. To accomplish this we plan to develop a course on the "Clinical and Basic Neurobiology of Diseases of the Nervous System" for all neuroscience graduate students at Yale University and make it available to other neuroscience training programs across the country. The course will be part of the NIH supported "Interdepartmental Neuroscience Program" (INP) (5T32 NS 41228, H. Keshishian PI). The new course will more than double the current 20 lecture course "Cellular and Molecular Mechanisms of Neurologic Disease", which focuses on neurodegenerative diseases. The 2 courses will include a total of 44 lectures covering a wide range of diseases and disorders from the fields of Neurology, Psychiatry and Child Psychiatry. In addition to lectures and a written syllabus, tutorials will be created for each of the 44 lectures utilizing text, graphics, figures, animations and video clips in a web based interactive format to engage students in answering questions and interacting with figures or animations that generate immediate feedback and provide a total score indicating the level of mastery. Each lecture-syllabus-tutorial will include a description of the disease, epidemiology, genetics, case presentations, clinical course, diagnostic methods, treatment, animal models of disease (with a focus on both specific and common neurobiologic mechanisms of pathogenesis), and a discussion of social and ethical aspects of translational research. The course will be directed by an executive-advisory committee led by the 2 co-principle investigators - (a clinician scientist and the principal investigator of the INP) with 3 other members from the Departments of Neurology, Psychiatry and Child Psychiatry and teaching faculty will come from these same 3 organizations. The course will be evaluated with a variety of subjective and objective measures including student scores on the tutorials. The course will have an impact outside Yale University since a webcast of the lecture, the syllabus, and the tutorials will be made available via the internet to other Neuroscience Training Programs. Relevance: The education of basic neuroscience graduate students in the neurobiology of diseases of the nervous system will foster their involvement in disease-oriented research and lead to improved prevention and treatment.

描述（由申请人提供）：通过教育和让基础神经科学家参与面向疾病的研究，可以最好地减轻神经系统疾病造成的残疾和痛苦的巨大负担。为了实现这一目标，我们计划为耶鲁大学所有神经科学研究生开发一门“神经系统疾病的临床和基础神经生物学”课程，并将其提供给全国其他神经科学培训项目。该课程将是 NIH 支持的“跨部门神经科学计划”(INP) 的一部分（5T32 NS 41228，H. Keshishian PI）。新课程将是目前20讲课程“神经系统疾病的细胞和分子机制”的两倍多，该课程专注于神经退行性疾病。这两门课程将包括总共 44 个讲座，涵盖神经病学、精神病学和儿童精神病学领域的广泛疾病和病症。除了讲座和书面教学大纲之外，还将为 44 个讲座中的每一个讲座创建教程，以基于网络的交互格式利用文本、图形、图形、动画和视频剪辑，让学生回答问题并与生成的图形或动画进行交互。立即反馈并提供表明掌握程度的总分。每个讲座-教学大纲-教程将包括疾病的描述、流行病学、遗传学、病例介绍、临床过程、诊断方法、治疗、疾病动物模型（重点关注发病机制的特定和常见神经生物学机制）以及讨论转化研究的社会和伦理方面。该课程将由执行咨询委员会指导，该委员会由 2 名联合首席研究员（一名临床科学家和 INP 的首席研究员）以及来自神经病学、精神病学和儿童科的其他 3 名成员领导 精神病学和教学人员将来自这三个组织。该课程将通过各种主观和客观衡量标准进行评估，包括学生在教程上的成绩。该课程将在耶鲁大学之外产生影响，因为讲座、教学大纲和教程的网络广播将通过互联网向其他神经科学培训项目提供。相关性：对基础神经科学研究生进行神经系统疾病神经生物学教育将促进他们参与以疾病为导向的研究，并改善预防和治疗。