A Novel Treatment to Boost Quit Attempts and Cessation Among Unmotivated Smokers

一种促进无动机吸烟者戒烟尝试和戒烟的新疗法

基本信息

批准号：
7496505
负责人：
Matthew J Carpenter
金额：
$ 30.04万
依托单位：
MEDICAL UNIVERSITY OF SOUTH CAROLINA
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-30 至 2011-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7496505
关键词：
Abstinence Adverse event American Attitude Behavior Belief Cigarette Clinical Cognitive Condition Digit structure Distress Future Goals Hand Incidence Individual Instruction Intervention Life Mails Mediating Mediator of activation protein Methods Minority Numbers Outcome Pharmacologic Substance Policies Population Prevalence Probability Purpose Randomized Clinical Trials Randomized Controlled Clinical Trials Recommendation Recruitment Activity Research Personnel Resistance Safety Sampling Self Efficacy Smoke Smoker Smoking Smoking Cessation Intervention Social support Standards of Weights and Measures Telephone Testing Thinking Time Treatment Efficacy Withdrawal Withdrawal Symptom base behavior test craving day direct to consumer advertising follow-up interest motivational intervention nicotine replacement novel programs self help smoking cessation smoking restriction success

项目摘要

DESCRIPTION (provided by applicant): Increasing smoking cessation can be accomplished not only by increasing the success of a given quit attempt but also by increasing the probability of making a quit attempt. Although policy interventions increase quit attempts, the few treatments for clinicians to motivate individual smokers to make a quit attempt have either small or inconsistent effects. This is especially problematic given the incidence of quit attempts among smokers over the past decade is not increasing. One widely used method to prompt serious quit attempts is to encourage practice-quit attempts as is done by the Great American Smoke out (GAS) and World No Smoking Day (WNSD). We hypothesize providing nicotine replacement therapy (NRT) to use in a practice-quit attempt will make the attempt more successful and less uncomfortable and thus increase the probability of later purposeful attempts to quit smoking permanently. A prior study of ours and other studies have shown that providing NRT to reduce cigarettes per day in smokers not motivated to quit increases their future quit attempts, but no one has tested whether using NRT to aid practice quit attempts also does so. We believe providing NRT will reduce distress during abstinence, produce more favorable attitudes to using NRT and increase self-efficacy for quitting. Interestingly, others have hypothesized the opposite; i.e. that the provision of NRT for goals other than life-long abstinence will decrease rather than increase future quit attempts. We propose a randomized clinical trial of a) brief advice to undertake a = 24 hr practice quit attempt or b) brief advice plus free NRT. Trial methods will be very similar to our prior study. A population-based sample of 744 unmotivated smokers will be recruited via random-digit dialing and a behavioral test to include only those with no current plans to quit. All treatments and assessments will be delivered via telephone and mailings. Though our study will assess a number of quit attempt definitions, our primary outcome is the incidence of a serious attempt to permanently stop smoking made over a six-month study period. We will also assess point prevalent abstinence as a secondary outcome and will test our hypothesized mediators of any NRT effects. If successful, this study will 1) offer a new treatment option for clinicians to motivate smokers to try to quit, 2) test whether the hypothesis that using NRT for non-abstinence outcomes undermines abstinence is correct, and 3) suggest tests of relabeling over-the-counter NRT to include use for non-cessation purposes such as practice quit attempts and tests of providing NRT samples to individuals.

描述（由申请人提供）：不仅可以通过增加给定退出尝试的成功，还可以增加进行戒烟尝试的可能性来实现增加的戒烟。尽管政策干预措施增加了戒烟的尝试，但临床医生激励单个吸烟者进行戒烟尝试的少数治疗方法具有很小或不一致的影响。考虑到过去十年中吸烟者的戒烟尝试的发生率并没有增加，这尤其有问题。一种广泛的方法来引发严重戒烟的尝试是鼓励练习试图，就像大美国烟雾（GAS）和世界无吸烟日（WNSD）所做的那样。我们假设提供尼古丁替代疗法（NRT）在练习期间使用将使尝试更加成功和不舒服，从而增加了以后有目的的尝试永久性戒烟的可能性。先前对我们和其他研究的研究表明，在没有动力戒烟的吸烟者中提供NRT减少每天的香烟会增加未来的戒烟尝试，但是没有人测试是否使用NRT来帮助练习练习戒烟尝试也是如此。我们认为，提供NRT会减少戒酒期间的困扰，对使用NRT产生更有利的态度，并提高自我效能的戒烟。有趣的是，其他人假设相反。即，除了终身禁欲以外的其他目标，NRT为目标提供了减少，而不是增加未来的戒烟尝试。我们提出了一项随机临床试验a）简短建议a = 24小时练习戒烟尝试或b）简短的建议和免费的NRT。试验方法将与我们先前的研究非常相似。将通过随机数字拨号招募744名未充满动力的吸烟者的样本，并进行行为测试，仅包括那些没有当前戒烟计划的人。所有处理和评估将通过电话和邮件进行。尽管我们的研究将评估许多戒烟的定义，但我们的主要结果是认真尝试在六个月的研究期间永久性吸烟的发生率。我们还将评估普遍的禁欲作为次要结果，并将测试我们假设的NRT效应的介体。 If successful, this study will 1) offer a new treatment option for clinicians to motivate smokers to try to quit, 2) test whether the hypothesis that using NRT for non-abstinence outcomes undermines abstinence is correct, and 3) suggest tests of relabeling over-the-counter NRT to include use for non-cessation purposes such as practice quit attempts and tests of providing NRT samples to individuals.