Ecologic Stressors, PTSD, and Drug Use in Detroit

底特律的生态压力源、创伤后应激障碍和药物滥用

基本信息

批准号：
7315043
负责人：
SANDRO MD, MPH, DRPH GALEA
金额：
$ 63.02万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-09-15 至 2012-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7315043
关键词：
Accounting Alcohol dependence Area Behavior Behavioral Biological Classification Cocaine Cytomegalovirus Data Dependence Disadvantaged Discrimination Disease Drug Addiction Drug Use Disorder Drug abuse Drug usage Environment Epidemiologic Studies Ethnic Origin Etiology Event Exposure to Fingers Gender Goals Health Health Surveys Heroin Human Herpesvirus 4 Immune Immune System Diseases Immune response Incidence Income Distributions Individual Inflammatory Inflammatory Response Interview Link Measures Mediating Mental Health Methods Morbidity - disease rate Neighborhoods Paper Participant Pathology Pathway interactions Persons Pharmaceutical Preparations Population Post-Traumatic Stress Disorders Probability Samples Proteins Psyche structure Psychoneuroimmunology Psychopathology Psychosocial Stress Purpose Race Reaction Recruitment Activity Research Personnel Respondent Risk Sampling Shapes Source Staging Stress Surveys Symptoms Time Urban Health Work behavioral health cohort design immune function interest multilevel analysis programs residence response segregation stressor

项目摘要

DESCRIPTION (provided by applicant): Emerging evidence suggests that stressors at multiple levels are important predictors of psychopathology and behavior. Post-traumatic stress disorder (PTSD) and drug abuse/dependence are among the most prevalent and disabling behavioral pathologies. The purpose of this project is to determine whether ecologic stressors (concentrated disadvantage, income distribution, residential segregation, quality of the built environment), influence the risk of post-traumatic stress disorder (PTSD), and drug abuse/dependence among residents of Detroit. Additionally, we will begin to study the pathways linking ecologic stressors to long-term health through assessing the interrelationship among ecologic stressors, exposure to potentially traumatic events (PTEs), PTSD, drug abuse/dependence, and immune and inflammatory function. Our central hypothesis is that exposure to ecologic stressors is a fundamental determinant of population mental and behavioral health and that, particularly in the urban context, ecologic factors influence (a) the risk of PTE exposure, (b) the risk of PTSD given exposure to a PTE, (c) the risk of drug abuse/dependence, (d) the interrelationship between PTSD and drug abuse/dependence, and (e) some of the consequences of psychopathology. Although recent work has shown that stressors at multiple levels may be important determinants of psychopathology there has been very little systematic effort to understand the contributions of ecologic stressors to the risk of incident PTSD or drug abuse/dependence while also accounting for individual stressors. This project then aims to disentangle the contribution of stressors at multiple levels to the etiology of PTSD and drug abuse/dependence and how these stressors shape the relationship between these pathologies. Secondarily, we propose to consider the consequences of PTSD in the context of ecologic stressors, particularly the relation between PTSD and immune and inflammatory function, and how these consequences are shaped by exposure to ecologic stressors. Multilevel modeling principally will be used to evaluate whether ecologic stressors are associated with PTSD and drug abuse/dependence and to assess the relation among ecologic stressors, PTSD, immune functioning, and inflammatory measures.

描述（由申请人提供）：新兴证据表明，多个级别的压力源是心理病理学和行为的重要预测指标。创伤后应激障碍（PTSD）和药物滥用/依赖性是最普遍，最残疾的行为病理之一。该项目的目的是确定生态压力源（集中劣势，收入分配，住宅隔离，建筑环境的质量）是否会影响底特律居民的创伤后应激障碍（PTSD）（PTSD）（PTSD）的风险以及药物滥用/依赖性。此外，我们将通过评估生态压力源之间的相互关系，潜在的创伤事件（PTES），PTSD，药物滥用/依赖性以及免疫和炎症功能来研究将生态压力与长期健康联系起来的途径。我们的核心假设是，暴露于生态压力源是人口心理和行为健康的基本决定因素，尤其是在城市环境中，生态因素会影响（a）PTE暴露的风险，（a）PTSD暴露于PTE的风险，PTE暴露于PTE，PTE，（c）药物滥用/依赖性的某些相互依赖的风险，（d）（d）（d）（d）（d）（d）（d）（d）（D）心理病理学。尽管最近的工作表明，在多个层面上的压力源可能是心理病理学的重要决定因素，但很少有系统的努力来理解生态压力源对事件发生PTSD或药物滥用/依赖性风险的贡献，同时还可以考虑个体压力。然后，该项目旨在解散压力源在多个级别对PTSD和药物滥用/依赖性病因的贡献，以及这些压力源如何塑造这些病理之间的关系。其次，我们建议在生态压力源，尤其是PTSD与免疫和炎症功能之间的关系以及如何通过暴露于生态压力源来影响这些后果的情况下考虑PTSD的后果。多级建模主要用于评估生态压力源是否与PTSD和药物滥用/依赖性相关，并评估生态压力源，PTSD，免疫功能和炎症措施之间的关系。